Results 31 to 40 of about 61,179 (292)
Frontiers in Medicine, 2021 Background: Hyperuricemia is a common metabolic disease and has become a public health problem because of its increasing prevalence and association with comorbidities.
Shengzhao Zhang +6 more
semanticscholar +1 more source
A case series of allopurinol-induced toxic epidermal necrolysis
Indian Journal of Dermatology, 2011 This is a case series of allopurinol-induced toxic epidermal necrolysis. Revisiting the indications of using allopurinol in asymptomatic hyperuricemia and a critical reappraisal of the safety profile of allopurinol is done in this article.
Harneet Ranu +2 more
doaj +1 more source
Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial [PDF]
, 2008 <p><b>Background and Purpose</b>: Elevated serum uric acid level is associated with poor outcome and increased risk of recurrent events after stroke.
Dawson, J. +6 more
core +1 more source
The role of urate and xanthine oxidase in vascular oxidative stress:Future directions [PDF]
, 2009 Vascular oxidative stress has been shown to be a potent factor in the pathophysiology of endothelial dysfunction. Despite current optimal evidence-based therapy, mortality from various cardiovascular disorders remains high.
George, Jacob, Struthers, Allan
core +5 more sources
Frontiers in Pharmacology, 2018 Background: Allopurinol-induced severe cutaneous adverse reactions (SCARs), including drug rash with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN), are life-threatening autoimmune reactions.
Bao Sun +25 more
doaj +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Evaluation of the effect of allopurinol as a protective factor in post ischemia and reperfusion inflammation in Wistar rats [PDF]
Acta Cirúrgica Brasileira, 2016 PURPOSE: To investigate the potential protective effect of allopurinol on reperfusion injury by determining the inflammatory response through the measurement of tumor necrosis factor-alpha (TNF-alpha).
Ricardo Zanetti Gomes +4 more
doaj +1 more source
, 2008 INTRODUCTION: Gout affects about 5% of men and 1% of women, with up to 80% of people experiencing a recurrent attack within 3 years. METHODS AND OUTCOMES:We conducted a systematic review and aimed to answer the following clinical questions: What are the
Underwood, Martin
core +3 more sources
Examining the use of allopurinol: Perspectives from recent drug injury relief applications
Journal of the Formosan Medical Association, 2019 Background/purpose: Previous studies have reported that the indication and starting dose of allopurinol may be associated with the incidence of hypersensitive reactions.
Chu-Han Huang, Mei-Pei Chu, Wen-Wen Chen
doaj +1 more source
Skin rash, eosinophilia, and renal impairment in a patient recently started on allopurinol
Journal of Family Medicine and Primary Care, 2016 Allopurinol is a hypoxanthine analog which inhibits xanthine oxidase, it is a widely used medication for the treatment of hyperuricemia and gout. Allopurinol-induced drug-induced rash with eosinophilia and systemic symptoms syndrome is an infrequent ...
Ashraf Jmeian +4 more
doaj +1 more source