Results 131 to 140 of about 12,622 (280)

Association of serum allopregnanolone with restricted and repetitive behaviors in adult males with autism.

Psychoneuroendocrinology, 2020
Autism spectrum disorder (ASD) has been associated with imbalance between excitatory and inhibitory (E/I) neurotransmission systems, as well as with neuroinflammation.
Leila Chew, Kevin L. Sun, Wenchao Sun, Zhe Wang, Jayakumar Rajadas, Ryan E. Flores, E. Arnold, Booil Jo, Lawrence K. Fung   +8 more
semanticscholar   +1 more source

The Role of Allopregnanolone Levels in Traumatic Brain Injury in Children and Adults and the Correlation of Its Levels with Computerized Tomography Images of the Brain

Indian Journal of Neurosurgery, 2020
Aim Allopregnanolone (AP) is a steroid of progesterone origin and it can readily pass through the blood–brain barrier. The aim of this study was to determine the AP levels occurring after head trauma in children and adults and to compare these results to
Göker Coskun, Nesrin Gökben Beceren, Cihan Bedel   +2 more
doaj   +1 more source

Nestorone® as a Novel Progestin for Nonoral Contraception:Structure-Activity Relationships and Brain Metabolism Studies [PDF]

, 2017
Nestorone® (NES) is a highly potent non-androgenic progestin being developed for contraception. NES is a synthetic progestin that may possess neuroprotective and myelin regenerative potential as an added health benefits.
Alanah R. Knibb, Attardi, Belelli, Belelli, Brinton, Brown, Brown, Callachan, Celotti, Davies, El-Etr, Gago, Garay, Haukkamaa, Heikinheimo, Heikinheimo, Hussain, Isabelle Petit-Topin, Jeremy J. Lambert, Jerôme Fagart, Kumar, Lambert, Lambert, Liere, Liu, Liu, Lähteenmäki, Marie-Edith Rafestin-Oblin, Marion Rame, Martine El-Etr, Matias, Meffre, Michael Schumacher, Narender Kumar, Noé, Pereira de Jésus-Tran, Petit-Topin, Petit-Topin, Philippe Liere, Regine Sitruk-Ware, Schumacher, Schüle, Scott J. Mitchell, Sitruk-Ware, Sitruk-Ware, Sitruk-Ware, Sivin, Stanczyk, Tuba, Williams, Winneker, Wong   +51 more
core   +2 more sources

Beyond the streetlight: a TREAT‐AD perspective on where to find new Alzheimer's targets

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract Despite extensive investments in Alzheimer's disease (AD) therapeutic development, progress toward effective interventions remains modest. The landscape of potential novel therapeutic strategies is rapidly growing, but prioritization, validation, and tools to advance targets to trial are lagging.
Gregory A. Cary, Jesse C. Wiley, Gregory W. Carter, Allan I. Levey   +3 more
wiley   +1 more source

Antioxidant and Anti-Apoptotic Properties of Allopregnanolone in Protecting Dopaminergic Neurons from 6-OHDA-Induced Injury [PDF]

Veterinary and Comparative Biomedical Research
Dopaminergic neurodegeneration is associated with oxidative stress, mitochondrial dysfunction, neuroinflammation, and cell death. Allopregnanolone, a multifunctional neurosteroid, is involved in various biological processes within the body.
Hossein Khodadadi, Hossein Jonaidi, Saeed Esmaeili-Mahani, Mehran Pourmashayekhi, Parsa Jonaidi   +4 more
doaj   +1 more source

Allopregnanolone Modulates GABAAR-Dependent CaMKIIδ3 and BDNF to Protect SH-SY5Y Cells Against 6-OHDA-Induced Damage

Frontiers in Cellular Neuroscience, 2020
Allopregnanolone (APα), as a functional neurosteroid, exhibits the neuroprotective effect on neurodegenerative diseases such as Parkinson’s disease (PD) through γ-aminobutyric acid A receptor (GABAAR), but it has not been completely understood about its ...
Tongtong Wang, Tongtong Wang, Xin Ye, Xin Ye, Wei Bian, Wei Bian, Zhichi Chen, Zhichi Chen, Juanjuan Du, Juanjuan Du, Mengyi Li, Mengyi Li, Peng Zhou, Peng Zhou, Huairui Cui, Huairui Cui, Yu-Qiang Ding, Shuangshuang Qi, Min Liao, Min Liao, Chenyou Sun, Chenyou Sun   +21 more
doaj   +1 more source

Dissociating Allopregnanolone Mnemonic Effects from Sedation [PDF]

, 2012
Allopregnanolone (Allop) is a neurosteroid metabolite of progesterone. Allop modulates cognition, specifically learning and memory, but these effects are frequently confounded by its anxiolytic and sedative properties.
Hartman, Sarah B
core   +1 more source

Protocadherin 19 (PCDH19) interacts with paraspeckle protein NONO to co-regulate gene expression with estrogen receptor alpha (ERalpha) [PDF]

, 2017
De novo and inherited mutations of X-chromosome cell adhesion molecule protocadherin 19 (PCDH19) cause frequent, highly variable epilepsy, autism, cognitive decline and behavioural problems syndrome.
Corbett, M., Fox, A., Gecz, J., Homan, C., Kolc, K.L., Kumar, R., McAninch, D., Pham, D., Tan, C., Thomas, P.   +9 more
core   +1 more source

Procedural separation of appetitive and consummatory behaviors in operant ethanol self‐administration: A review and open‐source analytical framework

Alcohol, Clinical and Experimental Research, Volume 50, Issue 2, February 2026.
This review highlights the biphasic sipper model pioneered by Dr. Hank Samson's laboratory, which separates appetitive and consummatory behaviors in rodent ethanol self‐administration. Over two decades of research using this paradigm reveals that alcohol‐directed behaviors are dynamic, shaped by internal states, cues, and experience.
Olivia A. Colarusso, Jeffrey L. Weiner
wiley   +1 more source

Prenatal Stress Alters Progestogens to Mediate Susceptibility to Sex-Typical, Stress-Sensitive Disorders, such as Drug Abuse: A Review [PDF]

, 2011
Maternal-offspring interactions begin prior to birth. Experiences of the mother during gestation play a powerful role in determining the developmental programming of the central nervous system. In particular, stress during gestation alters developmental
Cheryl A Frye, Cheryl A Frye, Cheryl A Frye, Cheryl A Frye, Jason J Paris, Danielle eOsborne, Joanna eCampbell, Tod eKippin   +7 more
core   +1 more source