The inhibitory effect of pyrroloquinoline quinone on the amyloid formation and cytotoxicity of truncated alpha-synuclein [PDF]
Molecular Neurodegeneration, 2010 Background Parkinson's disease (PD) involves the selective damage of dopaminergic neuron cells resulting from the accumulation and fibril formation of alpha-synuclein.
Kobayashi Natsuki +4 more
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Alpha synuclein and inflammaging. [PDF]
HeliyonThe α-synuclein protein is an established molecule in Lewy body pathology, especially Parkinson's disease (PD). While the pathological role of α-synuclein (α-syn) in PD has been well described, novel evidence may suggest that α-syn interacts with ...
Putnam GL, Maitta RW.
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Inhibition of calpain prevents manganese-induced cell injury and alpha-synuclein oligomerization in organotypic brain slice cultures. [PDF]
PLoS ONE, 2015 Overexposure to manganese has been known to promote alpha-synuclein oligomerization and enhance cellular toxicity. However, the exact mechanism of Mn-induced alpha-synuclein oligomerization is unclear.
Bin Xu +5 more
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Alpha-synuclein suppression by targeted small interfering RNA in the primate substantia nigra. [PDF]
PLoS ONE, 2010 The protein alpha-synuclein is involved in the pathogenesis of Parkinson's disease and other neurodegenerative disorders. Its toxic potential appears to be enhanced by increased protein expression, providing a compelling rationale for therapeutic ...
Alison L McCormack +5 more
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Molecules, 2021 The accumulation of the various products of alpha-synuclein aggregation has been associated with the etiology and pathogenesis of several neurodegenerative conditions, including both familial and sporadic forms of Parkinson’s disease (PD) and dementia ...
Matthew Upcott +2 more
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Formation of toxic oligomeric alpha-synuclein species in living cells. [PDF]
PLoS ONE, 2008 Misfolding, oligomerization, and fibrillization of alpha-synuclein are thought to be central events in the onset and progression of Parkinson's disease (PD) and related disorders.
Tiago Fleming Outeiro +7 more
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Preanalytical Stability of CSF Total and Oligomeric Alpha-Synuclein
Frontiers in Aging Neuroscience, 2021 Background: The role of cerebrospinal fluid (CSF) alpha-synuclein as a potential biomarker has been challenged mainly due to variable preanalytical measures between laboratories.
Ilham Y. Abdi +7 more
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Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy. [PDF]
PLoS ONE, 2009 In synucleinopathies, including Parkinson's disease, partially ubiquitylated alpha-synuclein species phosphorylated on serine 129 (P(S129)-alpha-synuclein) accumulate abnormally.
Margot Fournier +22 more
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Targeting Alpha-Synuclein as a Therapy for Parkinson’s Disease
Frontiers in Molecular Neuroscience, 2019 Parkinson’s disease (PD) is one of the most common neurodegenerative disorders with a global burden of approximately 6.1 million patients. Alpha-synuclein has been linked to both the sporadic and familial forms of the disease.
Carroll Rutherford Fields +2 more
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Transcriptional regulation of the beta-synuclein 5'-promoter metal response element by metal transcription factor-1. [PDF]
PLoS ONE, 2011 The progression of many human neurodegenerative disorders is associated with an accumulation of alpha-synuclein. Alpha-synuclein belongs to the homologous synuclein family, which includes beta-synuclein.
Patrick C McHugh +2 more
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