Results 11 to 20 of about 2,738 (186)
Evolution of Allorecognition in the Tunicata [PDF]
Biology, 2020 Allorecognition, the ability to distinguish self or kin from unrelated conspecifics, plays several important biological roles in invertebrate animals. Two of these roles include negotiating limited benthic space for colonial invertebrates, and inbreeding
Marie L. Nydam
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Advanced ScienceIn solid organ transplantation, monocytes and macrophages play a cross‐cutting role in the rejection process, irrespective of the transplanted tissue and the type of rejection. Here, we integrated multiple single‐cell assays (>150,000 cells) with a broad
Alexis Varin +16 more
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Innate Allorecognition and Memory in Transplantation [PDF]
Frontiers in Immunology, 2020 Over the past few decades, we have witnessed a decline in the rates of acute rejection without significant improvement in chronic rejection. Current treatment strategies principally target the adaptive immune response and not the innate response ...
Daqiang Zhao +10 more
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Allorecognition by T lymphocytes and allograft rejection [PDF]
Frontiers in Immunology, 2016 Recognition of donor antigens by recipient T cells in secondary lymphoid organs initiates the adaptive inflammatory immune response leading to the rejection of allogeneic transplants.
Gilles Benichou +2 more
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TCR cross-reactivity and allorecognition: new insights into the immunogenetics of allorecognition [PDF]
Immunogenetics, 2011 Alloreactive T cells are core mediators of graft rejection and are a potent barrier to transplantation tolerance. It was previously unclear how T cells educated in the recipient thymus could recognize allogeneic HLA molecules. Recently it was shown that both naïve and memory CD4+ and CD8+ T cells are frequently cross-reactive against allogeneic HLA ...
Lloyd D’Orsogna +3 more
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Transfusion Clinique et Biologique, 2001 Until recently, the vigorous T cell response via the direct pathway has overshadowed studies involving the indirect pathway. Thus, while the direct pathway has previously been considered to be the main driving force in alloimmune responses, there is an increasing body of data to support a prominent role of the indirect pathway in transplant rejection ...
Nicola J. Rogers, Robert I. Lechler
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Proteomic analysis of the sponge Aggregation Factor implicates an ancient toolkit for allorecognition and adhesion in animals. [PDF]
Proc Natl Acad Sci U S ARuperti F +6 more
europepmc +3 more sources
het-B allorecognition in Podospora anserina is determined by pseudo-allelic interaction of genes encoding a HET and lectin fold domain protein and a PII-like protein. [PDF]
PLoS GeneticsFilamentous fungi display allorecognition genes that trigger regulated cell death (RCD) when strains of unlike genotype fuse. Podospora anserina is one of several model species for the study of this allorecognition process termed heterokaryon or ...
Corinne Clavé +4 more
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Allorecognition mechanisms during ascidian fertilization [PDF]
The International Journal of Developmental Biology, 2008 Ascidians (primitive chordates) are hermaphroditic animals, releasing sperm and eggs nearly simultaneously. But, many ascidians, including Ciona intestinalis and Halocynthia roretzi, show self-sterility or preference for cross-fertilization rather than self-fertilization.
Yoshito Harada, Hitoshi Sawada
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The greenbeard gene tgrB1 regulates altruism and cheating in Dictyostelium discoideum [PDF]
Nature CommunicationsGreenbeard genetic elements encode rare perceptible signals, signal recognition ability, and altruism towards others that display the same signal. Putative greenbeards have been described in various organisms but direct evidence for all the properties in
Mariko Katoh-Kurasawa +2 more
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