Structure-guided hydrophobic modulation at the 3-position of <i>Senecio nutans</i>-derived chalcones Drives divergent vascular mechanisms. [PDF]
Front PharmacolPalacios J +5 more
europepmc +1 more source
European Journal of Organic Chemistry, EarlyView.The intramolecular nitrile oxide olefin [3 + 2]‐cycloaddition offers a reliable entry toward 2‐aza‐bicyclo[4.3.0]‐nonanes, a substructure found in several bioactive piperidine alkaloids. The required oxime precursors were prepared in non‐racemic form by Ir‐catalyzed asymmetric allylation and ring‐closing metathesis.
Alicia Köcher +5 more
wiley +1 more source
Onion (<i>Allium cepa L</i>.) Organosulfur Compounds: From Traditional Use to Modern Pharmacological Insights. [PDF]
Food Sci NutrTang Y, Lv, Tao Y.
europepmc +1 more source
Gold(I)‐Mediated Reactivity of Allenes With Mesoionic Nucleophiles: A Computational Exploration
European Journal of Organic Chemistry, EarlyView.The regioselective gold(I)‐mediated reactivity of allenes with mesoionic nucleophiles has been evaluated through computational analysis of the mechanisms involved. Instead of typical (3 + 2) pathways, sydnones and münchnones favour the formal (3 + 3) cyclizations affording substituted dihydropyridines.
Eduardo Garcia‐Padilla, Feliu Maseras
wiley +1 more source
Remarkable Formation of Indene Derivatives Upon Friedel–Crafts Acylation Reactions
European Journal of Organic Chemistry, EarlyView.This shows indene derivatives. Under the reaction conditions of a Friedel–Crafts acylation, alkyl benzenes underwent an unprecedented cyclopentannulation furnishing indene derivatives. Alkylbenzene derivatives react with two equivalents of pivaloyl chloride (PivCl) in the presence of aluminum trichloride under formation of indene derivatives with up to
Leah Bantel +3 more
wiley +1 more source
Classification of industrial chemicals for respiratory chemosensory irritation using the TRPV1-expressing neuronal SH-SY5Y cell model and machine learning. [PDF]
Arch ToxicolHinojosa M +3 more
europepmc +1 more source
European Journal of Organic Chemistry, EarlyView.Chiral tri‐ and pentahydroxy spirocyclopentane‐indolizidines were synthesized using lithium diisopropylamide “LDA” promoted diallylation and tetrahydrofuran “THF” ring‐opening in a one‐pot procedure as a key step. The sequence leading to the targeted hydroxy‐spiroindolizidines was achieved by cis‐dihydroxylation followed by reduction of the enamine and
Paula Fraňová +6 more
wiley +1 more source
Brønsted Base-Catalyzed Aminoxylation of Benzylic and Allylic Compounds with TEMPO. [PDF]
Org LettKondoh A, Terada M.
europepmc +1 more source
European Journal of Organic Chemistry, EarlyView.Effective synthesis of 3‐substituted isoindolinones is possible through novel cascade reactions of alkyl arylacetates with 2‐cyanobenzaldehydes under mild, basic conditions. Herein we report the use of alkyl arylacetates as pro‐nucleophiles in cascade reactions with 2‐cyanobenzaldehydes leading to the formation of novel 3‐substituted isoindolinones, a ...
Antonia Di Mola +4 more
wiley +1 more source
Coumarin compounds as fungicidal agents against powdery mildew and rust in cereals. [PDF]
Sci RepRząd K +4 more
europepmc +1 more source