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Conventional tests, such as specific IgE (sIgE) or intradermal testing (IDT), are usually sufficient. Combining both tests increases sensitivity, while additional tests, like the basophil activation test (BAT), provide no further benefit for the majority of patients.
Lisa Arzt‐Gradwohl +8 more
wiley +1 more source
Sublingual immunotherapy for the treatment of allergies
The treatment of allergies often involves pharmacological therapy and recommendations by healthcare workers that the allergen should be avoided. Allergen-specific immunotherapy has emerged as an alternative to effectively decrease the immunoglobulin (Ig)
Natalie Schellack, D. Engler
doaj +1 more source
Improved diagnosis and vaccination of pet allergy : from molecular mechanisms to clinic [PDF]
Allergy is a disease affecting around 30% of the population worldwide, causing extensive suffering for individual patients and constituting a significant socioeconomic burden to society.
Binnmyr, Jonas
core +1 more source
Oral Immunotherapy Induces Shift in lncRNA Expression Modulating Allergen‐Specific Immune Responses
We used PBMC transcriptome from 50 hen's egg‐allergic patients to study the role of lncRNA in OIT. Positive correlation was found between 17 lncRNAs and the IL‐4/IL‐13 pathway in vivo, and the expression of the selected lncRNA aligned with CXCL8 upon PBMC egg‐restimulation.
Olivia Liong +5 more
wiley +1 more source
Immunotherapy for pet allergies
Allergic diseases compose a serious challenge for modern societies. Their individual, medical and economical burden is large. As humans spend most of their time indoors, exposure to indoor allergens is a significant contributor to the development of ...
Tuomas Virtanen
doaj +1 more source
Biomarkers for Allergen Immunotherapy in Cedar Pollinosis
To initiate, monitor, and complete effective immunotherapy, biomarkers to predict and visualize the immune responses are needed. First, we need to identify the right candidate for immunotherapy.
Takao Fujisawa +9 more
doaj +1 more source
Depigmented-polymerised allergoids favour regulatory over effector T cells: enhancement by 1α, 25-dihydroxyvitamin D3 [PDF]
Background: Allergen immunotherapy (SIT) is the only treatment for allergic disease capable of modifying disease long term. To reduce the risk of anaphylaxis from SIT, allergen-extracts have been modified by polymerisation with glutaraldehyde to reduce ...
Catherine M Hawrylowicz +6 more
core +2 more sources
The RHAPSODY multinational study investigated 26 months of continuous treatment with 5‐grass‐pollen sublingual SLIT drops in adults with moderate‐to‐severe grass‐pollen‐induced allergic rhinoconjunctivitis. The primary efficacy endpoint (the average daily total combined score) showed statistically significant differences in favour of the active ...
Alain Didier +4 more
wiley +1 more source
FAST: Towards safe and effective subcutaneous immunotherapy of persistent life-threatening food allergies. [PDF]
To access publisher's full text version of this article. Please click on the hyperlink in Additional Links field.ABSTRACT: The FAST project (Food Allergy Specific Immunotherapy) aims at the development of safe and effective treatment of food allergies ...
A Bonura +41 more
core +3 more sources
Sequence of Immunological Events During IgE‐Mediated Allergic Reactions to Food
ABSTRACT Food allergies (FA) represent a significant global health burden. Upon allergen re‐exposure, allergic patients exhibit a sequence of symptoms that vary in terms of affected organ systems, severity, time of onset and allergen reactivity thresholds.
N. A. Nagy +7 more
wiley +1 more source

