Results 11 to 20 of about 255,027 (296)

Preclinical Evaluation of the Safety and Immunological Action of Allogeneic ADSC-Collagen Scaffolds in the Treatment of Chronic Ischemic Cardiomyopathy

Pharmaceutics, 2021
The use of allogeneic adipose-derived mesenchymal stromal cells (alloADSCs) represents an attractive approach for treating myocardial infarction (MI).
Ascensión López-Díaz de Cerio, Iñigo Perez-Estenaga, Susana Inoges, Gloria Abizanda, Juan José Gavira, Eduardo Larequi, Enrique Andreu, Saray Rodriguez, Ana Gloria Gil, Verónica Crisostomo, Francisco Miguel Sanchez-Margallo, Javier Bermejo, Blanca Jauregui, Lluis Quintana, Francisco Fernández-Avilés, Beatriz Pelacho, Felipe Prósper   +16 more
doaj   +1 more source

Successful allogeneic hematopoietic stem cell transplantation in patients with VEXAS syndrome: a 2-center experience

Blood Advances, 2021
Key Points Allogeneic hematopoietic stem cell transplantation is a curative option in patients with VEXAS syndrome and severe manifestations.
Ava Diarra, Nicolas Duployez, E. Fournier, C. Preudhomme, V. Coiteux, L. Magro, B. Quesnel, M. Heiblig, P. Sujobert, F. Barraco, M. Balsat, Quentin Scanvion, E. Hachulla, D. Launay, I. Yakoub-Agha, L. Terriou   +15 more
semanticscholar   +1 more source

Human Vδ2 T Cells and Their Versatility for Immunotherapeutic Approaches

Cells, 2022
Gamma/delta (γδ) T cells are innate-like immune effectors that are a critical component linking innate and adaptive immune responses. They are recognized for their contribution to tumor surveillance and fight against infectious diseases.
Marta Sanz, Brendan T. Mann, Alisha Chitrakar, Natalia Soriano-Sarabia   +3 more
doaj   +1 more source

Allogeneic CAR Cell Therapy—More Than a Pipe Dream

Frontiers in Immunology, 2021
Adoptive cellular immunotherapy using immune cells expressing chimeric antigen receptors (CARs) has shown promise, particularly for the treatment of hematological malignancies.
Kenneth J. Caldwell, S. Gottschalk, Aimee C. Talleur   +2 more
semanticscholar   +1 more source

Donor lymphocyte count and thymic activity predict lymphocyte recovery and outcomes after matched-sibling hematopoietic stem cell transplant

Haematologica, 2013
Delayed immune recovery is a characteristic feature of allogeneic hematopoietic stem cell transplantation in adult recipients. Although recipient thymic T-cell neogenesis contributes to T-cell regeneration after transplantation, thymic recovery in the ...
Zachariah McIver, Jan Joseph Melenhorst, Colin Wu, Andrew Grim, Sawa Ito, Irene Cho, Nancy Hensel, Minoo Battiwalla, Austin John Barrett   +8 more
doaj   +1 more source

HLA Class I Knockout Converts Allogeneic Primary NK Cells Into Suitable Effectors for “Off-the-Shelf” Immunotherapy

Frontiers in Immunology, 2021
Cellular immunotherapy using chimeric antigen receptors (CARs) so far has almost exclusively used autologous peripheral blood-derived T cells as immune effector cells.
Keven Hoerster, Markus Uhrberg, Constanze Wiek, Peter A. Horn, Peter A. Horn, Helmut Hanenberg, Helmut Hanenberg, Stefan Heinrichs, Stefan Heinrichs   +8 more
doaj   +1 more source

Hematopoietic cell transplantation (HCT)-specific comorbidity index: a new tool for risk assessment before allogeneic HCT.

Blood, 2005
We previously reported that the Charlson Comorbidity Index (CCI) was useful for predicting outcomes in patients undergoing allogeneic hematopoietic cell transplantation (HCT). However, the sample size of patients with scores of 1 or more, captured by the
M. Sorror, M. Maris, R. Storb, F. Baron, B. Sandmaier, D. Maloney, B. Storer   +6 more
semanticscholar   +1 more source

A prospective randomized trial comparing cyclosporine/methotrexate and tacrolimus/sirolimus as graft-versus-host disease prophylaxis after allogeneic hematopoietic stem cell transplantation

Haematologica, 2016
Improvement of graft-versus-host disease prophylaxis remains an important goal in allogeneic hematopoietic stem cell transplantation. Based on reports of possibly preferential properties of sirolimus, we compared the standard regimen of cyclosporine and ...
Johan Törlén, Olle Ringdén, Karin Garming-Legert, Per Ljungman, Jacek Winiarski, Kari Remes, Maija Itälä-Remes, Mats Remberger, Jonas Mattsson   +8 more
doaj   +1 more source

Donor Cell Composition and Reactivity Predict Risk of Acute Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation

Journal of Immunology Research, 2016
Background. Graft-versus-host disease (GVHD) is a serious complication after allogeneic hematopoietic stem cell transplantation (HSCT). We designed a functional assay for assessment of individual risk for acute GVHD. Study Design and Methods.
Darius Sairafi, Arwen Stikvoort, Jens Gertow, Jonas Mattsson, Michael Uhlin   +4 more
doaj   +1 more source

Improved outcomes over time and higher mortality in CMV seropositive allogeneic stem cell transplantation patients with COVID-19; An infectious disease working party study from the European Society for Blood and Marrow Transplantation registry

Frontiers in Immunology, 2023
IntroductionCOVID-19 has been associated with high morbidity and mortality in allogeneic hematopoietic stem cell transplant (allo-HCT) recipients.MethodsThis study reports on 986 patients reported to the EBMT registry during the first 29 months of the ...
Per Ljungman, Per Ljungman, Gloria Tridello, Jose Luis Piñana, Jose Luis Piñana, Fabio Ciceri, Henrik Sengeloev, Alexander Kulagin, Stephan Mielke, Stephan Mielke, Zeynep Arzu Yegin, Matthew Collin, Sigrun Einardottir, Sigrun Einardottir, Sophie Ducastelle Lepretre, Johan Maertens, Antonio Campos, Elisabetta Metafuni, Herbert Pichler, Frantisek Folber, Frantisek Folber, Carlos Solano, Emma Nicholson, Meltem Kurt Yüksel, Kristina Carlson, Beatriz Aguado, Caroline Besley, Jenny Byrne, Immaculada Heras, Fiona Dignan, Nicolaus Kröger, Christine Robin, Anjum Khan, Stig Lenhoff, Anna Grassi, Veronika Dobsinska, Nuno Miranda, Maria-Jose Jimenez, Ipek Yonal-Hindilerden, Keith Wilson, Dina Averbuch, Simone Cesaro, Alienor Xhaard, Nina Knelange, Jan Styczynski, Malgorzata Mikulska, Rafael de la Camara   +46 more
doaj   +1 more source