Results 61 to 70 of about 24,353 (199)

A Plant Photoregulator‐Inspired S‐Type Heterojunction System for Diabetic Keratopathy via Tri‐Modal Light‐Driven Immunometabolic Reprogramming, Tissue Repair, and Antibacterial Activity

Advanced Science, Volume 13, Issue 53, 24 September 2026.
To address the multifaceted imbalance in diabetic keratopathy, a light‐responsive biomimetic platform (WCNx‐Rh2) is developed and integrates glucose degradation, immune modulation, and antibacterial defense through a designed heterojunction and screened immunomodulator. WCNx‐Rh2 reduces AGEs/ROS and inflammatory signaling, reprogramming dendritic cells
Mengzhen Zhao, Zhibin Zhou, Yuxuan Wei, Xiangfan Huang, Zhiyong Zhou, Jiaheng Chen, Haoxin Cheng, Xiaotian Hu, Xiaolei Wang   +8 more
wiley   +1 more source

Microglia and neuroinflammation: An in‐depth analysis from functional diversity to disease mechanisms

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
1. Microglial functions arise from dynamic, context‐dependent programs rather than fixed M1/M2 phenotypes. 2. Inflammatory, interferon‐responsive, phagocytic/lipid‐metabolic and repair‐associated programs coexist across disease stages and brain regions. 3.
Jie Chen, Wangzheqi Zhang, Lizhou Song, Yan Liao, Haoling Zhang, Yiyang Xia, Derong Cui   +6 more
wiley   +1 more source

Absence of genotoxicity of purified Aloe vera whole leaf dry juice as assessed by an in vitro mouse lymphoma tk assay and an in vivo comet assay in male F344 rats

Toxicology Reports, 2021
Hydroxyanthracene derivatives (HAD) are naturally present in the latex layer of Aloe vera leaf, predominantly as aloins A, B and aloe-emodin. HAD are typically removed from commercial ingestible aloe products through activated charcoal filtration ...
Jiang Hu, Mel Lloyd, Cheryl Hobbs, Peter Cox, Keith Burke, Gareth Pearce, Michael A. Streicker, Quanyin Gao, Vasilios Frankos   +8 more
doaj   +1 more source

Natural Photosensitizers in Cancer Therapy: A Chemo‐Biodiversity Perspective on Light‐Activated Natural Compounds

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
Natural photosensitizers, shaped by chemo‐biodiversity and evolution, offer diverse photoactive scaffolds for PDT. This review highlights their structure–activity relationships, photophysical properties, and nanotechnology‐based strategies to enhance efficacy, while addressing translational challenges and demonstrating how nature's molecular diversity ...
Isaac Baidoo, Heidi Abrahamse, Blassan P. George   +2 more
wiley   +1 more source

Recent Developments in Chemical Synthesis and Biological Activities of Aloe-Emodin Derivatives

Organics
Aloe-emodin is an anthraquinone with a wide range of medicinal applications, including anti-angiogenic, anticancer, antimicrobial, antiviral, anti-inflammatory, and antioxidant activities.
Jeltzlin Semerel, Nigel John, Pedro Fardim, Wim Dehaen   +3 more
doaj   +1 more source

Barbaloin Attenuates Cisplatin‐Induced Hippocampal Neurotoxicity by Suppressing Oxidative Stress, Neuroinflammation, and Apoptosis: In Vivo and In Silico Evidence

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
Important Aloe vera phytonutrient, barbaloin, inhibits the neurotoxic effects of cisplatin on hippocampus, which involves reducing oxidative stress, neuroinflammation, and apoptosis, thereby restoring the balance of neurotransmitters and cognition. The generated docking structures with 100‐ns molecular dynamics simulations show stable energy‐minimized ...
Rahamat Unissa Syed, Rihab Akasha, Nancy Mohammad Elafandy, Sally Hassan Abobaker, Afrah Nashmi Al‐Shammari, Lama Abdullah Altwalah, Rawabi Mohammed Menwer Aldafeeri, Amira Ibrahim Mohammed Ahmed Alfaki, Mohd Sajjad Ahmad Khan, Ashgan A. Ahmed   +9 more
wiley   +1 more source

Aloe-emodin is an interferon-inducing agent with antiviral activity against Japanese encephalitis virus and enterovirus 71 [PDF]

, 2010
[[abstract]]In this study, aloe-emodin was identified as a potential interferon (IFN)-inducer by screening compounds from Chinese herbal medicine. Aloe-emodin showed low cytotoxicity to human HL-CZ promonocyte cells and TE-671 medulloblastoma cells and ...
Lin, CW (Lin, Cheng-Wen); Wu, CF (Wu, Chia-Fang); Hsiao, NW (Hsiao, Nai-Wan); Chang, CY (Chang, Ching-Yao); Li, SW (Li, Shih-Wein); Wan, L (Wan, Lei); Lin, YJ (Lin, Ying-Ju); Lin, WY (Lin, Wei-Yong)
core  

Avaliação dos efeitos de aloe-emodin em células uroteliais imortalizadas e neoplásicas cultivadas in vitro

, 2013
Aloe vera (Aloe barbadensis Miller), popularly known in Brazil as babosa, has a long history of use as medicinal plant for different therapeutic purposes.
Naves, Marina Araújo
core   +3 more sources

The Role of Inflammation and Immunity in Cardiovascular Disease: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 8, August 2026.
Inflammation in cardiovascular disease is a dynamic and context‐dependent network rather than a secondary response to injury. Mitochondrial danger signaling links metabolic stress to immune activation through TLR priming, NLRP3 inflammasome amplification, cGAS–STING signaling, and immunometabolic gating, providing a basis for more precise therapeutic ...
Jiaxiang Rong, Zhen Wang, Xiaoxiao Lin, Ziwen Lei, Qianqian Huang, Hang Liu, Fei Luan, Junbo Zou, Yajun Shi   +8 more
wiley   +1 more source

Safety of hydroxyanthracene derivatives for use in food

EFSA Journal, 2018
The Panel on Food Additives and Nutrient Sources added to Food (ANS) was asked to deliver a scientific opinion on the safety of hydroxyanthracene derivatives and to provide advice on a daily intake that does not give rise to concerns about harmful ...
EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS), Maged Younes, Peter Aggett, Fernando Aguilar, Riccardo Crebelli, Metka Filipič, Maria Jose Frutos, Pierre Galtier, David Gott, Ursula Gundert‐Remy, Gunter Georg Kuhnle, Claude Lambré, Jean‐Charles Leblanc, Inger Therese Lillegaard, Peter Moldeus, Alicja Mortensen, Agneta Oskarsson, Ivan Stankovic, Ine Waalkens‐Berendsen, Rudolf Antonius Woutersen, Raul J Andrade, Cristina Fortes, Pasquale Mosesso, Patrizia Restani, Fabiola Pizzo, Camilla Smeraldi, Adamantia Papaioannou, Matthew Wright   +27 more
doaj   +1 more source