Results 11 to 20 of about 3,437 (186)
Evolution of Allorecognition in the Tunicata [PDF]
Biology, 2020 Allorecognition, the ability to distinguish self or kin from unrelated conspecifics, plays several important biological roles in invertebrate animals. Two of these roles include negotiating limited benthic space for colonial invertebrates, and inbreeding
Marie L. Nydam
doaj +4 more sources
Allorecognition by T lymphocytes and allograft rejection [PDF]
Frontiers in Immunology, 2016 Recognition of donor antigens by recipient T cells in secondary lymphoid organs initiates the adaptive inflammatory immune response leading to the rejection of allogeneic transplants.
Gilles Benichou +2 more
doaj +7 more sources
Innate allorecognition in transplantation
The Journal of Heart and Lung Transplantation, 2021 Successful allogeneic transplantation has been made possible by suppressing activation of the adaptive immune system. Current immunosuppressive therapy prevents rejection by targeting T and B cells. Despite this effective treatment, it is the innate immune system, which includes dendritic cells, monocytes, natural killer cells, that is responsible for ...
Khodor I, Abou-Daya +1 more
openaire +3 more sources
TCR cross-reactivity and allorecognition: new insights into the immunogenetics of allorecognition [PDF]
Immunogenetics, 2011 Alloreactive T cells are core mediators of graft rejection and are a potent barrier to transplantation tolerance. It was previously unclear how T cells educated in the recipient thymus could recognize allogeneic HLA molecules. Recently it was shown that both naïve and memory CD4+ and CD8+ T cells are frequently cross-reactive against allogeneic HLA ...
D'Orsogna, L.J. +3 more
openaire +6 more sources
Innate Allorecognition and Memory in Transplantation [PDF]
Frontiers in Immunology, 2020 Over the past few decades, we have witnessed a decline in the rates of acute rejection without significant improvement in chronic rejection. Current treatment strategies principally target the adaptive immune response and not the innate response ...
Daqiang Zhao +10 more
doaj +3 more sources
Uptake of HLA Alloantigens via CD89 and CD206 Does Not Enhance Antigen Presentation by Indirect Allorecognition [PDF]
Journal of Immunology Research, 2016 In organ transplantation, alloantigens are taken up by antigen presenting cells and presented via the indirect pathway to T-cells which in turn can induce allograft rejection.
Eytan Breman +6 more
doaj +2 more sources
What Is Direct Allorecognition? [PDF]
Current Transplantation Reports, 2016 Direct allorecognition is the process by which donor-derived major histocompatibility complex (MHC)-peptide complexes, typically presented by donor-derived 'passenger' dendritic cells, are recognised directly by recipient T cells. In this review, we discuss the two principle theories which have been proposed to explain why individuals possess a high ...
Boardman, Dominic A +4 more
openaire +7 more sources
Pathways of major histocompatibility complex allorecognition [PDF]
Current Opinion in Organ Transplantation, 2008 Here, we review the pathways of allorecognition and their potential relevance to the balance between regulatory and effector responses following transplantation.Transplantation between nonidentical members of the same species elicits an immune response that manifests as graft rejection or persistence.
Afzali, Ben +2 more
openaire +5 more sources
Evolutionary aspects of allorecognition [PDF]
Invertebrate Survival Journal, 2015 LETTER TO EDITOR (no Abstract)
L Ballarin +3 more
doaj +2 more sources
Advanced ScienceIn solid organ transplantation, monocytes and macrophages play a cross‐cutting role in the rejection process, irrespective of the transplanted tissue and the type of rejection. Here, we integrated multiple single‐cell assays (>150,000 cells) with a broad
Alexis Varin +16 more
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