Results 81 to 90 of about 5,366 (218)

Pharmacokinetic Comparison in Rats of Six Bioactive Compounds between Decoction and its Parent Herbal Medicines

Natural Product Communications, 2010
Da-Cheng-Qi decoction (DCQD) is a purgative compound prescription used in China and East Asia. In this paper, pharmacokinetic differences of six major active components (rhein, emodin, aloe-emodin, magnolol, naringenin and hesperetin) between DCQD and ...
Fengguo Xu, Ying Liu, Haijuan Dong, Rui Song, Zunjian Zhang   +4 more
doaj   +1 more source

Medicinal Plants and Lead Phytomolecules as Immunomodulators: An Updated Review

BioMed Research International, Volume 2026, Issue 1, 2026.
All therapeutic interventions aimed at modulating the immune response to pathogens, self‐antigens, carcinogens, or xenogeneic antigens are referred to as immunomodulation, which either prevents hyperactivation or restores the appropriate response of the immune system.
Gurdeep Singh, Vikas Sharma, Blessing Nnenna Udeh, Baisakhi Banerjee   +3 more
wiley   +1 more source

Lipid storage and autophagy in melanoma cancer cells [PDF]

, 2017
Cancer stem cells (CSC) represent a key cellular subpopulation controlling biological features such as cancer progression in all cancer types. By using melanospheres established from human melanoma patients, we compared less differentiated melanosphere ...
Cordella, Martina, Eramo, A, Facchiano, A, Facchiano, F, Filippini, Antonio, Giampietri, Claudia, Petrungaro, Simonetta, Tabolacci, C, Tomaipitinca, Luana, Ziparo, Elio   +9 more
core   +2 more sources

Achieving Steroid‐Sparing Remission in Refractory Pyoderma Gangrenosum With an Integrative Meta‐Therapeutic System Based on Traditionally Engineered Nanomercury Sulfide: A Case Series

Case Reports in Dermatological Medicine, Volume 2026, Issue 1, 2026.
The management of pyoderma gangrenosum (PG) remains a formidable clinical challenge due to its complex, multipathway immunopathogenesis. Although conventional steroid therapy and advanced biologic agents have improved outcomes, a substantial proportion of patients, particularly those with severe, progressive ulceration, exhibit treatment‐refractory ...
Magesh Kirubakaran J. P., Pooja Shrivastav, Sangeetha R., Surya Kumar K., Ayumi Saito, Sakthivel T., Harleen Khatra   +6 more
wiley   +1 more source

Human intestinal Bacteroides spp. RHEIN-I and RHEIN-II capable of transforming rhein to rheinanthrone, induce rhein-dependent diarrhea in rats [PDF]

, 2001
Two rhein-metabolizing bacteria were isolated from human feces. The biochemical and morphological characteristics of both isolates were typical of Bacteroides spp. and named strains RHEIN-I and RHEIN-II, respectively. Rhein was effectively metabolized to
Akao Teruaki, Hattori Masao, MESELHY Ragab, Nishimoto Eri   +3 more
core   +1 more source

Forced degradation studies of aloe emodin and emodin by HPTLC

Indian Journal of Pharmaceutical Sciences, 2015
Anthraquinones are natural phenolic compounds, which are reported to act as anti-aging, anti-inflammatory, antioxidant, anti-cancer, laxative and antitumor agents. They are abudant in plants like candle bush, aloes, cascara bark and rhubarb. The present work was to observe the effect of different forced degradation conditions by high-performance thin ...
Sindhu, Narayanan, Aruna P, Jadhav, V J, Kadam   +2 more
openaire   +3 more sources

Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral Ischemia

Molecules, 2019
(1) Background: Rhubarb anthraquinones—a class of components with neuroprotective function—can be used to alleviate cerebral ischemia reperfusion injury. (2) Methods: The three pharmacodynamic indicators are neurological function score, brain
Rong-Rong Li, Xue-Fang Liu, Su-Xiang Feng, Sheng-Nan Shu, Pei-Yang Wang, Na Zhang, Jian-Sheng Li, Ling-Bo Qu   +7 more
doaj   +1 more source

Healthy Drink Mixtures With Tropical Fruits, Cashew (Anacardium occidentale), Acerola (Malpighia emarginata), and Aloe Vera (Aloe barbadensis Miller)

International Journal of Food Science, Volume 2026, Issue 1, 2026.
Tropical fruits are sources of bioactive compounds with potential health benefits. The objective of this study was to optimize functional beverage formulations using Aloe vera gel (Aloe barbadensis Miller), clarified cashew juice (Anacardium occidentale), and acerola pulp (Malpighia emarginata), integrating mixture design optimization with kinetic ...
Jorge Osorio Martinez, Maria Guerra Solano, Rafael Arango Barbas, Guillermo Arrazola Paternina, Navneet Kumar   +4 more
wiley   +1 more source

Growth and apoptosis pathways in human cutaneous melanoma: in vitro and in vivo studies by using biological and proteomics approaches [PDF]

, 2013
Purpose. Melanoma is the most aggressive cutaneous cancer without effective treatment. Diagnosis is achieved very often too late and prognosis is poor.
ROSSI, STEFANIA
core  

Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2 [PDF]

Carcinogenesis, 2012
Phosphatidylinositol 3-kinase (PI3-K) amplification and phosphatase and tensin homolog (PTEN) deletion-caused Akt activation contribute to the development of prostate cancer. Mammalian target of rapamycin complex 2 (mTORC2) is a kinase complex comprised of mTOR, Rictor, mSin1, mLST8/GβL and PRR5 and functions in the phosphorylation of Akt at Ser473 ...
Kangdong, Liu, Chanmi, Park, Shengqing, Li, Ki Won, Lee, Haidan, Liu, Long, He, Nak Kyun, Soung, Jong Seog, Ahn, Ann M, Bode, Ziming, Dong, Bo Yeon, Kim, Zigang, Dong   +11 more
openaire   +2 more sources