Results 71 to 80 of about 255,027 (296)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Allogeneic fibroblasts ameliorate intervertebral disc degeneration by reducing osteophytes in rabbits

Frontiers in Medicine
IntroductionLow back pain (LBP) was commonly induced by intervertebral disc degeneration (IVDD), which is accompanied by the loss of disc height and osteophyte generation.
Chen Chen, Yizhuo Huang, Lei Shi, Li Zhou, Shenao Zhou, Shenao Zhou, Hongjin Wan, Xiao Yang, Jie Zhao   +8 more
doaj   +1 more source

In vitro testing of immunosupressive effects of mesenchymal stromal cells on lymphocytes stimulated with alloantigens

Biomedical Papers, 2015
Aims: Mesenchymal stromal cells (MSC) derived from adult bone marrow or adipose tissue offer the potential to open a new frontier in medicine. MSC are involved in modulating immune response and tissue repair in vitro and in vivo.
Daniel Lysak, Tomas Vlas, Monika Holubova, Michaela Miklikova, Pavel Jindra   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Translational Clinical Research: Use of Allogeneic Platelet-Rich Fibrin (PRF) for Wound Regeneration in Two Small-Sized Dogs

Animals
Platelet-rich fibrin (PRF) is a recent regenerative biomaterial applied in clinical wound healing. This study aims to evaluate the safety and efficacy of allogeneic PRF therapy as a regenerative methodology for treating skin wounds in two small dogs.
Carla S. Soares, Isabel R. Dias, Luís C. Barros, Pedro P. Carvalho, Maria dos Anjos Pires   +4 more
doaj   +1 more source

Immune Reconstitution after Allogeneic Hematopoietic Stem Cell Transplantation

Frontiers in Immunology, 2016
The timely reconstitution and regain of function of a donor-derived immune system is of utmost importance for the recovery and long-term survival of patients after allogeneic hematopoietic stem cell transplantation (HSCT).
J. Ogonek, Mateja Kralj Juric, Sakhila Ghimire, P. Varanasi, E. Holler, H. Greinix, E. Weissinger   +6 more
semanticscholar   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Immunoprivileged no more: measuring the immunogenicity of allogeneic adult mesenchymal stem cells

Stem cell research & therapeutics, 2017
BackgroundAutologous and allogeneic adult mesenchymal stem/stromal cells (MSCs) are increasingly being investigated for treating a wide range of clinical diseases. Allogeneic MSCs are especially attractive due to their potential to provide immediate care
A. Berglund, L. Fortier, D. Antczak, L. Schnabel   +3 more
semanticscholar   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

O transplante de células-tronco hematopoéticas como opção no tratamento de doenças não hematológicas Hematopoietic stem cell transplant: a therapeutic option for non-hematologic diseases

Revista Brasileira de Hematologia e Hemoterapia, 2009
Nesta revisão são abordadas as doenças em que existem dados e perspectivas do uso de transplante de células-tronco hematopoéticas em suas diversas modalidades.
Milton A. Ruiz, Lilian Piron-Ruiz, Mario R. Lago, Angelo Maset, Adriana B. Santos, Oswaldo T. Greco   +5 more
doaj   +1 more source