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Diabetes and alpha lipoic acid [PDF]
Frontiers in Pharmacology, 2011 Diabetes mellitus is a multi-faceted metabolic disorder where there is increased oxidative stress that contributes to the pathogenesis of this debilitating disease.
Issy eLaher
doaj +7 more sources
Nutrients, 2023 Alpha-lipoic acid (ALA) was found to improve the symptoms in patients with diabetic sensorimotor peripheral neuropathy (DSPN) by reducing oxidative stress and ameliorating microcirculation.
Chiehfeng Chen, Jia-Ying Sung
exaly +2 more sources
Definitions, 2020 Alpha lipoic acid, or just lipoic acid (LA), is a unique and potent antioxidant. It can deliver antioxidant activity in both fatand water-soluble mediums, and it is capable of having an antioxidant effect in both its oxidized (LA) and reduced (DHLA ...
semanticscholar +2 more sources
Animals, 2021 Alpha-lipoic acid (a-LA) is used as a nutritive additive in dog food. Therefore, we performed a systematic review of studies published to date in PubMed, Google Scholar, Cochrane Library and MedlinePlus involving alpha-lipoic acid supplementation, which ...
Reshma M. Anthony +2 more
doaj +2 more sources
Alpha-Lipoic Acid as an Antioxidant Strategy for Managing Neuropathic Pain
Antioxidants, 2022 Neuropathic pain (NP) is the most prevalent and debilitating form of chronic pain, caused by injuries or diseases of the somatosensory system. Since current first-line treatments only provide poor symptomatic relief, the search for new therapeutic ...
Cristiane Flora Villarreal +2 more
exaly +2 more sources
In Silico and In Vitro Investigation of Apoptosis-Mediated Antiproliferative Activity of Capsaicin and Alpha-Lipoic Acid Against Prostate Cancer Cells [PDF]
Current Issues in Molecular BiologyNatural products are widely used in the treatment of cancer due to the side effects of chemotherapeutics, and a large number of natural compounds have been reported to have anticancer activities in different types of cancer.
Ogunc Meral +9 more
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Alpha-Lipoic Acid Is an Effective Nutritive Antioxidant for Healthy Adult Dogs
Animals, 2021 This study was designed to determine the effect of alpha-lipoic acid on the glutathione status in healthy adult dogs. Following a 15 month baseline period during which dogs were fed a food containing no alpha-lipoic acid, dogs were randomly allocated ...
Reshma M. Anthony +4 more
doaj +2 more sources
The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment
AntioxidantsAlpha-lipoic acid (ALA) is a naturally occurring compound synthesized by mitochondria and widely distributed in both animal and plant tissues. It primarily influences cellular metabolism and oxidative stress networks through its antioxidant properties ...
Jin-Zhu Wu, Shuai Yan
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Neuroprotective Effects of Alpha Lipoic Acid on Haloperidol-Induced Oxidative Stress in the Rat Brain [PDF]
Cell & Bioscience, 2011 Haloperidol is an antipsychotic drug that exerts its' antipsychotic effects by inhibiting dopaminergic neurons. Although the exact pathophysiology of haloperidol extrapyramidal symptoms are not known, the role of reactive oxygen species in inducing ...
Perera Joachim +4 more
doaj +2 more sources
Alpha lipoic acid in obstetrics and gynecology
Gynecological Endocrinology, 2018 Alpha-Lipoic acid (ALA) is a natural antioxidant synthetized by plants and animals, identified as a catalytic agent for oxidative decarboxylation of pyruvate and α-ketoglutarate. In this review, we analyzed the action of ALA in gynecology and obstetrics focusing in particular on neuropathic pain and antioxidant and anti-inflammatory action.
Pierluigi Benedetti Panici +2 more
exaly +4 more sources