Results 1 to 10 of about 68,100 (329)

Alpha synuclein and inflammaging [PDF]

Heliyon
The α-synuclein protein is an established molecule in Lewy body pathology, especially Parkinson's disease (PD). While the pathological role of α-synuclein (α-syn) in PD has been well described, novel evidence may suggest that α-syn interacts with ...
Geneviève L. Putnam, Robert W. Maitta
doaj   +3 more sources

Neural connectivity predicts spreading of alpha-synuclein pathology in fibril-injected mouse models: Involvement of retrograde and anterograde axonal propagation [PDF]

Neurobiology of Disease, 2020
In Parkinson's disease, some of the first alpha-synuclein aggregates appear in the olfactory system and the dorsal motor nucleus of the vagus nerve before spreading to connected brain regions.
Christopher Mezias, Nolwen Rey, Patrik Brundin, Ashish Raj   +3 more
doaj   +4 more sources

C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging. [PDF]

PLoS Genetics, 2008
Inclusions in the brain containing alpha-synuclein are the pathological hallmark of Parkinson's disease, but how these inclusions are formed and how this links to disease is poorly understood. We have developed a C.
Tjakko J van Ham, Karen L Thijssen, Rainer Breitling, Robert M W Hofstra, Ronald H A Plasterk, Ellen A A Nollen   +5 more
doaj   +11 more sources

Dermal Alpha-Synuclein Aggregation in Seed Amplification Assays for Parkinson's Disease Subtype Differentiation. [PDF]

Eur J Neurol
Vieregge M, Kuzkina A, Janzen A, Oertel WH, Sommerauer M, Volkmann J, Doppler K.   +6 more
europepmc   +3 more sources

Site-specific perturbations of alpha-synuclein fibril structure by the Parkinson's disease associated mutations A53T and E46K. [PDF]

, 2013
PMCID: PMC3591419This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited ...
A Loquet, BI Giasson, BM Fung, C Wasmer, Chad M. Rienstra, CP Jaroniec, CR Bodner, CR Morcombe, D Eliezer, DS Wishart, DS Wishart, DS Wishart, E Oldfield, EA Greenbaum, Elisa Greggio, F Delaglio, G Comellas, G Comellas, G Comellas, G Cornilescu, Gemma Comellas, H Heise, H Heise, H van Melckebeke, J Li, JJ Zarranz, Julia M. George, K Iwata, K Takegoshi, KA Conway, KD Kloepper, L Narhi, Lars K. Rikardsen, LC Serpell, LR Lemkau, Luisel R. Lemkau, M Baldus, ME van Raaij, MG Spillantini, MH Polymeropoulos, MS Celej, N Ferguson, R Bussell, R Kruger, RA Fredenburg, S Hediger, Shin W. Lee, W Choi, Wendy S. Woods, WG Hoyer, Y Shen   +50 more
core   +17 more sources

Inhibition of calpain prevents manganese-induced cell injury and alpha-synuclein oligomerization in organotypic brain slice cultures. [PDF]

PLoS ONE, 2015
Overexposure to manganese has been known to promote alpha-synuclein oligomerization and enhance cellular toxicity. However, the exact mechanism of Mn-induced alpha-synuclein oligomerization is unclear.
Bin Xu, Wei Liu, Yu Deng, Tian-Yao Yang, Shu Feng, Zhao-Fa Xu   +5 more
doaj   +1 more source

Alpha-synuclein suppression by targeted small interfering RNA in the primate substantia nigra. [PDF]

PLoS ONE, 2010
The protein alpha-synuclein is involved in the pathogenesis of Parkinson's disease and other neurodegenerative disorders. Its toxic potential appears to be enhanced by increased protein expression, providing a compelling rationale for therapeutic ...
Alison L McCormack, Sally K Mak, Jaimie M Henderson, David Bumcrot, Matthew J Farrer, Donato A Di Monte   +5 more
doaj   +1 more source

Toward a Disease-Modifying Therapy of Alpha-Synucleinopathies: New Molecules and New Approaches Came into the Limelight

Molecules, 2021
The accumulation of the various products of alpha-synuclein aggregation has been associated with the etiology and pathogenesis of several neurodegenerative conditions, including both familial and sporadic forms of Parkinson’s disease (PD) and dementia ...
Mae Upcott, Kirill D. Chaprov, Vladimir L. Buchman   +2 more
doaj   +1 more source

The HSP70 molecular chaperone is not beneficial in a mouse model of alpha-synucleinopathy. [PDF]

PLoS ONE, 2010
BACKGROUND: Aggregation and misfolded alpha-synuclein is thought to be central in the pathogenesis of Parkinson's disease (PD). Heat-shock proteins (HSPs) that are involved in refolding and degradation processes could lower the aggregate load of alpha ...
Derya R Shimshek, Matthias Mueller, Christoph Wiessner, Tatjana Schweizer, P Herman van der Putten   +4 more
doaj   +1 more source

Preanalytical Stability of CSF Total and Oligomeric Alpha-Synuclein

Frontiers in Aging Neuroscience, 2021
Background: The role of cerebrospinal fluid (CSF) alpha-synuclein as a potential biomarker has been challenged mainly due to variable preanalytical measures between laboratories.
Ilham Y. Abdi, Nour K. Majbour, Eline A. J. Willemse, Wilma D. J. van de Berg, Brit Mollenhauer, Brit Mollenhauer, Charlotte E. Teunissen, Omar M. El-Agnaf   +7 more
doaj   +1 more source