Results 111 to 120 of about 12,622 (280)

Refractory Status Epilepticus Treated With Bilateral Pulvinar Deep Brain Stimulation—A Case Study

Annals of Clinical and Translational Neurology, Volume 13, Issue 3, Page 627-632, March 2026.
ABSTRACT New‐onset refractory status epilepticus (NORSE) arises without an identifiable cause or prior epilepsy history, with a 16%–27% mortality rate and significant long‐term neurological sequelae. Neuromodulation such as deep brain stimulation (DBS) targeting the anterior and centromedian thalamic nuclei has shown promise when the traditional ...
Mengxuan Tang, Amerta Bai, Felipe Rodridgues Marques Ferreira, Sandipan Pati, Thaddeus Walczak, Benjamin Miller, Oladi Bentho, Thomas Henry, Ilo Leppik, Minoo Shams, Zhiyi Sha, Zachary Sanger, Theoden I. Netoff, Thomas Lisko, Anant Naik, Robert McGovern III, Sima Patel   +16 more
wiley   +1 more source

Stimulation of Peroxisome Proliferator-Activated Receptor-α by N-Palmitoylethanolamine Engages Allopregnanolone Biosynthesis to Modulate Emotional Behavior.

Biological Psychiatry, 2019
BACKGROUND The endocannabinoid and neurosteroid systems regulate emotions and stress responses. Activation of peroxisome proliferator-activated receptor (PPAR)-α by the endocannabinoid congener N-palmitoylethanolamine (PEA) regulates pathophysiological ...
A. Locci, G. Pinna
semanticscholar   +1 more source

Allopregnanolone reduces neuroendocrine response to acute stressful stimuli in sheep.

Journal of Endocrinology, 2020
The verified hypothesis assumed that centrally administered neurosteroid, allopregnanolone (AL), could affect basal and/or stress-induced activity of the hypothalamic-pituitary-adrenal (HPA) axis in sheep.
T. Misztal, P. Młotkowska, E. Marciniak, A. Misztal   +3 more
semanticscholar   +1 more source

Anti‐apoptotic effects of allopregnanolone on P19 neurons

European Journal of Neuroscience, 2006
AbstractProgesterone and its metabolites are potent allosteric modulators of GABAAreceptor function, through a direct, non‐genomic interaction with specific receptor subtypes. In addition, fluctuations in the concentration of progesterone, and allopregnanolone in particular, have been shown to modulate GABAAreceptor gene expression and activity.
Xilouri, M., Papazafiri, P.
openaire   +3 more sources

Alfaxalone anaesthesia increases brain derived neurotrophic factor levels and preserves postoperative cognition by activating pregnane-X receptors: an in vitro study and a double blind randomised controlled trial

BMC Anesthesiology, 2022
Background Alfaxalone is a fast acting intravenous anaesthetic with high therapeutic index. It is an analogue of the naturally-occurring neurosteroid allopregnanolone responsible for maintenance of cognition and neuroprotection by activation of brain ...
Juliet M. Serrao, Colin S. Goodchild
doaj   +1 more source

Fetal Pain Perception: Legislative Assertions and Developmental Neuroscience

Annals of the Child Neurology Society, Volume 4, Issue 1, Page 15-28, March 2026.
ABSTRACT Background Pain perception is a conscious experience, but neither pain nor consciousness is defined in the developing human fetus. Emergent consciousness may be regarded as a phenomenon that ultimately arises from an essential minimum of functional neuronal connectivity. Proposed U.S.
William D. Graf, Timothy M. Crombleholme, Leon G. Epstein, Dawn Gano, Phillip L. Pearl, Timothy V. Salomons, Mark S. Scher, Elise Turk, Klaus‐Peter Zimmer, Harvey B. Sarnat   +9 more
wiley   +1 more source

Research Trends and Hot Spots of Allopregnanolone Research in the Last 20 Years: A Bibliometric Analysis

Drug Design, Development and Therapy, 2023
Kunlin Guo,* Mingjie Mao,* Susu Zhang, Shiqin Xu, Liping Zhao, Xian Wang, Shanwu Feng Department of Anesthesiology, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu Province ...
Guo K, Mao M, Zhang S, Xu S, Zhao L, Wang X, Feng S   +6 more
doaj  

GABAergic neuroactive steroids: a new frontier in bipolar disorders?

Behavioral and Brain Functions, 2012
Neurosteroids are synthesized in the brain and modulate brain excitability. There is increasing evidence of their sedative, anesthetic and antiseizure properties, as well as their influence on mood.
Carta Mauro Giovanni, Bhat Krishna M, Preti Antonio   +2 more
doaj   +1 more source

The fetal brain: role of progesterone and allopregnanolone [PDF]

Hormone Molecular Biology and Clinical Investigation, 2016
Abstract Progesterone and allopregnanolone have crucial and different roles in brain development, function and recovery after injury. Pregnancy is characterized by an increased synthesis of progesterone and its neuro-active metabolites by the placenta, maternal and fetal brain.
Pluchino, Nicola, Russo, Marinella, Genazzani, Andrea R.   +2 more
openaire   +2 more sources

Neuroprotective actions of cerebellar and pineal allopregnanolone on Purkinje cells

FASEB BioAdvances, 2020
The brain produces steroids de novo from cholesterol, so‐called “neurosteroids.” The Purkinje cell, a cerebellar neuron, was discovered as a major site of the biosynthesis of neurosteroids including sex steroids, such as progesterone, from cholesterol in
Kazuyoshi Tsutsui, Shogo Haraguchi
doaj   +1 more source