Results 41 to 50 of about 4,202,272 (225)

Alpha-lipoic acid reduces body weight and regulates triglycerides in obese patients with diabetes mellitus [PDF]

Medicinski Glasnik, 2015
Aim To determine an influence of alpha-lipoic acid to reduction of body weight and regulation of total cholesterol concentration, triglycerides and glucose serum levels in obese patients with diabetes mellitus type 2.
Azra Okanović, Besim Prnjavorac, Edin Jusufović, Rifat Sejdinović   +3 more
doaj   +1 more source

Dihydro-alpha-lipoic acid has more potent cytotoxicity than alpha-lipoic acid

In Vitro Cellular & Developmental Biology - Animal, 2009
Alpha-lipoic acid has been shown to possess cancer-cell-killing activity via activation of the apoptosis pathway. In this study, the cytotoxic activities of alpha-lipoic and dihydro-alpha-lipoic acid were compared in HL-60 cells. The cell-killing activity of dihydro-alpha-lipoic acid was higher than that of alpha-lipoic acid.
Masao, Yamasaki, Akiko, Kawabe, Kentaro, Nishimoto, Harishkumar, Madhyastha, Yoichi, Sakakibara, Masahito, Suiko, Takeaki, Okamoto, Taiji, Suda, Kenzo, Uehira, Kazuo, Nishiyama   +9 more
openaire   +4 more sources

“Activation‐Resistance Elimination” Regulation by Lanthanide/Transition Metal Ion‐Coordinated Nanostructures Intensifies Cuproptosis and Tumor Immunotherapy

Advanced Materials, EarlyView.
The lanthanide/transition metal ion coordination nanoparticles, La‐Cu@Lap/IWR‐1, with optimized coordination, have been proven to achieve remarkable results in realizing comprehensive tumor cuproptosis through efficient cuproptosis activation and multidimensional resistance elimination, thereby synchronously realizing the synergistic antitumor effects ...
Junrong Wang, Mengqian Xu, Huaping Zhao, Yulin Xie, Guoqing Zhu, Haoze Li, Qianqian Sun, Yong Lei, Chunxia Li   +8 more
wiley   +1 more source

DLST Succinylation‐Mediated Mitochondrial Metabolic Remodeling and Cuproptosis Resistance Promote Malignant Progression of Lung Adenocarcinoma

Advanced Science, EarlyView.
The DLST K409 succinylation mediated by CPT1A promotes OXPHOS and redox homeostasis through regulating enzyme activity, thereby promoting the malignant progression of LUAD. Notably, the succinylation of DLST can enhance the cuproptosis resistance by inhibiting its lipoylation.
Xuanxuan Li, Peijun Zhou, Xingzhi Peng, Qixin Liu, Wenhui Zeng, Rui Wang, Liangfang Shen, Jinwu Peng, Qin Zhou, Lifang Yang   +9 more
wiley   +1 more source

Alpha-lipoic acid, an anti-obesity agent?

, 2004
Obesity shortens life expectancy and is a risk factor for hypertension and Type 2 diabetes. When added to the standard chow of Sprague-Dawley or Otsuka Long-Evans Tokushima Fatty rats, alpha-lipoic acid (0.5% weight/weight) reduced body weight and food ...
Doggrell, Sheila A
core   +1 more source

AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells

Advanced Science, EarlyView.
Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Mingtian Ding, Haibiao Xu, Cen Liu, Yangyin Ding, Shuai Wang, Jun Yin, Tao Fu, Xiao Jiang, Yuning Chen, Hui Luo, Rui Li, Zhengxin Chen, Huibo Wang   +12 more
wiley   +1 more source

THE POTENTIAL RENO-PROTECTIVE EFFECT OF ALPHA-LIPOIC ACID, MELATONIN, AND THEIR COMBINATION AGAINST PARACETAMOL-INDUCED NEPHROTOXICITY IN MALE RATS [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University
Objective: This study aimed to investigate the potential protective effects of alpha-lipoic acid (ALA), melatonin, and their combination on paracetamol-induced renal injury in male rats.
Huda Almosawi, Ausama Ayob Jaccob, Muhsin Al-Mozie'l   +2 more
doaj   +1 more source

Polyphosphate Copper Nanospheres Drive Mitochondrial Metabolic Reprogramming via Calcium Phase Separation for Self‐Sensitizing Cuproptosis

Advanced Science, EarlyView.
This study developed polyphosphate (polyP)‐based nanostructures that enable calcium‐mediated metabolic reprogramming via liquid–liquid phase separation (LLPS). Released polyP undergoes LLPS with Ca2+, suppressing glycolytic flux and enhancing mitochondrial metabolism effectively.
Jing Wang, Xinyang Zhao, Zifeng Huang, Jingyi Zhang, Yucheng Tao, Yong Huang, Zijian Guo, Lei Dong, Xiuxiu Wang, Jing Zhao, Wei Wei   +10 more
wiley   +1 more source

Alpha-lipoic acid in liver metabolism and disease.

, 1998
R-alpha-Lipoic acid is found naturally occurring as a prosthetic group in alpha-keto acid dehydrogenase complexes of the mitochondria, and as such plays a fundamental role in metabolism.
L. Packer, B. H. Rihn, H. J. Tritschler, MARCOCCI, Lucia, J. K. Lodge, J. Bustamante   +5 more
core   +1 more source

Efficacy of Using Alpha-Lipoic Acid in Diabetic Neuropathy

, 2015
The article presents a review of literature and research demonstrating the effectiveness of using alpha-lipoic acid in diabetic ...
V.I. Pankiv
core   +1 more source