Nitrated α-Synuclein Induces the Loss of Dopaminergic Neurons in the Substantia Nigra of Rats [PDF]
PLoS ONE, 2010 BACKGROUND: The pathology of Parkinson's disease (PD) is characterized by the degeneration of the nigrostriatal dopaminergic pathway, as well as the formation of intraneuronal inclusions known as Lewy bodies and Lewy neurites in the substantia nigra ...
A Abeliovich +70 more
core +29 more sources
Deposits of disease-associated alpha-synuclein may be present in the dura mater in Lewy body disorders: implications for potential inadvertent transmission by surgery [PDF]
Free Neuropathology, 2020 Deposition of alpha-synuclein in the brain is a hallmark of Lewy body disorders. Alpha-synuclein has been considered to show prion-like properties.
Budka, Herbert +7 more
core +4 more sources
Neural connectivity predicts spreading of alpha-synuclein pathology in fibril-injected mouse models: Involvement of retrograde and anterograde axonal propagation. [PDF]
Neurobiology of Disease, 2020 In Parkinson's disease, some of the first alpha-synuclein aggregates appear in the olfactory system and the dorsal motor nucleus of the vagus nerve before spreading to connected brain regions.
Brundin, Patrik +3 more
core +4 more sources
Targeted Extracellular Vesicle Gene Therapy for Modulating Alpha-Synuclein Expression in Gut and Spinal Cord [PDF]
Pharmaceutics, 2023 The development of effective disease-modifying therapies to halt Parkinson’s disease (PD) progression is required. In a subtype of PD patients, alpha-synuclein pathology may start in the enteric nervous system (ENS) or autonomic peripheral nervous system.
Alvarez-Erviti, Lydia +5 more
core +3 more sources
Microtubule Depolymerization Potentiates Alpha-Synuclein Oligomerization [PDF]
Frontiers in Aging Neuroscience, 2010 Parkinson's disease (PD) is associated with perturbed mitochondria function and alpha-synuclein fibrillization. We evaluated potential mechanistic links between mitochondrial dysfunction and alpha-synuclein aggregation. We studied a PD cytoplasmic hybrid
Arduíno, Daniela M. +4 more
core +5 more sources
C-elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging [PDF]
PLoS Genetics, 2008 Inclusions in the brain containing alpha-synuclein are the pathological hallmark of Parkinson's disease, but how these inclusions are formed and how this links to disease is poorly understood.
AA Cooper +38 more
core +10 more sources
CSP alpha reduces aggregates and rescues striatal dopamine release in alpha-synuclein transgenic mice [PDF]
, 2021 alpha-Synuclein aggregation at the synapse is an early event in Parkinson's disease and is associated with impaired striatal synaptic function and dopaminergic neuronal death.
Anichtchik, Oleg +9 more
core +1 more source
CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson’s disease [PDF]
, 2020 Parkinson’s disease (PD) affects millions of patients worldwide and is characterized by alpha-synuclein aggregation in dopamine neurons. Molecular tweezers have shown high potential as anti-aggregation agents targeting positively charged residues of ...
Bengoa-Vergniory, Nora +20 more
core +5 more sources
Direct detection of alpha synuclein oligomers in vivo [PDF]
, 2014 Background: Rat models of Parkinson’s disease are widely used to elucidate the mechanisms underlying disease etiology or to investigate therapeutic approaches.
Dimant, Hemi +9 more
core +1 more source
Dataset of total, oligomeric alpha-synuclein and hemoglobin levels in plasma in Parkinson׳s disease [PDF]
, 2017 This data article presents a dataset of total, oligomeric alpha-synuclein and hemoglobin levels in plasma of drug-naïve PD patients and controls. This is the first attempt to assess the effect of hemolysis rate on oligomeric alpha-synuclein levels in ...
Andoskin, P. +2 more
core +2 more sources