Results 11 to 20 of about 14,616 (219)

Transcriptome and Metabolome Analyses Reveal Complex Molecular Mechanisms Involved in the Salt Tolerance of Rice Induced by Exogenous Allantoin

Antioxidants, 2022
Allantoin is crucial for plant growth and development as well as adaptations to abiotic stresses, but the underlying molecular mechanisms remain unclear.
Juan Wang, Yingbo Li, Yinxiao Wang, Fengping Du, Yue Zhang, Ming Yin, Xiuqin Zhao, Jianlong Xu, Yongqing Yang, Wensheng Wang, Binying Fu   +10 more
doaj   +1 more source

Assessment of allantoin concentrations in comfrey root available on the Polish market

Acta Agrobotanica, 2023
Comfrey ( Symphytum officinale L.) root is a commonly known rich source of allantoin. This compound is widely used in pharmacy and cosmetology, but mainly in a synthetic form. However, the properties of natural allantoin in products of biological origin
Barbara Hawrylak-Nowak, Sławomir Dresler   +1 more
doaj   +1 more source

E. coli allantoinase is activated by the downstream metabolic enzyme, glycerate kinase, and stabilizes the putative allantoin transporter by direct binding

Scientific Reports, 2023
Allantoin is a good source of ammonium for many organisms, and in Escherichia coli it is utilized under anaerobic conditions. We provide evidence that allantoinase (AllB) is allosterically activated by direct binding of the allantoin catabolic enzyme ...
Irina A. Rodionova, Ali Hosseinnia, Sunyoung Kim, Norman Goodacre, Li Zhang, Zhongge Zhang, Bernhard Palsson, Peter Uetz, Mohan Babu, Milton H. Saier   +9 more
doaj   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Serum but not cerebrospinal fluid levels of allantoin are increased in de novo Parkinson’s disease

npj Parkinson's Disease, 2023
Oxidative stress supposedly plays a role in the pathogenesis of Parkinson’s disease (PD). Uric acid (UA), a powerful antioxidant, is lowered in PD while allantoin, the oxidation product of UA and known biomarker of oxidative stress, was not ...
Lenka Hasíková, Jakub Závada, Tereza Serranová, Petr Kozlík, Květa Kalíková, Lenka Kotačková, Jiří Trnka, David Zogala, Karel Šonka, Evžen Růžička, Petr Dušek   +10 more
doaj   +1 more source

Exogenous Allantoin Confers Rapeseed (Brassica campestris) Tolerance to Simulated Drought by Improving Antioxidant Metabolism and Physiology

Antioxidants, 2023
Allantoin is an emerging plant metabolite, but its role in conferring drought-induced oxidative stress is still elusive. Therefore, an experiment was devised to explore the role of allantoin (0.5 and 1.0 mM; foliar spray) in rapeseed (Brassica campestris
Md. Rakib Hossain Raihan, Mira Rahman, Anshu Rastogi, Masayuki Fujita, Mirza Hasanuzzaman   +4 more
doaj   +1 more source

Allantoin ameliorates chemically-induced pancreatic β-cell damage through activation of the imidazoline I3 receptors [PDF]

PeerJ, 2015
Objective. Allantoin is the primary active compound in yams (Dioscorea spp.). Recently, allantoin has been demonstrated to activate imidazoline 3 (I3) receptors located in pancreatic tissues.
Marie Amitani, Kai-Chun Cheng, Akihiro Asakawa, Haruka Amitani, Timothy Sean Kairupan, Nanami Sameshima, Toshiaki Shimizu, Teruto Hashiguchi, Akio Inui   +8 more
doaj   +2 more sources

Allantoin improves methionine-choline deficient diet-induced nonalcoholic steatohepatitis in mice through involvement in endoplasmic reticulum stress and hepatocytes apoptosis-related genes expressions [PDF]

Iranian Journal of Basic Medical Sciences, 2019
Objective(s): Non-alcoholic steatohepatitis (NASH) is defined by steatosis and inflammation in the hepatocytes, which can progress to cirrhosis and possibly hepatocellular carcinoma. However, current treatments are not entirely effective.
Tahereh Komeili Movahhed, Azam Moslehi, Mohammad Golchoob, shima ababzadeh   +3 more
doaj   +1 more source

Attenuating effects of allantoin on oxidative stress in a mouse model of nonalcoholic steatohepatitis: role of SIRT1/Nrf2 pathway

Research in Pharmaceutical Sciences, 2021
Background and purpose: Nonalcoholic steatohepatitis (NASH) is considered a common and serious liver disease, which develops into cirrhosis, fibrosis, and even hepatocellular carcinoma.
Zeinab Hamidi-zad, Azam Moslehi, Maryam Rastegarpanah   +2 more
doaj   +1 more source

Uric acid enhances longevity and endurance and protects the brain against ischemia [PDF]

, 2020
Among mammals, there is a positive correlation between serum uric acid (UA) levels and life span. Humans have high levels of UA because they lack a functional urate oxidase (UOX) enzyme that is present in shorter lived mammals.
Argüelles Castilla, Sandro, Camandola, Simonetta, Cutler, Roy G., Feldman, Neil H., Haran, James B., Mattsona, Mark P., Seon Yoon, Jeong   +6 more
core   +1 more source