Results 31 to 40 of about 31,365 (260)
Dopamine-induced conformational changes in alpha-synuclein. [PDF]
PLoS ONE, 2009 Oligomerization and aggregation of alpha-synuclein molecules play a major role in neuronal dysfunction and loss in Parkinson's disease [1]. However, alpha-synuclein oligomerization and aggregation have mostly been detected indirectly in cells using ...
Tiago F Outeiro +8 more
doaj +1 more source
Alpha Synuclein: Neurodegeneration and Inflammation
International Journal of Molecular Sciences, 2023 Alpha-Synuclein (α-Syn) is one of the most important molecules involved in the pathogenesis of Parkinson’s disease and related disorders, synucleinopathies, but also in several other neurodegenerative disorders with a more elusive role. This review analyzes the activities of α-Syn, in different conformational states, monomeric, oligomeric and fibrils ...
openaire +2 more sources
p27Kip1 regulates alpha-synuclein expression
Oncotarget, 2018 Alpha-synuclein (α-SYN) is the main component of anomalous protein aggregates (Lewy bodies) that play a crucial role in several neurodegenerative diseases (synucleinopathies) like Parkinson's disease and multiple system atrophy. However, the mechanisms involved in its transcriptional regulation are poorly understood.
Gallastegui Calvache, Edurne, 1982- +12 more
openaire +5 more sources
Alpha-synuclein spreading in Parkinson’s disease [PDF]
Frontiers in Neuroanatomy, 2014 Formation and accumulation of misfolded protein aggregates are a central hallmark of several neurodegenerative diseases. In Parkinson's disease (PD), the aggregation-prone protein alpha-synuclein (α-syn) is the culprit. In the past few years, another piece of the puzzle has been added with data suggesting that α-syn may self-propagate, thereby ...
Recasens, Ariadna, Dehay, Benjamin
openaire +4 more sources
SUMOylation of Alpha-Synuclein Influences on Alpha-Synuclein Aggregation Induced by Methamphetamine [PDF]
Frontiers in Cellular Neuroscience, 2018 Methamphetamine (METH) is an illegal and widely abused psychoactive stimulant. METH abusers are at high risk of neurodegenerative disorders, including Parkinson's disease (PD). Previous studies have demonstrated that METH causes alpha-synuclein (α-syn) aggregation in the both laboratory animal and human.
Lin-nan Zhu +11 more
openaire +3 more sources
Parkinson's disease-related protein, alpha-synuclein, in malignant melanoma. [PDF]
PLoS ONE, 2010 Melanoma is the major cause of skin cancer death worldwide. Parkinson's disease is a neurodegenerative disorder that is caused by mutation of alpha-synuclein or other genes. Importantly, epidemiological studies have reported co-occurrence of melanoma and
Yasuhiro Matsuo, Tetsu Kamitani
doaj +1 more source
Neurobiology of Disease, 2023 The role of alpha-synuclein in Parkinson's disease has been heavily investigated since its discovery as a component of Lewy bodies. Recent rodent data demonstrate that alpha-synuclein strain structure is critical for differential propagation and toxicity.
Audrey Fayard +15 more
doaj +1 more source
Synaptic Changes in Mice Lacking Alpha- and Gamma-Synucleins
BiomedicinesBackground: Alpha-synuclein is a key protein involved in the pathogenesis of Parkinson disease (PD). Its intermediate aggregated forms disturb the normal function of dopaminergic (DA) neurons.
Anastasia M. Krayushkina +5 more
doaj +1 more source
Associations of sleep characteristics with alpha‐synuclein in cerebrospinal fluid in older adults
Annals of Clinical and Translational Neurology, 2020 Objective Sleep disorders as a preclinical symptom of synucleinopathies become more prevalent in older adults. Synucleinopathies might be caused by the abnormal aggregation of alpha‐synuclein in the brain, which was indicated by alpha‐synuclein levels in
Xiao‐Tong Wang +7 more
doaj +1 more source
Parkinson's disease (PD) is the most common neurodegenerative disease
Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2015 Metabolic impairment of alpha-synuclein protein is considered to be the central event in PDpathogenesis. Recent studies explored usage of alpha-synuclein in peripheral fluids as a biomarker of PD, however alpha-synuclein level in the CSF and plasma is ...
P. A. Andoskin +7 more
doaj +1 more source