Results 101 to 110 of about 26,198 (235)

Pharmacokinetic Drug–Drug Interaction Potential of Oral Anticancer Drugs

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1614-1627, June 2026.
Drug–drug interaction (DDI) management is critical for safe and effective use of oral anticancer drugs (OADs). Our study objectives were to (i) compile clinically relevant pharmacokinetic (PK) DDI mechanisms for OADs and (ii) assess the prevalence of PK potential DDIs (PDDIs) in patients with advanced solid cancers.
Fatimah Alhurayri, Islam R. Younis, Shadia I. Jalal, Theodore F. Logan, Rohan Maniar, Steven M. Bray, Sara K. Quinney, Zeruesenay Desta, Todd C. Skaar, James E. Tisdale, Tyler Shugg   +10 more
wiley   +1 more source

Combined Anserine/Carnosine Exerts Anti‐Hyperuricemic, Nephroprotective, and Gut Microbiota‐Modulating Effects in Hyperuricemia Mice

Food Bioengineering, Volume 5, Issue 2, Page 194-208, June 2026.
Mixed carnosine and anserine significantly reduce serum uric acid, protect the kidneys, and modulate gut microbiota, demonstrating potent therapeutic potential against hyperuricemia. ABSTRACT The anti‐hyperuricemic, nephroprotective, and gut microbiota modulation effects of mixed carnosine and anserine (MAC) with the fixed ratio of 10:1 were evaluated ...
Jingjing Huang, Zheng Dang, Yuzhi Zhang, Haisheng Lin, Lei Du, Jie Zhang, Li Zhao, William T. H. Chang, Xiang‐Ru Kong, Wei‐Ting Tseng, Jingli Xie   +10 more
wiley   +1 more source

Comparative clinical efficiency of resveratrol, allopurinol, and resveratrol plus allopurinol in canine visceral leishmaniasis

Objective To assess the clinical and immunological effectiveness of resveratrol alone or combined with allopurinol for treating canine visceral leishmaniasis (CVL). Methods This study included 50 dogs, 30 diagnosed with CVL and 20 healthy controls.
Gultekin, Mehmet, Pasa, Serdar, Gunal, Ismail, Erdogan, Songul, Ozalp, Tahir, Ayan, Adnan, Balikci, Canberk, Ural, Kerem, Erdogan, Hasan   +8 more
core   +1 more source

Individualising the dose of allopurinol in patients with gout

, 2017
Aims: The aims of the study were to: 1) determine if a plasma oxypurinol concentration-response relationship or an allopurinol dose-response relationship best predicts the dose requirements of allopurinol in the treatment of gout; and 2) to construct a ...
Lisa K. Stamp, Sophie L. Stocker, Garry G. Graham, Daniel F. B. Wright, Stamp, Lisa K., Wright, Daniel F., Ian Portek, Portek, Ian J., Stocker, Sophie L., Richard O. Day, Kannangara, Diluk R., Williams, Kenneth M., Pile, Kevin (R17082), Murray L. Barclay, Barclay, Murray L., Day, Richard O., Kevin D. Pile, Graham, Garry G., Diluk R. W. Kannangara, Kenneth M. Williams   +19 more
core   +1 more source

Association between allopurinol and hepatocellular carcinoma: analysis of genetic risk and patient survival

Discover Oncology
Background Despite the widespread clinical use of allopurinol for managing hepatocellular carcinoma (HCC) and gout, its potential hepatotoxicity and its effect on the risk of HCC remain unclear.
Yu-fu Li, Hui-wei Wang, Huan-yan Peng, Zhen-ying Zhang, Zhi-jia Yao, Yuan Meng, Dong-ye Yang   +6 more
doaj   +1 more source

Effectiveness of Allopurinol on Uric Acid and Pediatric Chronic Kidney Disease Severity in the Chronic Kidney Disease in Children Study

Kidney Medicine
Rationale & Objective: Clinical trials have shown that serum uric acid reduction does not slow chronic kidney disease (CKD) progression in adults, but it is uncertain whether these findings apply to children.
Derek K. Ng, Matthew B. Matheson, George J. Schwartz, Katherine E. Kurgansky, Bradley A. Warady, Susan L. Furth   +5 more
doaj   +1 more source

Antihyperuricemic Effect of Hawthorn Flavonoid Vitexin: LC–MS Analysis, Network Pharmacology, and In Vivo Verification of Molecular Mechanisms

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
UPLC‐MS/MS analysis of hawthorn flavonoids combined with network pharmacology, molecular docking, and molecular dynamics studies predicted vitexin as a key compound acting on the PPARγ/ABCG2 pathway. In a hyperuricemic mouse model, vitexin effectively lowered serum uric acid by enhancing renal and intestinal urate excretion, inhibiting urate production,
Shu‐Yu Wu, Kai‐Wen Kang, Dan‐Yu Huang, Shu‐Ying Li, Hao Zheng, Ri‐Hui Wu, Hui‐Qing Lv, Wan‐Bin Song, Jing Chen, Cheng‐Ping Wen, Li‐She Gan, Xiao Yuan   +11 more
wiley   +1 more source

Eucalyptus camaldulensis Extract Mediated Green Synthesis of Iron Oxide Nanoparticles and In Vitro and In Vivo Biological Screening, and Detailed Molecular Docking Analysis

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Eucalyptus camaldulensis extract mediated green synthesis of IONPs and In vitro and In vivo Biological Screening, and Detailed Molecular Docking Analysis. ABSTRACT Natural products and their secondary metabolites have long been known as good bioresources in the synthesis of nanomaterials.
Abdur Rauf, Arshad Iqbal, Shahkar Usama, Imran Ullah, Walaa F. Alsanie, Abdulhakeem S. Alamri, Zuneera Akram, Rahaf Ajaj, Naveed Muhammad, Zubair Ahmad, Jaseem Ahmad, Mohammed Mansour Quradha   +11 more
wiley   +1 more source

Allopurinol use and risk of multiple sclerosis

BackgroundLow uric acid levels have been observed in patients with multiple sclerosis (MS). As allopurinol is commonly used to lower uric acid in gout patients, this study examined allopurinol use in individuals with MS during the five years before ...
Framke, Elisabeth, Horwitz, Henrik, Windfeld-Mathiasen, Josefine, Heerfordt, Ida M., Magyari, Melinda   +4 more
core   +1 more source

Effects of allopurinol and vitamin E on renal function in patients with cardiac coronary artery bypass grafts

, 2009
Nader Nouri-Majalan1, Ehsan Fotouhi Ardakani2, Khalil Forouzannia3, Hosein Moshtaghian41Department of Nephrology, 3Department of Cardiovascular Surgery, 4Department of Anesthesiology, Afshar Hospital, Shahid Sadoughi University of Medical Sciences, Yazd,
Khalil Forouzannia, Hosein Moshtaghian, Nader Nouri-Majalan, Ehsan Fotouhi Ardakani   +3 more
core