Results 241 to 250 of about 27,057 (295)
Author Correction: Taurine, alpha lipoic acid and vitamin B6 ameliorate the reduced developmental competence of immature mouse oocytes exposed to methylglyoxal. [PDF]
Sci RepMokhtari S +5 more
europepmc +1 more source
Alpha lipoic acid in obstetrics and gynecology
Gynecological Endocrinology, 2018 Alpha-Lipoic acid (ALA) is a natural antioxidant synthetized by plants and animals, identified as a catalytic agent for oxidative decarboxylation of pyruvate and α-ketoglutarate. In this review, we analyzed the action of ALA in gynecology and obstetrics focusing in particular on neuropathic pain and antioxidant and anti-inflammatory action.
Chiara Di Tucci +2 more
exaly +4 more sources
Dihydro-alpha-lipoic acid has more potent cytotoxicity than alpha-lipoic acid
In Vitro Cellular and Developmental Biology - Animal, 2009 Alpha-lipoic acid has been shown to possess cancer-cell-killing activity via activation of the apoptosis pathway. In this study, the cytotoxic activities of alpha-lipoic and dihydro-alpha-lipoic acid were compared in HL-60 cells. The cell-killing activity of dihydro-alpha-lipoic acid was higher than that of alpha-lipoic acid.
Masao Yamasaki +2 more
exaly +4 more sources
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Alpha lipoic acid for dementia
Cochrane Database of Systematic Reviews, 2002Oxidative processes have been implicated in the pathogenesis of neurodegenerative dementias including Alzheimer's disease. Protecting the central nervous system against these damaging mechanisms may be a useful therapeutic approach. Alpha lipoic acid (ALA) is an endogenous antioxidant that interrupts cellular oxidative processes in both its oxidized ...
Anthony Klugman +3 more
openaire +2 more sources
Alpha lipoic acid intoxicatıon: An adult
The American Journal of Emergency Medicine, 2018Alpha lipoic acid (ALA) is a potent antioxidant used to treat a variety of disorders. Although ALA is considered a very safe supplement and intoxication is very rare, acute high-dose ingestions can cause mortality. In this report, we discuss a very rare case of ALA intoxication to increase awareness of this issue.A 22-year-old female was referred to ...
ÖZTURAN, İBRAHİM ULAŞ +2 more
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Alpha-lipoic acid as a biological antioxidant
Free Radical Biology and Medicine, 1995alpha-Lipoic acid, which plays an essential role in mitochondrial dehydrogenase reactions, has recently gained considerable attention as an antioxidant. Lipoate, or its reduced form, dihydrolipoate, reacts with reactive oxygen species such as superoxide radicals, hydroxyl radicals, hypochlorous acid, peroxyl radicals, and singlet oxygen.
L, Packer, E H, Witt, H J, Tritschler
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Arbor Clinical Nutrition Updates, 2006
In a nutshellALA is a powerful antioxidant, both water and lipid soluble, that can also regenerate other antioxidants.A range of ‘antioxidant’ and other clinical indications (such as chelating toxic metals) have been tested in small, open trials and/or animal studies.
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In a nutshellALA is a powerful antioxidant, both water and lipid soluble, that can also regenerate other antioxidants.A range of ‘antioxidant’ and other clinical indications (such as chelating toxic metals) have been tested in small, open trials and/or animal studies.
openaire +1 more source
ALSUntangled #79: alpha-lipoic acid
Amyotrophic Lateral Sclerosis and Frontotemporal DegenerationAlpha-lipoic acid (ALA) is a naturally occurring fatty acid. It serves as an essential cofactor for enzymatic reactions in mitochondrial energy production, is a potent antioxidant and has anti-inflammatory effects, which are plausible mechanisms in slowing ALS progression.
Alaina Giacobbe +21 more
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The effects of alpha-lipoic acid on diabetic myopathy
Journal of Endocrinological Investigation, 2017Increased oxidative stress and impaired antioxidant defense are important mechanisms in the pathogenesis of diabetic myopathy. Since diabetes mellitus type 1 decreases muscle regeneration capacity the present study was designed to determine the influence of alpha-lipoic acid (ALA), a potent biological antioxidant, on the process of regeneration of ...
Jurišić Eržen, Dubravka +5 more
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The Netherlands Journal of Medicine, 2010
Background: Neuropathic pain is difficult to treat. We identified those studies in the literature in which the effectiveness of alpha lipoic acid as a treatment for neuropathic pain was evaluated.Methods: Systematic literature review. The databases MEDLINE and EMBASE were searched using the keywords "lipoic acid", "thioctic acid", "diabet*", and the ...
Mijnhout, G. S. +3 more
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Background: Neuropathic pain is difficult to treat. We identified those studies in the literature in which the effectiveness of alpha lipoic acid as a treatment for neuropathic pain was evaluated.Methods: Systematic literature review. The databases MEDLINE and EMBASE were searched using the keywords "lipoic acid", "thioctic acid", "diabet*", and the ...
Mijnhout, G. S. +3 more
openaire +1 more source