Results 101 to 110 of about 12,622 (280)

Allopregnanolone suppresses mechanical allodynia and internalization of neurokinin-1 receptors at the spinal dorsal horn in a rat postoperative pain model [PDF]

, 2018
BackgroundTo identify a new strategy for postoperative pain management, we investigated the analgesic effects of allopregnanolone (Allo) in an incisional pain model, and also assessed its effects on the activities of the primary afferent fibers at the ...
Fujita Masahide, Fukuda Taeko, Sato Yasuhiro, Takasusuki Toshifumi, 田中 誠, 田中 誠, 福田 妙子   +6 more
core   +2 more sources

Prenatal 17‐Alpha‐Hydroxyprogesterone Caproate Exposure in Twins and Childhood Outcomes: 14‐Year Follow‐Up of a Randomised Trial

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective Long‐term child outcomes after intra‐uterine exposure to 17‐alpha‐hydroxyprogesterone caproate (17‐OHPC) versus placebo. Design Follow‐up of the AMPHIA randomised controlled trial assessing neonatal outcomes after weekly 17‐OHPC injections compared to placebo in multiple pregnancies. Setting Multicentre. Population or Sample Children
Emilie V. J. van Limburg Stirum, Marjon A. de Boer, A. C. J. Ravelli, Rik van Eekelen, Aleid G. Leemhuis, Martijn J. J. Finken, Cornelieke S. H. Aarnoudse‐Moens, Anneloes L. van Baar, Noor E. Simons, Rebecca C. Painter, Arianne C. Lim, Ben W. Mol, Eva Pajkrt, Martijn A. Oudijk, Janneke van 't Hooft   +14 more
wiley   +1 more source

Allopregnanolone and perampanel as adjuncts to midazolam for treating diisopropylfluorophosphate‐induced status epilepticus in rats

Annals of the New York Academy of Sciences, 2020
Combinations of midazolam, allopregnanolone, and perampanel were assessed for antiseizure activity in a rat diisopropylfluorophosphate (DFP) status epilepticus model.
A. Dhir, Donald A. Bruun, M. Guignet, Yi-Hua Tsai, E. González, Jonas J. Calsbeek, Joan Vu, Naomi H. Saito, D. Tancredi, D. Harvey, P. Lein, M. Rogawski   +11 more
semanticscholar   +1 more source

The link between neurosteroids and syndromic/syndromal components of the mood spectrum disorders in women during the premenstrual phase [PDF]

, 2008
OBJECTIVES: Females with a lifetime diagnosis of major mood disorder (Bipolar Disorder BD, Major Depressive Disorder MMD) investigated during the luteal phase of their menstrual cycle and in a condition of clinical well-being showed higher blood serum
Hardoy MC, Dell'osso L, SARDU, CLAUDIA, CARTA, MAURO   +3 more
core   +1 more source

Restoration of Gut Microbiota and Metabolic Homeostasis by Lacticaseibacillus paracasei Zhang in Azithromycin‐Induced Dysbiosis

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
This study investigated whether Lacticaseibacillus paracasei Zhang could alleviate the gut microbiota imbalance and its systemic consequences caused by antibiotics. Mice treated with azithromycin exhibited gut microbiota disorders, and subsequent probiotic intervention was carried out.
Xiaoye Liu, Guoqiang Yao, Temuujin Bayarjargal, Lai‐Yu Kwok, Wenyi Zhang   +4 more
wiley   +1 more source

The estrous cycle modulates early-life adversity effects on mouse avoidance behavior through progesterone signaling

Nature Communications, 2022
Early-life adversity (ELA) increases the likelihood of neuropsychiatric diagnoses, which are more prevalent in women than men. Since changes in reproductive hormone levels can also increase the probability of anxiety disorders in women, we examined the ...
Blake J. Laham, Sahana S. Murthy, Monica Hanani, Mona Clappier, Sydney Boyer, Betsy Vasquez, Elizabeth Gould   +6 more
doaj   +1 more source

Chronic-moderate ethanol exposure of L(tk-) cells expressing ? 4? 3? GABAA receptors reduces potency of allopregnanolone potentiation of GABA-evoked inward currents: Possible role of PKC [PDF]

, 2012
Aim: To investigate the effect of chronic-moderate ethanol (CME) treatment upon direct activation and allosteric modulation of GABAA receptors, and to assess the sensitivity of these parameters to PKC inhibition in control and ethanol-treated cells ...
Barrett, I.D., Kelley, Stephen P.
core  

Endogenous neurosteroids influence synaptic GABA_A receptors during post-natal development [PDF]

, 2017
GABA plays a key role in both embryonic and neonatal brain development. For example, during early neonatal nervous system maturation, synaptic transmission, mediated by GABA A receptors (GABA ARs), undergoes a temporally specific form of synaptic ...
Agis-Balboa, Agis-Balboa, Agmon, Akk, Akk, Atack, Atack, Bahari-Javan, Banke, Baram, Belelli, Belelli, Belelli, Belelli, Ben-Ari, Ben-Ari, Ben-Ari, Ben-Ari, Bicikova, Blaesse, Bosman, Bourg, Brinton, Brown, Brown, Brown, Butt, Callachan, Cannon, Cellot, Chisari, Cossart, Craig, Crestani, Darbra, Dehorter, Deidda, Del Rio, Do Rego, Do Rego, Doischer, Farrant, Forte, Francis, Franklin, Frau, Fritschy, Gee, Girolamo, Gizerian, Glickfeld, Goldstein, Grobin, Grobin, Grobin, Grobin, Gunn, Gunn, Gunn, Harrison, Hausrat, Heim, Herd, Herd, Hoftman, Hosie, Huntsman, Ivy, Jacob, Jacobson, Jevtovic-Todorovic, Jones, Jones, Jüttner, Kanes, Kessler, Kilb, Kirmse, Korosi, Laurie, Lavoie, Le Magueresse, Lee, Lobo, Locci, Luhmann, Luhmann, Majewska, Maris, Marques-Smith, Melcangi, Mesbah-Oskui, Mody, Mòdol, Nakamura, Neuchterlein, Oh, Okada, Olsen, Olsen, Owens, Panzica, Papadopoulos, Papadopoulos, Patchev, Paysan, Peden, Peters, Pinna, Pinna, Porcu, Purdy, Reddy, Reddy, Reddy, Rice, Rovo, Rudy, Saalmann, Sauer, Schmidt, Schüle, Scioli-Salter, Sernagor, Shu, Shu, Stephens, Takahashi, Tamamaki, Teicher, Thomas, Tokuda, Tremblay, Vallée, Vallée, Vicini, Vida, Volkow, Walker, Wang, Xiao-Jing, Ye, Zhu, Zilberter, Zorumski   +144 more
core   +2 more sources

Endogenous oestrogens as neuroprotective modulators in the human retina: Evidence from transcriptomic profiling and aromatase inhibition

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Single‐cell transcriptomics reveals that the human retina expresses a broad repertoire of steroid hormone biosynthesis and estrogen signalling genes. Functional validation in retinal explants shows that local estrogen synthesis is neuroprotective, preventing photoreceptor death and limiting microglial activation. Abstract Steroid hormones, particularly
Antolin Canto, Javier Valero‐Ochando, Rosa López‐Pedrajas, Teresa Olivar, Vicente Hernández‐Rabaza, Inmaculada Almansa, María Miranda   +6 more
wiley   +1 more source

Allostatic load and preterm birth [PDF]

, 2015
Preterm birth is a universal health problem that is one of the largest unmet medical needs contributing to the global burden of disease. Adding to its complexity is that there are no means to predict who is at risk when pregnancy begins or when women ...
McCreary, J Keiko, Metz, Gerlinde AS, Ng, Jane WY, Olson, David M, Severson, Emily M, Verstraeten, Barbara   +5 more
core   +3 more sources