Results 111 to 120 of about 26,198 (235)
eJHaem, Volume 7, Issue 3, June 2026.ABSTRACT Andersen–Tawil syndrome (ATS) is a rare, hereditary channelopathy characterized by periodic paralysis, cardiac arrhythmias, and sometimes developmental anomalies. No association with hematologic malignancies has previously been reported. We describe the case of a 27‐year‐old man with genetically confirmed Type 1 ATS who developed T‐cell acute ...
Ramy Rahmé +6 more
wiley +1 more source
Successful desensitization for treatment of an exfoliative dermatitis to allopurinol
, 1999 Allopurinol is widely used for chronic tophaceous gout as a uric acid lowering agent. Hyperse- nsitivity to allopurinol occurrs in about 10% of patients, which limits the usage of allopurinol.
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JEADV Clinical Practice, Volume 5, Issue 2, Page 577-580, June 2026.ABSTRACT Background Epidermal necrolysis (EN), including Stevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), are severe cutaneous drug reactions with high morbidity. However, the quality of life (QoL) impact during acute hospitalization is not well understood.
Jacob McFeeters +9 more
wiley +1 more source
Uric Acid in Metabolic Dysfunction‐Associated Steatotic Liver Disease
Portal Hypertension &Cirrhosis, Volume 5, Issue 2, Page 189-206, June 2026.MASLD is the most prevalent chronic liver disease worldwide, yet effective pharmacological treatments remain limited. Hyperuricemia is now recognized as a key driver of hepatic steatosis, inflammation, and fibrosis, with elevated serum uric acid levels independently predicting hepatocellular carcinoma and liver‐related mortality.
Rong Wang +5 more
wiley +1 more source
Benzofuran‐Based Uricosuric Agents: History, Roles, and Challenges
ChemistrySelect, Volume 11, Issue 24, 25 June 2026.Benzofuran‐based uricosuric agents represent a privileged medicinal chemistry scaffold for gout therapy. Structural optimization of benzbromarone‐related derivatives has improved hURAT1 inhibitory potency, metabolic stability, and urate‐lowering efficacy, while reducing hepatotoxic liability.
Raed M. Al‐Zoubi +7 more
wiley +1 more source
BMJ OpenObjectives To investigate the impact of allopurinol use on the risk of first-ever acute coronary syndrome (ACS) event in patients with gout.Methods Using national and regional register data, we included all patients with a gout diagnosis at primary or ...
Ulf Lindström +5 more
doaj +1 more source
Contact Dermatitis, Volume 94, Issue 6, Page 677-688, June 2026.This study provides reassuring evidence in favour of early skin testing in patients with SCARs, argues against the necessity of a 6‐month delay, and underscores the pivotal role of oral provocation tests in the safe reintroduction of essential therapies. ABSTRACT Background Identifying and discontinuing the offending drug(s) in severe cutaneous adverse
Zohra Chadli +8 more
wiley +1 more source
Allopurinol-induced effects in premature baboons with respiratory distress syndrome
, 1991 To test the hypothesis that administration of allopurinol could modify the response to prolonged hyperoxia in premature baboons (140 days gestation) with respiratory distress syndrome, we evaluated physiological, pathological, and lung biochemical ...
D. R. Gerstmann +7 more
core +1 more source
Associations between Allopurinol and Cardiovascular and Renal Outcomes in Diabetes
, 2020 Diabetes is a leading cause of cardiovascular and kidney disease, and novel therapies to reduce these adverse diabetes outcomes are urgently required.
Weisman, Alanna
core +1 more source