Results 21 to 30 of about 59,298 (179)
Alpha-synuclein levels in blood plasma decline with healthy aging. [PDF]
PLoS ONE, 2015 There is unequivocal evidence that alpha-synuclein plays a pivotal pathophysiological role in neurodegenerative diseases, and in particular in synucleinopathies.
Niklas K U Koehler +14 more
doaj +1 more source
Journal of Analytical Methods in Chemistry, 2019 Parkinson’s disease (PD) is a progressive health issue and influences an increasingly larger number of people, especially at older ages, affecting the central nervous system (CNS).
Xuemei You +3 more
doaj +1 more source
Functions of Intracellular Alpha-Synuclein in Microglia: Implications for Parkinson’s Disease Risk
Frontiers in Cellular Neuroscience, 2021 Alpha-synuclein accumulation in dopaminergic neurons is one of the primary features of Parkinson’s disease (PD). Despite its toxic properties during PD, alpha-synuclein has some important physiological functions.
Alix Booms, Gerhard A. Coetzee
doaj +1 more source
Scientific Reports, 2023 Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, but no disease modifying therapies have been successful in clinical translation presenting a major unmet medical need.
Danuta Sastre +7 more
doaj +1 more source
Associations of sleep characteristics with alpha‐synuclein in cerebrospinal fluid in older adults
Annals of Clinical and Translational Neurology, 2020 Objective Sleep disorders as a preclinical symptom of synucleinopathies become more prevalent in older adults. Synucleinopathies might be caused by the abnormal aggregation of alpha‐synuclein in the brain, which was indicated by alpha‐synuclein levels in
Xiao‐Tong Wang +7 more
doaj +1 more source
Colonic Alpha-Synuclein as Potential Early Biomarker for Parkinson's Disease Dementia [PDF]
Iranian Journal of Colorectal Research, 2022 Parkinson's Disease Dementia (PDD) is a cognitive and reasoning decline in many patients living with Parkinson's disease at least a year following diagnosis. PDD must be detected and treated promptly, as its advancement might impair the patient's quality
Elvan Wiyarta
doaj +1 more source
Dopamine-induced conformational changes in alpha-synuclein. [PDF]
PLoS ONE, 2009 Oligomerization and aggregation of alpha-synuclein molecules play a major role in neuronal dysfunction and loss in Parkinson's disease [1]. However, alpha-synuclein oligomerization and aggregation have mostly been detected indirectly in cells using ...
Tiago F Outeiro +8 more
doaj +1 more source
Insight Into Parkinson\u27s Disease Using Yeast as a Model to Evaluate the Role of Autophagy Genes in alpha-Synuclein Toxicity [PDF]
, 2010 Parkinson’s disease is a fatal and incurable human neurodegenerative disorder that destroys midbrain neurons. The misfolding, accumulation, and aggregation of the protein alpha-synuclein is thought to kill these cells.
Alessandro M. Forte +3 more
core +4 more sources
Association between Serum Alpha-Synuclein Levels and Parkinson's Disease Stage
Global Medical & Health Communication, 2022 Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's. It is chronically progressive with the main symptoms of resting tremor, rigidity, bradykinesia, and postural disturbances.
Yuliarni Syafrita, Restu Susanti
doaj +1 more source
Behavioural deficits in transgenic mice expressing human truncated (1-120 amino acid) alpha-synuclein. [PDF]
, 2014 Accumulation and aggregation of alpha-synuclein in cortical and hippocampal areas is a pathological sign for dementia with Lewy bodies (DLB) and Parkinson's disease with dementia.
Anichtchik, Oleg +4 more
core +2 more sources