Results 31 to 40 of about 58,710 (306)
Frontiers in Pharmacology, 2018 Background: Allopurinol-induced severe cutaneous adverse reactions (SCARs), including drug rash with eosinophilia and systemic symptoms (DRESS), Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN), are life-threatening autoimmune reactions.
Bao Sun +25 more
doaj +1 more source
Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial [PDF]
, 2008 <p><b>Background and Purpose</b>: Elevated serum uric acid level is associated with poor outcome and increased risk of recurrent events after stroke.
Dawson, J. +6 more
core +1 more source
Evaluation of the effect of allopurinol as a protective factor in post ischemia and reperfusion inflammation in Wistar rats [PDF]
Acta Cirúrgica Brasileira, 2016 PURPOSE: To investigate the potential protective effect of allopurinol on reperfusion injury by determining the inflammatory response through the measurement of tumor necrosis factor-alpha (TNF-alpha).
Ricardo Zanetti Gomes +4 more
doaj +1 more source
Journal of Cardiovascular Development and Disease, 2023 Background: The effects of allopurinol in patients with cardiovascular disease are not well defined; therefore, the latest evidence is summarized in this study. Methods: PubMed, Embase, Cochrane Library, and ClinicalTrials.gov databases were searched for
Yuyang Ye +6 more
doaj +1 more source
The role of urate and xanthine oxidase in vascular oxidative stress:Future directions [PDF]
, 2009 Vascular oxidative stress has been shown to be a potent factor in the pathophysiology of endothelial dysfunction. Despite current optimal evidence-based therapy, mortality from various cardiovascular disorders remains high.
George, Jacob, Struthers, Allan
core +4 more sources
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Solubility and Permeability Improvement of Allopurinol by Cocrystallization
Crystal Growth & Design, 2020 Allopurinol is a xanthine oxidase inhibitor with poor solubility and permeability, which severely limit its drug absorption following the administration of some dosage forms, such as tablets and re...
Xia-Lin Dai +6 more
semanticscholar +1 more source
Allopurinol Induction on Histopathological Structure of the Liver in Male Mice (Mus musculus)
Jurnal Biodjati, 2022 Allopurinol is used to reduce total uric acid levels in the body into oxypurinol which can inhibit xanthine oxidase. Allopurinol inhibits the precursors of uric acid formation, xanthine, and hypoxanthine.
Dian Fita Lestari +3 more
doaj +1 more source
Skin rash, eosinophilia, and renal impairment in a patient recently started on allopurinol
Journal of Family Medicine and Primary Care, 2016 Allopurinol is a hypoxanthine analog which inhibits xanthine oxidase, it is a widely used medication for the treatment of hyperuricemia and gout. Allopurinol-induced drug-induced rash with eosinophilia and systemic symptoms syndrome is an infrequent ...
Ashraf Jmeian +4 more
doaj +1 more source
, 2008 INTRODUCTION: Gout affects about 5% of men and 1% of women, with up to 80% of people experiencing a recurrent attack within 3 years. METHODS AND OUTCOMES:We conducted a systematic review and aimed to answer the following clinical questions: What are the
Underwood, Martin
core +3 more sources