Recurrent myelitis after allogeneic stem cell transplantation. Report of two cases [PDF]
BMC Neurology, 2010 Background Allogeneic and autologous haematopoietic stem cell transplantation are established treatment options for haematological malignancies and may possibly be employed to treat a range of genetic and autoimmune diseases.
Voß Martin, Bischof Felix
doaj +5 more sources
Tyrosine kinase inhibitors improve long-term outcome of allogeneic hematopoietic stem cell transplantation for adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia [PDF]
Haematologica, 2015 This study aimed to determine the impact of tyrosine kinase inhibitors given pre- and post-allogeneic stem cell transplantation on long-term outcome of patients allografted for Philadelphia chromosome-positive acute lymphoblastic leukemia.
Eolia Brissot +20 more
doaj +3 more sources
In Silico Derivation of HLA-Specific Alloreactivity Potential from Whole Exome Sequencing of Stem Cell Transplant Donors and Recipients: Understanding the Quantitative Immuno-biology of Allogeneic Transplantation [PDF]
Frontiers in Immunology 2014. 5:529, 2014 Donor T cell mediated graft vs. host effects may result from the aggregate alloreactivity to minor histocompatibility antigens (mHA) presented by the HLA in each donor-recipient pair (DRP) undergoing stem cell transplantation (SCT). Whole exome sequencing has demonstrated extensive nucleotide sequence variation in HLA-matched DRP. Non-synonymous single
Batalo, Michael +14 more
arxiv +5 more sources
Stem Cell Transplantation As A Dynamical System: Are Clinical Outcomes Deterministic? [PDF]
Frontiers in Immunology (2014). 5:613, 2014 Outcomes in stem cell transplantation (SCT) are modeled using probability theory. However the clinical course following SCT appears to demonstrate many characteristics of dynamical systems, especially when outcomes are considered in the context of immune reconstitution.
Buck, Gregory A +16 more
arxiv +5 more sources
Relapse primary central nervous system lymphoma successfully consolidated with allogeneic stem cell transplantation with thiotepa/busulfan/fludarabine conditioning [PDF]
, 2023 Primary central nervous system lymphoma (PCNSL) is generally characterized by a poor prognosis and frequent relapsing disease. Consolidation therapy in the upfront setting usually consists of an autologous stem cell transplantation. We report the case of
Doorduijn, JK +3 more
core +1 more source
Bone Marrow Transplantation, 2021 Allogeneic hematopoietic stem cell transplantation (alloSCT) carries the promise of cure for many malignant and non-malignant diseases of the lympho-hematopoietic system.
T. Luft, P. Dreger, A. Radujkovic
semanticscholar +1 more source
Allogeneic Stem Cell Transplantation for MDS [PDF]
Hemato, 2021 Myelodysplastic syndromes are clonal disorders with morphological dysplasia, a variable degree of cytopenia and a risk of transformation to acute myeloid leukemia. Prognosis is very variable and is defined by blast count, cytopenia, cytogenetics and more recently by somatic mutations, with IPSS or revised IPSS score being the most widely used to assess
Sara Villar, Marie Robin
openaire +2 more sources
Blood Advances, 2021 Key Points Allogeneic hematopoietic stem cell transplantation is a curative option in patients with VEXAS syndrome and severe manifestations.
Ava Diarra +15 more
semanticscholar +1 more source
Evading the Immune System: Immune Modulation and Immune Matching in Cell Replacement Therapies for Parkinson’s Disease [PDF]
, 2021 Stem cell-based therapies for Parkinson’s disease are now being applied clinically. Notably, studies have shown that controlling the graft-induced immune response improves the results.
Morizane, Asuka, Takahashi, Jun
core +1 more source
T Cell Therapy in Allogeneic Stem Cell Transplantation [PDF]
Biology of Blood and Marrow Transplantation, 2008 T cells derived from healthy stem cell donors can mediate curative immune responses after allogeneic stem cell transplantation (SCT) by eliminating (residual) hematopoietic tumor cells life-threatening viral infections. The first evidence for the crucial role of T cells came from the observations that depletion of T cells from a stem cell graft to ...
A. John Barrett +2 more
openaire +2 more sources