Results 121 to 130 of about 26,198 (235)

Repurposing Purine Analog Antivirals to Modulate Serum Uric Acid: Evidence From Real‐World Data

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Xanthine oxidase (XO) inhibitors remain the standard pharmacologic therapy for hyperuricemia. However, additional enzymatic components of the purine degradation pathway may contribute to uric acid synthesis. Guanine deaminase (GD) catalyzes the conversion of guanine to xanthine, providing substrate for downstream oxidation by XO.
Joseph Magagnoli, Tammy H. Cummings, Michael D. Wyatt, Campbell McInnes, Jayakrishna Ambati, S. Scott Sutton   +5 more
wiley   +1 more source

Prevention effect of allopurinol on PEP.

, 2014
Prevention effect of allopurinol on PEP.
Wen-Shan Yan (627625), Xiao-Hui Xiang (627626), Wei-Li Cao (627624), Shi-Hai Xia (627627), Kai Chen (129938)   +4 more
core   +1 more source

CYP2E1 and CYP2D6 in Anti‐Tuberculosis Drug‐Induced Liver Injury: Mechanisms, Epigenetic Regulation, and Translational Implications

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Tuberculosis (TB) continues to be a significant global health issue, with anti‐tuberculosis drug‐induced liver injury (ATDILI) representing the most frequent and severe adverse event associated with first‐line therapy. Despite extensive investigation, the mechanistic basis of ATDILI remains incompletely understood.
Pathida Prakongsup, Wanvisa Udomsinprasert   +1 more
wiley   +1 more source

Allopurinol for fetal neuro- and cardiovascular protection

, 2014
The studies presented in this thesis indicate that maternally administered allopurinol rapidly crosses the placenta, is effective in suppressing xanthine oxidase activity, has little adverse side effects (as long as clinically compatible dosages are used)
Kaandorp, J.J.
core  

Allopurinol inappropriate use in case of asymptomatic hyperuricemic patient causes fatal Allopurinol hypersensitive syndrome: lesson to all

, 2017
Allopurinol is used to treat hyperuricemia (HU) in a patient of gout. It is also used to prevent HU in a patient of hematological malignancies who are about to undergo chemotherapy.
Sharma, Reena, Chaudhary, Usha Kumari, Kumar, Arvind, Kansal, Dinesh, Sharma, Ajay   +4 more
core   +1 more source

Severe Thiopurine‐Induced Myelosuppression in a Pediatric Acute Lymphoblastic Leukemia Patient With the NUDT15 *1/*6 Genotype: A Brief Report

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Variants in TPMT and NUDT15 genes that affect thiopurine metabolism can guide personalized dosing to minimize toxicity. Decreased or no appreciable NUDT15 activity demonstrates impaired breakdown of active thiopurine metabolites which can lead to severe adverse events including potentially life‐threatening myelosuppression.
Jillian Fry, Erin C. Boone, Wendy Y. Wang, Shobana John, Lisa A. Lansdon, Midhat S. Farooqi, Byunggil Yoo, Andrea Gaedigk, Keith August, Terrie G. Flatt, Laura B. Ramsey   +10 more
wiley   +1 more source

Reduction of uric acid production following multiple allopurinol administrations.

, 2012
(A) Simulated venous plasma and intrahepatic concentration profiles of allopurinol and oxypurinol are in agreement with experimental PK data [43]. (B) Prediction of venous plasma and intrahepatic concentration profiles of allopurinol and oxypurinol after
Jörg Lippert (124210), Lars Kuepfer (31319), Steffen Borchers (124204), Markus Krauss (124200), Stephan Schaller (124202), Rolf Findeisen (124207)   +5 more
core   +1 more source

Redox Imbalance and NOS‐Dependent Modulation of Superoxide in the Bladder Mucosa of Women With IC/BPS: A Preliminary Study

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a chronic condition characterized by bladder/pelvic pain and urinary symptoms, with poorly defined mechanisms and no reliable biomarkers. Oxidative stress, particularly reactive oxygen species (ROS), has been implicated in its pathophysiology, but direct human evidence remains scarce ...
Mariana G. de Oliveira, Edson Antunes, Gabriela Reolon Passos, Luiz Gustavo Oliveira Brito, Carlos Arturo Levi D'Ancona, Fabíola Z. Monica   +5 more
wiley   +1 more source

Multicentre study and systematic review: Allopurinol exposure during pregnancy [PDF]

BACKGROUND: Data about the safety of allopurinol in pregnant women are sparsely reported. AIMS: To investigate the risk of adverse pregnancy outcome and congenital abnormalities after in utero exposure to allopurinol in inflammatory bowel disease (IBD ...
Crouwel, Femke, Kuijvenhoven, Johan P, de Boer, Nanne K, Simsek, Melek, van Asseldonk, Dirk P, Bhalla, Abha, Oldenburg, Bas, Julsgaard, Mette, de Boer, Marjon A, Gilissen, Lennard P L, Buiter, Hans J C, Verburg, Robert J, Mares, Wout G N, Weusthuis, Angelique L M, Jharap, Bindia   +14 more
core  

The role of allopurinol on oxidative stress in experimental hyperthyroidism

, 2009
Aim: During hyperthyroidism, production of free oxygen radicals derives, where xanthine oxidase may also play an important role. Allopurinol, a xanthine oxidase inhibitor, has a significant effect on thyrotoxicosis-related oxidative stress.
Icoz, G., Makay, O., Akyildiz, M., Ozgen, G., Simsek, N. Genc, Yenisey, C., Yetkin, E.   +6 more
core   +1 more source