Results 21 to 30 of about 1,144,970 (369)

The Localization of Alpha-synuclein in the Endocytic Pathway [PDF]

Neuroscience, 2021
Alpha-synuclein (αS) is an intrinsically disordered protein (IDP) that is abundantly present in the brain and is associated with Parkinson's disease (PD). In spite of its abundance and its contribution to PD pathogenesis, the exact cellular function of αS remains largely unknown.
Fakhree, Mohammad A.A., Konings, Irene B. M., Kole, Jeroen, Cambi, A., Blum, Christian, Claessens, Mireille M.A.E.   +5 more
openaire   +4 more sources

Alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy

Translational Neurodegeneration, 2022
Background Multiple system atrophy (MSA) is a neurodegenerative condition characterized by variable combinations of parkinsonism, autonomic failure, cerebellar ataxia and pyramidal features.
Iván Martínez-Valbuena, N. Visanji, Ain Kim, Heather H. C. Lau, Raphaella W. L. So, Sohaila A Alshimemeri, A. Gao, M. Seidman, M. Luquin, J. Watts, A. Lang, G. Kovacs   +11 more
semanticscholar   +1 more source

SUMOylation of Alpha-Synuclein Influences on Alpha-Synuclein Aggregation Induced by Methamphetamine [PDF]

Frontiers in Cellular Neuroscience, 2018
Methamphetamine (METH) is an illegal and widely abused psychoactive stimulant. METH abusers are at high risk of neurodegenerative disorders, including Parkinson's disease (PD). Previous studies have demonstrated that METH causes alpha-synuclein (α-syn) aggregation in the both laboratory animal and human.
Honghua Qiao, Ling Chen, Jiuyang Ding, Jiuyang Ding, Yongling Lian, Lin-Nan Zhu, Le-ping Sun, Bo-feng Zhu, Wei-Bing Xie, Jialiang Hui, Pingming Qiu, Yunle Meng   +11 more
openaire   +4 more sources

Alpha synuclein determines ferroptosis sensitivity in dopaminergic neurons via modulation of ether-phospholipid membrane composition.

Cell Reports, 2022
There is a continued unmet need for treatments that can slow Parkinson's disease progression due to the lack of understanding behind the molecular mechanisms underlying neurodegeneration.
Laura Mahoney-Sánchez, H. Bouchaoui, I. Boussaad, A. Jonneaux, Kelly Timmerman, O. Berdeaux, S. Ayton, R. Krüger, J. Duce, D. Devos, J. Devedjian   +10 more
semanticscholar   +1 more source

Alpha-Synuclein FRET Biosensors Reveal Early Alpha-Synuclein Aggregation in the Endoplasmic Reticulum [PDF]

Life, 2020
Endoplasmic reticulum (ER) dysfunction is important for alpha-synuclein (αS) acquired toxicity. When targeted to the ER in SH-SY5Y cells, transient or stable expression of αS resulted in the formation of compact αS-positive structures in a small subpopulation of cells, resembling αS inclusions. Thus, because of the limitations of immunofluorescence, we
Fabiana Miraglia, Verdiana Valvano, Lucia Rota, Cristina Di Primio, Valentina Quercioli, Laura Betti, Gino Giannaccini, Antonino Cattaneo, Emanuela Colla   +8 more
openaire   +4 more sources

Alpha-synuclein supports type 1 interferon signalling in neurons and brain tissue.

Brain : a journal of neurology, 2022
The protein alpha-synuclein is predominantly expressed in neurons and is associated with neurodegenerative diseases like Parkinson's disease and dementia with Lewy bodies. However, the normal function of alpha-synuclein in neurons is not clearly defined.
Brendan Monogue, Yixi Chen, Hadrian Sparks, R. Behbehani, A. Chai, Alexander J. Rajic, A. Massey, B. Kleinschmidt‐DeMasters, M. Vermeren, T. Kunath, J. Beckham   +10 more
semanticscholar   +1 more source

Alpha-synuclein suppression by targeted small interfering RNA in the primate substantia nigra. [PDF]

PLoS ONE, 2010
The protein alpha-synuclein is involved in the pathogenesis of Parkinson's disease and other neurodegenerative disorders. Its toxic potential appears to be enhanced by increased protein expression, providing a compelling rationale for therapeutic ...
Alison L McCormack, Sally K Mak, Jaimie M Henderson, David Bumcrot, Matthew J Farrer, Donato A Di Monte   +5 more
doaj   +1 more source

The HSP70 molecular chaperone is not beneficial in a mouse model of alpha-synucleinopathy. [PDF]

PLoS ONE, 2010
BACKGROUND: Aggregation and misfolded alpha-synuclein is thought to be central in the pathogenesis of Parkinson's disease (PD). Heat-shock proteins (HSPs) that are involved in refolding and degradation processes could lower the aggregate load of alpha ...
Derya R Shimshek, Matthias Mueller, Christoph Wiessner, Tatjana Schweizer, P Herman van der Putten   +4 more
doaj   +1 more source

Toward a Disease-Modifying Therapy of Alpha-Synucleinopathies: New Molecules and New Approaches Came into the Limelight

Molecules, 2021
The accumulation of the various products of alpha-synuclein aggregation has been associated with the etiology and pathogenesis of several neurodegenerative conditions, including both familial and sporadic forms of Parkinson’s disease (PD) and dementia ...
Mae Upcott, Kirill D. Chaprov, Vladimir L. Buchman   +2 more
doaj   +1 more source

Ageing promotes pathological alpha-synuclein propagation and autonomic dysfunction in wild-type rats

Brain : a journal of neurology, 2021
Neuronal aggregates of misfolded alpha-synuclein protein are found in the brain and periphery of patients with Parkinson’s disease. Braak and colleagues have hypothesized that the initial formation of misfolded alpha-synuclein may start in the gut, and ...
Nathalie Van Den Berge, Nelson Ferreira, T. Mikkelsen, A. Alstrup, Gültekin Tamgüney, P. Karlsson, A. Terkelsen, J. Nyengaard, P. Jensen, P. Borghammer   +9 more
semanticscholar   +1 more source