Results 241 to 250 of about 26,643 (286)

Alpha lipoic acid

The Netherlands Journal of Medicine, 2010
Background: Neuropathic pain is difficult to treat. We identified those studies in the literature in which the effectiveness of alpha lipoic acid as a treatment for neuropathic pain was evaluated.Methods: Systematic literature review. The databases MEDLINE and EMBASE were searched using the keywords "lipoic acid", "thioctic acid", "diabet*", and the ...
Mijnhout, G. S., Alkhalaf, A., Kleefstra, N., Bibo, H. J. G.   +3 more
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Alpha-lipoic acid as a biological antioxidant

Free Radical Biology and Medicine, 1995
alpha-Lipoic acid, which plays an essential role in mitochondrial dehydrogenase reactions, has recently gained considerable attention as an antioxidant. Lipoate, or its reduced form, dihydrolipoate, reacts with reactive oxygen species such as superoxide radicals, hydroxyl radicals, hypochlorous acid, peroxyl radicals, and singlet oxygen.
L, Packer, E H, Witt, H J, Tritschler
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ALSUntangled #79: alpha-lipoic acid

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Alpha-lipoic acid (ALA) is a naturally occurring fatty acid. It serves as an essential cofactor for enzymatic reactions in mitochondrial energy production, is a potent antioxidant and has anti-inflammatory effects, which are plausible mechanisms in slowing ALS progression.
Alaina Giacobbe, James Hiana, Olivia Wang, Michael Benatar, Paul Wicks, Javier Mascias Cadavid, Sartaj Jhooty, Christopher McDermott, Gary Pattee, Tulio Bertorini, Terry Heiman-Patterson, Dylan Ratner, Paul Barkhaus, Gregory Carter, Carlayne Jackson, Keelie Denson, Andrew Brown, Carmel Armon, Yuyao Sun, Andre Nguyen, Richard Bedlack, Xiaoyan Li   +21 more
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Alpha-lipoic acid attenuates lipopolysaccharide-induced kidney injury

Clinical and Experimental Nephrology, 2014
Kidney is one of the major target organs in sepsis, while effective prevention of septic acute kidney injury has not yet been established. α-Lipoic acid (LA) has been known to exert beneficial effects against lipopolysaccharide (LPS)-induced damages in various organs such as heart, lung, and liver.
Sang Heon, Suh, Ko Eun, Lee, In Jin, Kim, Ok, Kim, Chang Seong, Kim, Joon Seok, Choi, Hoon-In, Choi, Eun Hui, Bae, Seong Kwon, Ma, Jong Un, Lee, Soo Wan, Kim   +10 more
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Alpha-Lipoic Acid May Improve Symptomatic Diabetic Polyneuropathy

The Neurologist, 2007
In patients with symptomatic diabetic polyneuropathy, is oral alpha-lipoic acid (ALA) effective in improving neuropathic symptoms compared with placebo?The question was addressed with a structured evidence-based clinical neurologic practice review via videoconferencing between 3 academic institutions.
Junger, Tang, Dean M, Wingerchuk, Brian A, Crum, Devon I, Rubin, Bart M, Demaerschalk   +4 more
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Alpha-Lipoic Acid Reduces Ethanol Self-Administration in Rats

Alcoholism: Clinical and Experimental Research, 2013
The main system of central ethanol (EtOH) oxidation is mediated by the enzyme catalase. By reacting with H2 O2 , brain catalase forms compound I (the catalase-H2 O2 system), which is able to oxidize EtOH to acetaldehyde (ACD) in the brain. We have previously shown that ACD regulates EtOH motivational properties and possesses reinforcing effects by ...
PEANA, Alessandra Tiziana, Muggironi G, Fois GR, DIANA, Marco   +3 more
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Alpha lipoic acid intoxication, treatment and outcome

Clinical Toxicology, 2013
Dear Editor,Alpha lipoic acid (ALA) is a cofactor found in a number of multienzyme complexes. Lipoic acid and its reduced form, dihydrolipoic acid, are antioxidants in vivo.
Isguder, Rana, Unal, Nurettin, Karaarslan, Utku, Bag, Ozlem, Kisla, Miray, Agin, Hasan   +5 more
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Decomposition of alpha-lipoic acid derivatives by photoirradiation-formation of dihydrolipoic acid from alpha-lipoic acid-.

Biochemistry and molecular biology international, 1997
Due to its strained five-membered ring, alpha-lipoic acid (LA) has an absorption band around 330 nm, which is used to quantify its concentration. In order to obtain information for the homolytic rupture of the S-S bond and the formation of dihydrolipoic acid (DHLA), the photochemical reaction of lipoic acid was examined in the presence or absence of ...
S, Matsugo, D, Han, H J, Tritschler, L, Packer   +3 more
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Alpha lipoic acid: a novel treatment for depression

Medical Hypotheses, 2000
Insulin resistance has been associated with people diagnosed with depression. Conversely, it has also been documented that diabetics have an increased risk of depression. Evidence suggests that insulin activity plays a role in serotonergic activity by increasing the influx of tryptophan into the brain. This increased influx of tryptophan has been shown
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Alpha-lipoic acid supplementation and diabetes.

Nutrition reviews, 2009
Diabetes is a common metabolic disorder that is usually accompanied by increased production of reactive oxygen species or by impaired antioxidant defenses. Importantly, oxidative stress is particularly relevant to the risk of cardiovascular disease.
Uma, Singh, Ishwarlal, Jialal
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