Allostery Inhibition of BACE1 by Psychotic and Meroterpenoid Drugs in Alzheimer’s Disease Therapy
Molecules, 2022 In over a century since its discovery, Alzheimer’s disease (AD) has continued to be a global health concern due to its incurable nature and overwhelming increase among older people. In this paper, we give an overview of the efforts of researchers towards
Samuel C. Ugbaja +5 more
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Discovery of an allosteric site in the caspases [PDF]
Proceedings of the National Academy of Sciences, 2004 Allosteric regulation of proteins by conformational change is a primary means of biological control. Traditionally it has been difficult to identify and characterize novel allosteric sites and ligands that freeze these conformational states. We present a site-directed approach using Tethering for trapping inhibitory small molecules at sites away from ...
Jeanne A, Hardy +4 more
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Current Advances in Allosteric Modulation of Muscarinic Receptors
Biomolecules, 2020 Allosteric modulators are ligands that bind to a site on the receptor that is spatially separated from the orthosteric binding site for the endogenous neurotransmitter.
Jan Jakubik, Esam E. El-Fakahany
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Mapping allosteric pathway in NIa‐Pro using computational approach
Quantitative Biology, 2023 Background Computer simulation studies complement in vitro experiments and provide avenue to understand allosteric regulation in the absence of other molecular viewing techniques. Molecular dynamics captures internal motion within the protein and enables
Rashmi Panigrahi, Senthilkumar Kailasam
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Allosteric crosstalk in modular proteins: Function fine-tuning and drug design
Computational and Structural Biotechnology Journal, 2023 Modular proteins are regulatory proteins that carry out more than one function. These proteins upregulate or downregulate a biochemical cascade to establish homeostasis in cells.
Suman Abhishek +4 more
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Aptamer‐Based DNA Allosteric Switch for Regulation of Protein Activity
Advanced ScienceAllostery is a fundamental way to regulate the function of biomolecules playing crucial roles in cell metabolism and proliferation and is deemed the second secret of life.
Hongzhi Sun +4 more
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Ligand Docking Methods to Recognize Allosteric Inhibitors for G-Protein-Coupled Receptors
Bioinformatics and Biology Insights, 2021 G-protein-coupled receptors (GPCRs) are membrane proteins which play an important role in many cellular processes and are excellent drug targets. Despite the existence of several US Food and Drug Administration (FDA)-approved GPCR-targeting drugs, there ...
K Harini +4 more
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Allosteric mechanism for site-specific ubiquitination of FANCD2 [PDF]
Nature Chemical Biology, 2019 DNA-damage repair is implemented by proteins that are coordinated by specialized molecular signals. One such signal in the Fanconi anemia (FA) pathway for the repair of DNA interstrand crosslinks is the site-specific monoubiquitination of FANCD2 and FANCI.
Viduth K. Chaugule +5 more
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Allosteric Lever: Toward a Principle of Specific Allosteric Response
Physical Review XAllostery, the phenomenon by which the perturbation of a molecule at one site alters its behavior at a remote functional site, enables control over biomolecular function.
Maximilian Vossel +2 more
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Probing the Sophisticated Synergistic Allosteric Regulation of Aromatic Amino Acid Biosynthesis in Mycobacterium tuberculosis Using ᴅ-Amino Acids. [PDF]
PLoS ONE, 2016 Chirality plays a major role in recognition and interaction of biologically important molecules. The enzyme 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase (DAH7PS) is the first enzyme of the shikimate pathway, which is responsible for the synthesis
Sebastian Reichau +3 more
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