Results 51 to 60 of about 3,437 (186)

Sensitization in Transplantation Assessment of Risk 2025 innate working group: The potential role of innate allorecognition in kidney allograft damage. [PDF]

Am J Transplant
In solid organ transplantation, the alloimmune response is traditionally attributed to the action of alloreactive T cells that recognize mismatched human leukocyte antigens, as well as antibody formation and antibody-mediated rejection.
Thaunat O, Lakkis FG, Kosmoliaptsis V, Schinstock C, Tambur A, Heidt S, Naesens M.   +6 more
europepmc   +2 more sources

Ex Vivo Normothermic Perfusion Induces Donor-Derived Leukocyte Mobilization and Removal Prior to Renal Transplantation

Kidney International Reports, 2016
Ex vivo normothermic perfusion offers an alternative method of organ preservation, allowing donor kidneys to be reanimated and evaluated prior to transplantation.
John P. Stone, Alexandra L. Ball, William R. Critchley, Triin Major, Rebecca J. Edge, Kavit Amin, Marc J. Clancy, James E. Fildes   +7 more
doaj   +1 more source

Membrane attack complexes, endothelial cell activation, and direct allorecognition

Frontiers in Immunology, 2022
Endothelial cells (ECs) form a critical immune interface regulating both the activation and trafficking of alloreactive T cells. In the setting of solid organ transplantation, donor-derived ECs represent sites where alloreactive T cells encounter major ...
Guiyu Song, Guiyu Song, Shaoxun Wang, Shaoxun Wang, Mahsa Nouri Barkestani, Clancy Mullan, Clancy Mullan, Matthew Fan, Bo Jiang, Bo Jiang, Quan Jiang, Xue Li, Xue Li, Dan Jane-wit, Dan Jane-wit, Dan Jane-wit   +15 more
doaj   +1 more source

Clinical Impact of HLA‐DPB1 Permissiveness Models on Acute GVHD and Survival After Unrelated Allogeneic HCT: A Single‐Centre Brazilian Cohort

HLA, Volume 108, Issue 5, November 2026.
ABSTRACT HLA‐DPB1 mismatches are frequent in unrelated allogeneic haematopoietic stem cell transplantation (allo‐HCT), even among donor–recipient pairs matched at conventional HLA loci. Models including T‐cell epitope (TCE), expression and Predicted Indirectly Recognisable HLA Epitopes (PIRCHE) have been proposed to assess HLA‐DPB1 permissiveness.
Matilde Romero, Vinicius Navega Stelet, Mirian Carvalho de Souza, Anna Paula Villela, Gabriela Lemos, Renata Binato, Eliana Abdelhay   +6 more
wiley   +1 more source

Drug induced alloreactivity: A new paradigm for allorecognition

, 2019
Abacavir administration is associated with drug‐induced hypersensitivity reactions in HIV+ individuals expressing the HLA‐B*57:01 allele. However, the immunological effects of abacavir administration in an HLA‐B57 mismatched transplantation setting have ...
D'Orsogna, L.J., Zoet, Y., Chopra, A., Anholts, J., John, M., D'Orsogna, L., Zoet, Y.M., Almeida, C., Witt, C., van Miert, P., Miert, P. van, Anholts, J.D.H., Claas, F., Almeida, C.A.M., Watson, M., Claas, F.H.J.   +15 more
core   +1 more source

Investigation of peptide involvement in T cell allorecognition using recombinant HLA class I multimers

, 2005
Alloreactive T cells are involved in injurious graft rejection and graft-vs-host disease. However, they can also evoke beneficial responses to tumor Ags restricted by foreign MHC molecules.
Barber, L D, Jordan, S, Kester, M, Oosten, L E M, Whitelegg, A M E, Madrigal, J A, van Halteren, A G S, Goulmy, E   +7 more
core   +5 more sources

Corneal Xenotransplantation: Lessons From Allograft Immunobiology and Emerging Translational Strategies

Xenotransplantation, Volume 33, Issue 6, November/December 2026.
ABSTRACT Corneal transplantation is an effective sight‐restoring procedure, yet its global impact remains constrained by limited and uneven access to human donor tissue and by immune‐mediated graft failure, particularly in high‐risk recipients. Xenotransplantation offers a potentially scalable alternative, but successful clinical translation requires ...
Ansu A. John, Ellen H. Koo
wiley   +1 more source

Comprehensive In Vitro Profiling Demonstrates Successful Immune Evasion of Bioengineered Immune‐Shielded Heart Valves

Advanced Healthcare Materials, Volume 15, Issue 39, 23 October 2026.
Living donor heart valves offer superior durability for pediatric patients but trigger immune rejection. Lentiviral delivery of viral immune‐evasion genes US2 and Serpin b9 into donor valve cells and valve tissue suppresses HLA expression, reduces PBMC clustering and cytotoxic killing, and induces transcriptional immune‐tolerance programs, paving the ...
Abraham van Wijk, Leanne Van den Berg, Isa B. M. Velraeds, Valentina Osorio Zuluaga, Emma T. M. Peereboom, Martijn J. W. E. Rabelink, Arnaud Zaldumbide, Rob C. Hoeben, Marie‐Jose T. H. Goumans, Eric Spierings, Carlijn V. C. Bouten, Marijn C. Peters   +11 more
wiley   +1 more source

Stronger Together: Isograft Fusion Accelerates Recovery and May Facilitate Heat‐Evolved Symbiont Transmission in Bleached Adult Corals

Environmental Microbiology Reports, Volume 18, Issue 5, October 2026.
This study investigates whether tissue fusion between adult corals enables transmission of heat‐evolved (HE) symbionts. After ~50 days of fusion to a donor, HE symbionts were detected in chemically bleached Galaxea fascicularis recipients. Fusion also accelerated post‐bleaching recovery.
Bede G. Johnston, Catalina Parra V., Matthew R. Nitschke, Wing Yan Chan, Madeleine J. H. van Oppen   +4 more
wiley   +1 more source

Genetic Background and Allorecognition Phenotype in Hydractinia symbiolongicarpus

, 2011
The Hydractinia allorecognition complex (ARC) was initially identified as a single chromosomal interval using inbred and congenic lines. The production of defined lines necessarily homogenizes genetic background and thus may be expected to obscure the ...
Fadi G Lakkis, Anahid E Powell, Stephen L Dellaporta, Leo W Buss, Maria Moreno, Andrea Gloria-Soria   +5 more
core   +1 more source