Results 111 to 120 of about 61,179 (292)

A randomized controlled study of allopurinol mouthwash in the prevention of 5-fluorouracil-induced oral mucositis

Journal of Health Science and Medical Research (JHSMR), 2009
Objectives: To formulate an allopurinol suspension; study the chemical and physical stability of the formulation and compare the efficacy and adverse drug reactions of a 5 mg/mL allopurinol mouthwash with a placebo in the prevention of 5-fluorouracil (5 ...
P Kaewmanee, P Wongpoowarak, P Sunpaweravong, S Kasiwong, W Wongpoowarak   +4 more
doaj  

Comparative cardiovascular risk of allopurinol versus febuxostat in patients with gout: a nation-wide cohort study.

Rheumatology, 2019
OBJECTIVE To compare cardiovascular (CV) risk among gout patients initiating allopurinol vs febuxostat. METHODS Using 2002-2015 Korean National Health Insurance Service data for the entire Korean population, we conducted a cohort study on gout patients
E. Kang, Hyon K. Choi, A. Shin, Y. Lee, E. Lee, Y. Song, Seoyoung C. Kim   +6 more
semanticscholar   +1 more source

Lesinurad in combination with allopurinol: a randomised, double-blind, placebo-controlled study in patients with gout with inadequate response to standard of care (the multinational CLEAR 2 study). [PDF]

, 2016
Determine the efficacy and safety of daily lesinurad (200 or 400 mg orally) added to allopurinol in patients with serum uric acid (sUA) above target in a 12-month, randomised, phase III trial.
Adler, S., Bardin, T., Baumgartner, S., Bhakta, N., Fung, M., Keenan, R.T., Khanna, P.P., Kopicko, J., So, A., Storgard, C.   +9 more
core   +1 more source

Nitrite supplementation alleviates cerebrovascular dysfunction in chronically stressed mice, but cognitive decline remains

Experimental Physiology, EarlyView.
Abstract This study aimed to determine whether sodium nitrite supplementation prevented chronic stress‐induced cerebrovascular dysfunction and cognitive decline. We hypothesize that nitrite supplementation will prevent the oxidative environment and cerebrovascular dysfunction associated with chronic stress and maintain cognitive health.
Emily Burrage, Tyler Coblentz, Saina S. Prabhu, Nicole M. Eminhizer, Ryan Childers, Randall W. Bryner, Sara E. Lewis, Brooke A. Maxwell, Evan R. DeVallance, Eric E. Kelley, Paul D. Chantler   +10 more
wiley   +1 more source

2448 The effect of allopurinol on pediatric patients undergoing maintenance chemotherapy for acute lymphoblastic leukemia or lymphoblastic lymphoma

Journal of Clinical and Translational Science, 2018
OBJECTIVES/SPECIFIC AIMS: This study aims to assess the safety, feasibility, clinical benefits and pharmacodynamics of adding allopurinol to standard maintenance therapy that includes 6-mecaptopurine (6-MP) in pediatric patients with acute lymphoblastic ...
Mariam M. Bhuiyan, Gordon Cohen, Stacy Cooper   +2 more
doaj   +1 more source

A novel drug management system in the Febuxostat versus Allopurinol Streamlined Trial:A description of a pharmacy system designed to supply medications directly to patients within a prospective multicenter randomised clinical trial [PDF]

, 2016
Background: Trials of investigational medicinal products are required to adhere to strict guidelines with regard to the handling and supply of medication.
Flynn, Robert W V, Macdonald, Thomas M., Mackenzie, Isla S., McDonnell, Patrick, Rogers, Amy   +4 more
core   +2 more sources

Machine learning methods for predicting adverse drug events: A systematic review

British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 422-444, February 2026.
Abstract Predicting adverse drug events (ADEs) in outpatient settings is crucial for improving medication safety, identifying high‐risk patients and reducing health‐care costs. While traditional methods struggle with the complexity of health‐care data, machine learning (ML) models offer improved prediction capabilities; however, their effectiveness in ...
Niaz Chalabianloo, Fatemeh Ahmadi, Mohammad Ali Omrani, Sheikh S. Abdullah, Neda Rostamzadeh, Atefeh Jafari, Lujain Izzedin, Kamran Sedig, Flory T. Muanda   +8 more
wiley   +1 more source

Multicentre, prospective, randomised, open-label, blinded end point trial of the efficacy of allopurinol therapy in improving cardiovascular outcomes in patients with ischaemic heart disease: protocol of the ALL-HEART study [PDF]

, 2016
Introduction Ischaemic heart disease (IHD) is one of the most common causes of death in the UK and treatment of patients with IHD costs the National Health System (NHS) billions of pounds each year. Allopurinol is a xanthine oxidase inhibitor used to
ALL-HEART Study Group, Avery, Anthony, Begg, Alan, Ford, Ian, Hawkey, Chris, MacDonald, Thomas M., Mackenzie, Isla S., Struthers, Allan D., Taggar, Jaspal, Walker, Andrew, Wei, Li   +10 more
core   +5 more sources

Artemisia selengensis Leaves, a Vegetable Waste: LC‐MS‐Based Chemical Profiling, Ultrasound‐Assisted DES Extraction, and Xanthine Oxidase Inhibitory Activity

eFood, Volume 7, Issue 1, February 2026.
This study focused on Artemisia selengensis leaves (ASL), a discarded agricultural waste. 72 compounds were identified by UPLC‐Q‐TOF‐MS. “Green” extraction with DES was optimized, and ASL's XO—inhibition was explored, presenting new ways for waste utilization. ABSTRACT Artemisia selengensis is a medicinal and edible plant, whose tender stems are widely
Lixia Li, Mingqiu Shan, Rongli Qiu, Sheng Yu, Ting Geng, Li Zhang, Xinli Liang, Baoxiang Wu, Facheng Zhang   +8 more
wiley   +1 more source

Assessment on the use of allopurinol to improve safety and efficacy of mercaptopurine in pediatric patients with Acute Lymphoblastic Leukemia and Lymphoma during maintenance therapy

Cancer Reports
Background Mercaptopurine is an important component of acute lymphoblastic leukemia (ALL) and lymphoma (LLy) maintenance therapy. The 6‐thioguanine nucleosides (6‐TGN) are believed to be the primary contributor to myelosuppression and immunosuppressive ...
Tecca Barone, Smita Dandekar, Daniel McKeone, Kevin Mulieri   +3 more
doaj   +1 more source