Results 1 to 10 of about 1,144,970 (369)
Alpha synuclein and inflammaging [PDF]
HeliyonThe α-synuclein protein is an established molecule in Lewy body pathology, especially Parkinson's disease (PD). While the pathological role of α-synuclein (α-syn) in PD has been well described, novel evidence may suggest that α-syn interacts with ...
Geneviève L. Putnam, Robert W. Maitta
doaj +3 more sources
Alpha Synuclein: Neurodegeneration and Inflammation
International Journal of Molecular Sciences, 2023 Alpha-Synuclein (α-Syn) is one of the most important molecules involved in the pathogenesis of Parkinson’s disease and related disorders, synucleinopathies, but also in several other neurodegenerative disorders with a more elusive role.
G. Forloni
semanticscholar +3 more sources
The inhibitory effect of pyrroloquinoline quinone on the amyloid formation and cytotoxicity of truncated alpha-synuclein [PDF]
Molecular Neurodegeneration, 2010 Background Parkinson's disease (PD) involves the selective damage of dopaminergic neuron cells resulting from the accumulation and fibril formation of alpha-synuclein.
Kobayashi Natsuki +4 more
doaj +2 more sources
The relationship of alpha-synuclein to mitochondrial dynamics and quality control
Frontiers in Molecular Neuroscience, 2022 Maintenance of mitochondrial health is essential for neuronal survival and relies upon dynamic changes in the mitochondrial network and effective mitochondrial quality control mechanisms including the mitochondrial-derived vesicle pathway and mitophagy ...
Naomi J. Thorne, David A. Tumbarello
doaj +2 more sources
Targeting Alpha-Synuclein as a Therapy for Parkinson’s Disease
Frontiers in Molecular Neuroscience, 2019 Parkinson’s disease (PD) is one of the most common neurodegenerative disorders with a global burden of approximately 6.1 million patients. Alpha-synuclein has been linked to both the sporadic and familial forms of the disease.
Carroll Rutherford Fields +2 more
doaj +2 more sources
Cell Death and Disease, 2023 Although the discovery of the critical role of α-synuclein (α-syn) in the pathogenesis of Parkinson’s disease (PD) is now twenty-five years old, it still represents a milestone in PD research.
P. Calabresi +5 more
semanticscholar +1 more source
Advances in understanding the function of alpha-synuclein: implications for Parkinson’s disease
Brain : a journal of neurology, 2023 The critical role of alpha-synuclein in Parkinson’s disease represents a pivotal discovery. Some progress has been made over recent years in identifying disease-modifying therapies for Parkinson’s disease that target alpha-synuclein.
P. Calabresi +4 more
semanticscholar +1 more source
Small molecules disaggregate alpha-synuclein and prevent seeding from patient brain-derived fibrils
Proceedings of the National Academy of Sciences of the United States of America, 2023 Significance Parkinson’s disease (PD) and the related condition multiple system atrophy (MSA) are associated with the aggregation of the protein alpha-synuclein into fibrils within the brain. Disaggregation of these fibrils could possibly slow or reverse
K. Murray +13 more
semanticscholar +1 more source
Acta Neuropathologica Communications, 2021 Alpha-synuclein seed amplification assays (αSyn-SAAs) are promising diagnostic tools for Parkinson’s disease (PD) and related synucleinopathies. They enable detection of seeding-competent alpha-synuclein aggregates in living patients and have shown high ...
Marco J. Russo +17 more
semanticscholar +1 more source
Inhibition of calpain prevents manganese-induced cell injury and alpha-synuclein oligomerization in organotypic brain slice cultures. [PDF]
PLoS ONE, 2015 Overexposure to manganese has been known to promote alpha-synuclein oligomerization and enhance cellular toxicity. However, the exact mechanism of Mn-induced alpha-synuclein oligomerization is unclear.
Bin Xu +5 more
doaj +1 more source