Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
Neurobiology of Disease, 2011 Alpha-synuclein aggregation plays a central role in Parkinson's disease pathology. Direct transmission of alpha-synuclein from pathologically affected to healthy unaffected neurons may be important in the anatomical spread of the disease through the ...
Lydia Alvarez-Erviti +6 more
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A split biotin ligase approach reveals proteins associated with oligomeric alpha-synuclein during aggregation [PDF]
Scientific ReportsLewy pathology can form over decades in patients with Lewy body diseases, but the causal cellular mechanisms associated with this process remain unclear.
Analiese R. Fernandes +13 more
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Inhibition of calpain prevents manganese-induced cell injury and alpha-synuclein oligomerization in organotypic brain slice cultures. [PDF]
PLoS ONE, 2015 Overexposure to manganese has been known to promote alpha-synuclein oligomerization and enhance cellular toxicity. However, the exact mechanism of Mn-induced alpha-synuclein oligomerization is unclear.
Bin Xu +5 more
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Alpha-synuclein suppression by targeted small interfering RNA in the primate substantia nigra. [PDF]
PLoS ONE, 2010 The protein alpha-synuclein is involved in the pathogenesis of Parkinson's disease and other neurodegenerative disorders. Its toxic potential appears to be enhanced by increased protein expression, providing a compelling rationale for therapeutic ...
Alison L McCormack +5 more
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Preanalytical Stability of CSF Total and Oligomeric Alpha-Synuclein
Frontiers in Aging Neuroscience, 2021 Background: The role of cerebrospinal fluid (CSF) alpha-synuclein as a potential biomarker has been challenged mainly due to variable preanalytical measures between laboratories.
Ilham Y. Abdi +7 more
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Formation of toxic oligomeric alpha-synuclein species in living cells. [PDF]
PLoS ONE, 2008 Misfolding, oligomerization, and fibrillization of alpha-synuclein are thought to be central events in the onset and progression of Parkinson's disease (PD) and related disorders.
Tiago Fleming Outeiro +7 more
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Molecules, 2021 The accumulation of the various products of alpha-synuclein aggregation has been associated with the etiology and pathogenesis of several neurodegenerative conditions, including both familial and sporadic forms of Parkinson’s disease (PD) and dementia ...
Mae Upcott +2 more
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The HSP70 molecular chaperone is not beneficial in a mouse model of alpha-synucleinopathy. [PDF]
PLoS ONE, 2010 BACKGROUND: Aggregation and misfolded alpha-synuclein is thought to be central in the pathogenesis of Parkinson's disease (PD). Heat-shock proteins (HSPs) that are involved in refolding and degradation processes could lower the aggregate load of alpha ...
Derya R Shimshek +4 more
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Nitrated alpha-synuclein induces the loss of dopaminergic neurons in the substantia nigra of rats. [PDF]
PLoS ONE, 2010 BACKGROUND: The pathology of Parkinson's disease (PD) is characterized by the degeneration of the nigrostriatal dopaminergic pathway, as well as the formation of intraneuronal inclusions known as Lewy bodies and Lewy neurites in the substantia nigra ...
Zhongwang Yu +6 more
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Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy. [PDF]
PLoS ONE, 2009 In synucleinopathies, including Parkinson's disease, partially ubiquitylated alpha-synuclein species phosphorylated on serine 129 (P(S129)-alpha-synuclein) accumulate abnormally.
Margot Fournier +22 more
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