Results 181 to 190 of about 7,225 (307)

Efficacy and safety of fruquintinib combined with albumin‐bound paclitaxel as second‐line therapy for advanced gastric cancer following failure of PD‐1 inhibitor‐containing treatment (TACTIC GC‐01): A phase II single‐arm study

International Journal of Cancer, Volume 158, Issue 9, Page 2219-2228, 1 May 2026.
What's new? Anti‐angiogenic drugs have shown promising efficacy as a second‐line treatment for advanced gastric cancer. However, it remains unclear how alterations in the tumor microenvironment following first‐line immunotherapy may impact tumor angiogenesis and influence subsequent therapeutic outcomes. This single‐arm study prospectively explored the
Xiaoting Ma, Kai Ou, Xiu Liu, Biyang Cao, Wenwei Yang, Jingyu Lu, Letian Zhang, Qi Wang, Lizhen Gao, Zhichao Jiang, Yongkun Sun, Lin Yang   +11 more
wiley   +1 more source

Complete genome sequencing of Bacillus velezensis Jin12 revealed its great ability for starch degradation in flue-cured tobacco leaves. [PDF]

BMC Microbiol
Yang Y, Yang M, Zhang Y, Yang B, Miao C, Liang T, Xu Q, Hu L, Hu Z.   +8 more
europepmc   +1 more source

Gap Analysis of Metabolic Conversions of Off‐Flavors and Antinutrients in Plant‐Based Substrates

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT To drastically reduce the carbon footprint of the food production chain, a major shift towards alternatives to conventional meat and dairy products is required. The use of plant‐based proteins is a promising route, but it also comes with challenges: Plant‐based proteins often contain antinutritional factors and off‐flavors, which can ...
Robin I. Kuijpers, Isabel O. de Moya Clark, Tomás Cavaco, Vivian Nemanič, Beatrice Tagliabue, Ainhoa Abad Valero, Wiebe M. Wennekers, Mengqiu Zhang, Koen Van Zwet, Sanne Abeln, Sofia Moco, Caroline E. Paul, Halima Mouhib, Richard A. Notebaart, Eddy J. Smid, Bas Teusink, Herwig Bachmann   +16 more
wiley   +1 more source

Heterologous Expression and Biochemical Characterization of a New α-Amylase from <i>Nocardiopsis aegyptia</i> HDN19-252 of Antarctic Animal Origin. [PDF]

Mar Drugs
Liu F, Zheng X, Liao W, Ren X, Ma C, Zhang G, Che Q, Zhu T, Wang W, Zhang T, Han F, Li D.   +11 more
europepmc   +1 more source

Inhibition of Calcium‐Dependent Lipid Droplets Relocation of ACSL4‐PKCβ‐ALOX15 Complex Alleviates Ferroptosis and Acute Pancreatitis

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This study identifies L‐type calcium channel blockers as novel ferroptosis inhibitors. It reveals that PKCβ, activated in calcium dependent manner, phosphorylates and activates ACSL4 and ALOX15, relocating them to lipid droplets to promote lethal lipid peroxidation and ferroptosis.
Guoyuan Hou, Jing Luan, Xiaoyong Xu, Jianhua Qin, Shuang Ma, Jiyuan He, Na Sun, Wei Zhang, Minghui Gao   +8 more
wiley   +1 more source

Peptides from Animal Venoms: A Promising Frontier in Diabetes Therapy via Multi-Target Mechanisms. [PDF]

Pharmaceuticals (Basel)
de Almeida JOCS, Comerma-Steffensen SG, de Souza de Almeida Leite JR, Simonsen U, Arcanjo DDR.   +4 more
europepmc   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

HPTLC based screening method for the evaluation of α-amylase inhibitory activity in edible flowers. [PDF]

Sci Rep
Litewski S, Mróz M, Kusznierewicz B.
europepmc   +1 more source

Inhibitory Effect of Lidocaine on Duodenal Peristalsis During Endoscopic Retrograde Cholangiopancreatography: A Multicenter, Randomized Controlled Trial (With Video)

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Objectives Conventional antispasmodics used during endoscopic retrograde cholangiopancreatography (ERCP), such as hyoscine butylbromide and glucagon, are often contraindicated in elderly patients with comorbidities. This trial aimed to assess the efficacy of lidocaine for inhibiting duodenal peristalsis during ERCP.
Masato Suzuki, Yusuke Sekino, Kunihiro Hosono, Yusuke Kurita, Hiroki Uechi, Kento Kuzuu, Shiori Uchiyama, Kenichi Kawana, Hajime Nagase, Kensuke Kubota, Masato Yoneda, Atsushi Nakajima   +11 more
wiley   +1 more source

Expression of pancreatic α-amylase and growth related genes during larval ontogeny in striped murrel (Channa striata). [PDF]

Sci Rep
Kumari R, Srivastava PP, Mohanta KN, Das P, Kumar R, Sharma P, Sahoo L, Rajesh M, Siddaiah GM.   +8 more
europepmc   +1 more source