Results 11 to 20 of about 166,368 (358)

Treatment of Adult Patients with Relapsed/Refractory B-Cell Philadelphia-Negative Acute Lymphoblastic Leukemia [PDF]

, 2019
The majority of adult patients affected by B-cell acute lymphoblastic leukemia (B-ALL) will relapse after an initial response, while approximately 20% will display primary resistant disease. Patients suffering from relapsed/refractory B-ALL have a very
Lanza, Francesco, Maffini, Enrico, Saraceni, Francesco   +2 more
core   +1 more source

Donor Cell Composition and Reactivity Predict Risk of Acute Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation

Journal of Immunology Research, 2016
Background. Graft-versus-host disease (GVHD) is a serious complication after allogeneic hematopoietic stem cell transplantation (HSCT). We designed a functional assay for assessment of individual risk for acute GVHD. Study Design and Methods.
Darius Sairafi, Arwen Stikvoort, Jens Gertow, Jonas Mattsson, Michael Uhlin   +4 more
doaj   +1 more source

Respiratory Virus Infections in Hematopoietic Cell Transplant Recipients

Frontiers in Microbiology, 2019
Highly immunocompromised pediatric and adult hematopoietic cell transplant (HCT) recipients frequently experience respiratory infections caused by viruses that are less virulent in immunocompetent individuals. Most of these infections, with the exception
Cécile Pochon, Sebastian Voigt, Sebastian Voigt   +2 more
doaj   +1 more source

Relapse after allogeneic stem cell transplantation [PDF]

Expert Review of Hematology, 2010
Since allogeneic stem cell transplantation (SCT) represents an intensive curative treatment for high-risk malignancies, its failure to prevent relapse leaves few options for successful salvage treatment. While many patients have a high early mortality from relapse, some respond and have sustained remissions, and a minority has a second chance of cure ...
A John, Barrett, Minoo, Battiwalla
openaire   +2 more sources

Mycobacterium tuberculosis-specific and MHC class I-restricted CD8+ T-cells exhibit a stem cell precursor-like phenotype in patients with active pulmonary tuberculosis

International Journal of Infectious Diseases, 2015
The nature and longevity of the T-cell response directed against Mycobacterium tuberculosis (MTB) are important for effective pathogen containment. We analyzed ex vivo the nature of MTB antigen-specific T-cell responses directed against the MTB secreted ...
Rebecca Axelsson-Robertson, Ji Hyeon Ju, Ho-Youn Kim, Alimuddin Zumla, Markus Maeurer   +4 more
doaj   +1 more source

The efficacy and safety of allogeneic stem cell transplantation in Mevalonate Kinase Deficiency

Pediatric Rheumatology Online Journal, 2022
Objectives Mevalonate kinase deficiency (MKD) is a rare autoinflammatory syndrome. Several reports have described allogeneic hematopoietic stem cell transplantation in severely affected patients, sometimes with promising results.
Jerold Jeyaratnam, Maura Faraci, Andrew R. Gennery, Katarzyna Drabko, Mattia Algeri, Akira Morimoto, Tiarlan Sirait, Arjan C. Lankester, Michael Albert, Benedicte Neven, Joost Frenkel, on behalf of the EBMT Inborn Errors Working Party   +11 more
doaj   +1 more source

Outcomes of haploidentical stem cell transplantation for chronic lymphocytic leukemia: a retrospective study on behalf of the chronic malignancies working party of the EBMT [PDF]

, 2017
Allogeneic hematopoietic stem cell transplantation (HCT) may result in long-term disease control in high-risk chronic lymphocytic leukemia (CLL). Recently, haploidentical HCT is gaining interest because of better outcomes with post-transplantation ...
Beelen, Dietrich, Bittenbring, Jörg, Blaise, Didier, Blok, Henric-Jan, Castagna, Luca, Chevallier, Patrice, Ciceri, Fabio, Corradini, Paolo, Eikema, Dirk-Jan, Foá, Roberto, Hallek, Michael, Hilgendorf, Inken, Koc, Yener, Kröger, Nicolaus, Moreno, Carol, Müller, Lutz Peter, Schetelig, Johannes, Selleslag, Dominik, Solano, Carlos, Theobald, Matthias, Tischer, Johanna, van Gelder, Michel, van Gorkom, Gwendolyn, van Lint, M. T.   +23 more
core   +1 more source

KRAS RENAISSANCE(S) in Tumor Infiltrating B Cells in Pancreatic Cancer

Frontiers in Oncology, 2018
KRAS is a driver mutation for malignant transformation. It is found in 30% of all cancers and in 90% of pancreatic cancers. The identification of small molecules selectively inhibiting KRAS mutants has been challenging, yet mutant KRAS has recently been ...
Qingda Meng, Davide Valentini, Martin Rao, Markus Maeurer, Markus Maeurer   +4 more
doaj   +1 more source

The Role of Fecal Microbiota Transplantation in the Allogeneic Stem Cell Transplant Setting

Microorganisms, 2023
Microbiota changes during allogeneic hematopoietic stem cell transplantation has several known causes: conditioning chemotherapy and radiation, broad-spectrum antibiotic administration, modification in nutrition status and diet, and graft-versus-host ...
Elisabetta Metafuni, Luca Di Marino, Sabrina Giammarco, Silvia Bellesi, Maria Assunta Limongiello, Federica Sorà, Filippo Frioni, Roberto Maggi, Patrizia Chiusolo, Simona Sica   +9 more
doaj   +1 more source

Allogeneic Stem Cell Transplantation in Myelofibrosis [PDF]

Biology of Blood and Marrow Transplantation, 2017
Myeloproliferative neoplasm (MPN) is a category in the World Health Organization classification of myeloid tumors. BCR-ABL1-negative MPN is a subcategory that includes primary myelofibrosis (MF), post-essential thrombocythemia MF, and post-polycythemia vera MF. These disorders are characterized by stem cell-derived clonal myeloproliferation. Clinically,
Tania, Jain, Ruben A, Mesa, Jeanne M, Palmer   +2 more
openaire   +2 more sources