Results 11 to 20 of about 31,365 (260)

Alpha synuclein and inflammaging

Heliyon
The α-synuclein protein is an established molecule in Lewy body pathology, especially Parkinson's disease (PD). While the pathological role of α-synuclein (α-syn) in PD has been well described, novel evidence may suggest that α-syn interacts with ...
Geneviève L. Putnam, Robert W. Maitta
doaj   +2 more sources

Microtubule depolymerization potentiates alpha-synuclein oligomerization [PDF]

Frontiers in Aging Neuroscience, 2010
Parkinson’s disease (PD) is associated with perturbed mitochondria function and alpha-synuclein fibrillization. We evaluated potential mechanistic links between mitochondrial dysfunction and alpha-synuclein aggregation.
Russell H Swerdlow, Catarina Oliveira
doaj   +3 more sources

Alpha synuclein in hematopoiesis and immunity

Heliyon, 2019
Parkinson's disease (PD) is the second most common neurodegenerative condition and intracellular deposition of Lewy bodies in the substantia nigra (SN), which can cause dopaminergic neuronal death, is the hallmark of this syndrome. α-synuclein (syn) is a
Yu Pei, Robert W. Maitta
doaj   +3 more sources

Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein

Scientific Reports, 2022
AbstractParkinson′s disease (PD) pathology progresses throughout the nervous system affecting numerous neuronal structures. It has been postulated that the progression of the pathology is based on a prion-like disease mechanism partly due to the seeding effect of endocytosed alpha-synuclein (ASYN) on the endogenous ASYN. The appearance of the pathology
Yanina Dening, Theresa Straßl, Viktoria Ruf, Petra Dirscherl, Alexandra Chovsepian, Alicia Stievenard, Amit Khairnar, Felix Schmidt, Florian Giesert, Jochen Herms, Johannes Levin, Marianne Dieterich, Peter Falkai, Daniela Vogt Weisenhorn, Wolfgang Wurst, Armin Giese, Francisco Pan-Montojo   +16 more
openaire   +6 more sources

Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells [PDF]

Neuroscience Letters, 2008
Alpha-synuclein (alpha-syn) is implicated in the pathogenesis of Parkinson's disease (PD). Mutations in alpha-syn gene or alpha-syn locus (SNCA) triplication are associated with mitochondrial abnormalities and early onset of familial PD. The goals of the present study were to examine whether alpha-syn is localized in the mitochondria of alpha-syn ...
Shaik, Shavali, Holly M, Brown-Borg, Manuchair, Ebadi, James, Porter   +3 more
openaire   +2 more sources

Anti-α-synuclein c-terminal antibodies block PFF uptake and accumulation of phospho-synuclein in preclinical models of Parkinson's disease

Neurobiology of Disease, 2023
Parkinson's disease (PD), a neurodegenerative disease affecting dopaminergic (DA) neurons, is characterized by decline of motor function and cognition. Dopaminergic cell loss is associated with accumulation of toxic alpha synuclein aggregates.
Robert Brendza, Xiaoying Gao, Kimberly L. Stark, Han Lin, Seung-Hye Lee, Changyun Hu, Hao Cai, Danielle DiCara, Yi-Chun Hsiao, Hai Ngu, Oded Foreman, Miriam Baca, Monika Dohse, Jean-Phillipe Fortin, Racquel Corpuz, Dhaya Seshasayee, Amy Easton, Gai Ayalon, Isidro Hötzel, Ben Chih   +19 more
doaj   +1 more source

Synapsin Condensates Recruit alpha-Synuclein

Journal of Molecular Biology, 2021
Neurotransmission relies on the tight spatial and temporal regulation of the synaptic vesicle (SV) cycle. Nerve terminals contain hundreds of SVs that form tight clusters. These clusters represent a distinct liquid phase in which one component of the phase are SVs and the other synapsin 1, a highly abundant synaptic protein.
Hoffmann, Christian, Sansevrino, Roberto, Morabito, Giuseppe, Logan, Chinyere, Vabulas, R Martin, Ulusoy, Ayse, Ganzella, Marcelo, Milovanovic, Dragomir   +7 more
openaire   +4 more sources

Targeting Alpha-Synuclein as a Therapy for Parkinson’s Disease

Frontiers in Molecular Neuroscience, 2019
Parkinson’s disease (PD) is one of the most common neurodegenerative disorders with a global burden of approximately 6.1 million patients. Alpha-synuclein has been linked to both the sporadic and familial forms of the disease.
Carroll Rutherford Fields, Nora Bengoa-Vergniory, Richard Wade-Martins   +2 more
doaj   +1 more source

Targeted Extracellular Vesicle Gene Therapy for Modulating Alpha-Synuclein Expression in Gut and Spinal Cord

Pharmaceutics, 2023
The development of effective disease-modifying therapies to halt Parkinson’s disease (PD) progression is required. In a subtype of PD patients, alpha-synuclein pathology may start in the enteric nervous system (ENS) or autonomic peripheral nervous system.
Maria Izco, Martin Schleef, Marco Schmeer, Estefania Carlos, Guglielmo Verona, Lydia Alvarez-Erviti   +5 more
doaj   +1 more source

Alpha-synuclein modulates dopamine neurotransmission [PDF]

Journal of Chemical Neuroanatomy, 2017
Alpha-synuclein is a small, highly charged protein encoded by the synuclein or SNCA gene that is predominantly expressed in central nervous system neurons. Although its physiological function remains enigmatic, alpha-synuclein is implicated in movement disorders such as Parkinson's disease, multiple system atrophy, and in neurodegenerative diseases ...
Brittany Butler, Danielle Sambo, Habibeh Khoshbouei   +2 more
openaire   +2 more sources