Results 111 to 120 of about 936,865 (297)

Mer-mediated eosinophil efferocytosis regulates resolution of allergic airway inflammation [PDF]

, 2018
Background: Eosinophils play a central role in the propagation of allergic diseases including asthma. Both recruitment and retention of eosinophils regulate pulmonary eosinophilia but the question of whether alterations in apoptotic cell clearance by ...
Christopher D. Lucas, Bryan Serrels, Jürgen Schwarze, Tiina Kipari, Rodger Duffin, Christopher Haslett, Vermeren, Sonja; id_orcid, Serrels, Bryan, Lucas, Christopher D.; id_orcid, Robb, Calum, David A. Dorward, Kenneth G. MacLeod, Felton, Jennifer, Sonja Vermeren, Calum T. Robb, Rossi, Adriano G., Dransfield, Ian, Adriano G. Rossi, Kipari, Tiina, Duffin, Rodger, Ian Dransfield, Macleod, Kenneth, Schwarze, Jürgen, Haslett, Christopher, Dorward, David A., Jennifer M. Felton   +25 more
core   +1 more source

Plasma Proteome Reflects Tissue Damage and Clinical Manifestations in Patients With Inflammatory Myopathies

Arthritis &Rheumatology, EarlyView.
Objective Tissue‐specific biomarkers that are reliable and associated with clinical manifestations of idiopathic inflammatory myopathy (IIM) are lacking. The blood circulation in individuals serves as a central conduit, allowing communication between tissues and facilitating clearance and recycling of tissue‐derived proteins.
Yue‐Bei Luo, Josefin Kenrick, Angeles S. Galindo‐Feria, Antonella Notarnicola, Ana Daniela Ulloa Navas, Irene Peralta‐Garcia, Orane Demuynck, Andrea Kemp, Valérie Leclair, Karin Lodin, Eveline Van Gompel, Lara Dani, Fabricio Espinosa‐Ortega, Maryam Dastmalchi, Leonid Padyukov, Charlotta Preger, María Bueno Álvez, Mathias Uhlén, Peter Nilsson, Fredrik Edfors, Lina‐Marcela Diaz‐Gallo, Elisa Pin, Ingrid E. Lundberg, Begum Horuluoglu   +23 more
wiley   +1 more source

Experimental Model of Pulmonary Allergic Inflammation Induced by Latex in Balb/c [PDF]

Cell Journal, 2005
Introduction: The prevalence of allergic airway diseases has dramatically increased in recent years all over the world. Murine models of allergic airway inflammation have provided helpful information about treatment and cellular and molecular mechanisms ...
Parvaneh Farzaneh, Zuhair Mohammad Hassan, Zahra Pourpak, Ahmad Zavaran Hoseini, Ahmad Reza Baghestani, Simon Hogan   +5 more
doaj  

Pharmacokinetics and safety of tezepelumab in children with mild, moderate or severe asthma and adolescents with mild‐to‐moderate asthma

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Tezepelumab is a human monoclonal antibody that blocks the activity of thymic stromal lymphopoietin and is approved for adolescents and adults with severe asthma. This analysis assessed pharmacokinetics (PK), pharmacodynamics and safety of tezepelumab up to 85 days postdose in adolescents and children.
Anna Lundahl, Jonathan Grigg, Lubna Abuqayyas, Piotr Kuna, Gillian Hunter, Beata Pawlikowska, Jacob Leander, Michael Levin, Atul Gupta, James Paton, Katharine C. Pike, Jane R. Parnes, Gun Almqvist, Stephanie L. Roseti, on behalf of the study investigators   +14 more
wiley   +1 more source

Impact of Chronic Allergic Inflammation on de novo Sensitization and Airway Remodeling in a Mouse Model of Allergic Airway Disease [PDF]

, 2009
Allergic asthma is a chronic inflammatory disease of the airways. Importantly, the chronic nature of this disease imparts specific additional consequences that would not otherwise be observed in a strictly acute setting.
Fattouh, Ramzi
core  

Characterizing the Epithelial Transcriptome of Type‐2 High Chronic Rhinosinusitis

International Forum of Allergy &Rhinology, EarlyView.
Brian Cameron, Jeffanie Gayoso, Christina Dorismond, Ping Li, Mason Krysinski, Rakesh Chandra, Justin Turner, Naweed Chowdhury   +7 more
wiley   +1 more source

Twenty years of inhaler therapy: A nationwide drug utilization study

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to map nationwide trends and prescribing patterns in inhaler use from 2004 to 2023. In light of evolving clinical guidelines and attention to the environmental impact of inhalers within recent years, we also examined variation in prescribing behaviour and patient‐level treatment choices. Methods Using nationwide health registries,
Katrine Bitsch Johansen, Lars Christian Lund, Zandra Nymand Ennis, Andrew Scourfield, Anders Løkke, Sidsel Arnspang Pedersen   +5 more
wiley   +1 more source

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Anti-inflammatory Property of Galectin-1 in a Murine Model of Allergic Airway Inflammation

Journal of Immunology Research, 2019
Galectin-1 (Gal-1) has immunomodulatory activities in various allergic inflammatory disorders, but its potential anti-inflammatory properties on allergic airway diseases have not been confirmed.
Yunxiang Lv, Mengyuan Dai, Muzi Wang, Fangfang Chen, Rongyu Liu   +4 more
doaj   +1 more source

Citrus/Cydonia Comp. Can Restore the Immunological Balance in Seasonal Allergic Rhinitis-Related Immunological Parameters In Vitro [PDF]

, 2008
In two in vitro studies, we examined the immunological (pathways of the) effects of Citrus/Cydonia comp. from, respectively, a healthy and an allergic donor; peripheral blood mononuclear cells (PBMCs) were isolated out of peripheral blood and analyzed in
E. W. Baars, Baars, E.W., Savelkoul, H.F.J., H. F. J. Savelkoul   +3 more
core   +1 more source