Estimation of pharmacokinetic parameters of alpha-lipoic acid in the chicks model
Baghdad Journal of Biochemistry and Applied Biological Sciences, 2022 Background and objective: Alpha-lipoic acid is a drug used to treat diabetic neuropathy, and it has other uses as a dietary supplement. The target of the study was to investigate the concentration of therapeutic doses of Alpha-lipoic acid in the blood ...
Marwa R. Abdulghani, Ahmed S. Naser
doaj +1 more source
Experimental Study of the Possible Protective Effect of Alpha-Lipoic Acid on Paracetamol induced Oxidative Stress and Hepatic Toxicity in albino rats [PDF]
Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 2021 Background: Paracetamol, is the most widely used over-the-counter analgesic and antipyretic medication in the world, which has minimal adverse effects at therapeutic dosages. But in high doses causes hepatic damage and oxidative stress.
Maha Hilal +4 more
doaj +1 more source
Activity of serum paraoxonase 1, lipid profile and atherogenic indexes in diabetic induced rats treated with alpha lipoic acid [PDF]
Journal of Nephropathology, 2018 Background: Paraoxonase 1 (PON1) is an enzyme attached to high density lipoprotein (HDL-C) which has antioxidant and anti-atherogenic activities. Objectives: In this study, we investigated the effects of alpha lipoic acid on PON1 activity, lipid profile ...
Parisa Jamor +3 more
doaj +1 more source
Качественная клиническая практика, 2021 Rational pharmacotherapy in the Program of Preferential Medicinal Providing can be implemented subject to high-quality information support from healthcare professionals.
E. V. Eliseeva +4 more
doaj +1 more source
Role of Alpha Lipoic Acid on Cyclophosphamide Induced Cardiotoxicity in Adult Male Albino Rat: Histological Study [PDF]
The Egyptian Journal of Histology, 2019 Background: Cyclophosphamide is a chemotherapeutic agent used for treatment of leukemia, lymphoma and myeloma. Several studies reported wide range of cyclophosphamide induced cardiotoxicity in cancerous patients.
manar bashandy, omyma zedan
doaj +1 more source
Knockout studies reveal an important role of plasmodium lipoic acid protein ligase a1 for asexual blood stage parasite survival [PDF]
, 2009 Lipoic acid (LA) is a dithiol-containing cofactor that is essential for the function of a-keto acid dehydrogenase complexes. LA acts as a reversible acyl group acceptor and 'swinging arm' during acyl-coenzyme A formation.
Sylke Müller +9 more
core +2 more sources
Alpha-Lipoic Acid Is an Effective Nutritive Antioxidant for Healthy Adult Dogs
Animals, 2021 This study was designed to determine the effect of alpha-lipoic acid on the glutathione status in healthy adult dogs. Following a 15 month baseline period during which dogs were fed a food containing no alpha-lipoic acid, dogs were randomly allocated ...
Reshma M. Anthony +4 more
doaj +1 more source
Alpha-lipoic acid – a health-promoting compound [PDF]
, 2021 Nutrition is one of the most important factors influencing health status and physical performance. Alpha-lipoic acid is a potent antioxidant. It regulates mitochondrial metabolism and protects cells against oxidative stress.
Mirowski, Adam
core
Retracted: Alpha-lipoic acid supplementation and diabetes [PDF]
Nutrition Reviews, 2008 Diabetes is a common metabolic disorder that is usually accompanied by increased production of reactive oxygen species or by impaired antioxidant defenses. Importantly, oxidative stress is particularly relevant to the risk of cardiovascular disease.
Uma, Singh, Ishwarlal, Jialal
openaire +2 more sources
Encapsulation of α-Lipoic Acid in Halloysite Nanotubes
, 2023 A nanocomposite material based on halloysite and α-lipoic acid was studied. The kinetics of the degradation process of α-lipoic acid under the influence of ultraviolet radiation and thermal stress in its native state and in the composition of
Olena Chyhyrynets +2 more
core +1 more source