Mitochondrial lipoylation integrates age-associated decline in brown fat thermogenesis. [PDF]
, 2019 Thermogenesis in brown adipose tissue (BAT) declines with age; however, what regulates this process remains poorly understood. Here, we identify mitochondria lipoylation as a previously unappreciated molecular hallmark of aged BAT in mice.
Chang, Chih-Hsiang +9 more
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In Vivo Anti-inflammatory Activity of Lipoic Acid Derivatives in Mice [PDF]
, 2013 Background: In mammals lipoic acid (LA) and its reduced form dihydrolipoic acid (DHLA) function as cofactors for multienzymatic complexes catalyzing the decarboxylation of α-ketoacids.
Anna Bilska-Wilkosz +10 more
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Oral plus vaginal alpha-lipoic acid in women at risk for preterm delivery [PDF]
, 2018 Objective: The etiology of preterm labor is multifactorial. An inflammatory response is always involved with the activation of NF-kB that determines synthesis and release of inflammatory molecules, implicated in fetal membrane activation, cervical ...
Giallombardo V. +4 more
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Dihydrolipoic acid reduces cytochrome b561 proteins. [PDF]
, 2013 Cytochrome b561 (Cyt-b561) proteins constitute a family of trans-membrane proteins that are present in a wide variety of organisms. Two of their characteristic properties are the reducibility by ascorbate (ASC) and the presence of two distinct b-type ...
A Bast +61 more
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Asian Pacific Journal of ReproductionObjective: To investigate the protective effect of alpha-lipoic acid on lead-induced Sertoli cell injury and its potential molecular mechanisms using primary Sertoli cells from rooster testes. Methods: Primary Sertoli cells from 6-week-old rooster testes
Junrong Li +3 more
doaj +1 more source
alpha-lipoic acid suppresses 6-hydroxydoparnine-induced ROS generation and apoptosis through the stimulation of glutathione synthesis but not by the expression of heme oxygenase-1 [PDF]
, 2008 We previously reported that the generation of reactive oxygen species (ROS) is the initial event in cell death induced by 6-hydroxydopamine (6-OHDA), an experimental model of Parkinsonism.
Akagi, Reiko +9 more
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Alpha-lipoic acid drugs in the treatment of diabetic neuropathy
Медицинский совет, 2014 Diabetic neuropathy is the most common complication of diabetes mellitus. Among the large number of drugs used as symptomatic therapy to reduce its manifestations, alpha-lipoic acid medications are specific for providing pathogenic effect on many ...
L. Y. Morgunov
doaj +1 more source
Combination of inositol and alpha lipoic acid in metabolic syndrome-affected women: a randomized placebo-controlled trial [PDF]
, 2013 Inositol has been reported to improve insulin sensitivity since it works as a second messenger achieving insulin-like effects on metabolic enzymes. The aim of this study was to evaluate the inositol and alpha lipoic acid combination effectiveness on ...
Botti, Gerardo +15 more
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The use of rosuvastatin and alpha lipoic acid in patients with unstable angina
Acta Medica Leopoliensia, 2017 Aim. To investigate the blood lipid profile, indices of functional condition of the liver in patients with unstable angina in the treatment of statins in combination with alpha lipoic acid. Material and Methods.
E.H. Zaremba +3 more
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The Effect of Alpha Lipoic Acid in Preventing Atherosclerosis Lesion on the Abdominal Aorta of Diabetes Mellitus Type 2 Rats [PDF]
, 2017 Various studies have studied the clinical use of alpha-lipoic acid (ALA) for treating diabetic complications. The protective effect of lipoic acid in atherosclerosis induced by diabetes mellitus type 2 (DM type 2) still needs further ...
ismawati, I. (Ismawati) +1 more
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