Ubiquitination of alpha-synuclein filaments by Nedd4 ligases. [PDF]
PLoS ONE, 2018 Alpha-synuclein can form beta-sheet filaments, the accumulation of which plays a key role in the development of Parkinson's disease, dementia with Lewy bodies and multiple system atrophy.
Thomas Mund +3 more
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Alpha Synuclein Toxicity and Non-Motor Parkinson's. [PDF]
CellsParkinson’s disease (PD) is a common multisystem neurodegenerative disorder affecting 1% of the population over the age of 60 years. The main neuropathological features of PD are the loss of dopaminergic neurons in the substantia nigra pars compacta ...
Mazzotta GM, Conte C.
europepmc +2 more sources
C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction. [PDF]
, 2018 Alpha-synuclein is known to bind to small unilamellar vesicles (SUVs) via its N terminus, which forms an amphipathic alpha-helix upon membrane interaction.
Curry, Nathan +19 more
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How is alpha‐synuclein cleared from the cell? [PDF]
, 2019 The levels and conformers of alpha‐synuclein are critical in the pathogenesis of Parkinson's Disease and related synucleinopathies. Homeostatic mechanisms in protein degradation and secretion have been identified as regulators of alpha‐synuclein at ...
Emmanouilidou, E +5 more
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Parkinson's disease (PD) is the most common neurodegenerative disease
Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2015 Metabolic impairment of alpha-synuclein protein is considered to be the central event in PDpathogenesis. Recent studies explored usage of alpha-synuclein in peripheral fluids as a biomarker of PD, however alpha-synuclein level in the CSF and plasma is ...
P. A. Andoskin +7 more
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The relationship of alpha-synuclein to mitochondrial dynamics and quality control
Frontiers in Molecular Neuroscience, 2022 Maintenance of mitochondrial health is essential for neuronal survival and relies upon dynamic changes in the mitochondrial network and effective mitochondrial quality control mechanisms including the mitochondrial-derived vesicle pathway and mitophagy ...
Naomi J. Thorne, David A. Tumbarello
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The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen [PDF]
, 2011 Increased brain α-synuclein (SNCA) protein expression resulting from gene duplication and triplication can cause a familial form of Parkinson's disease (PD).
Bandyopadhyay, Sanghamitra +9 more
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Electron microscopy analysis of alpha-synuclein and LRRK2 transgenic C. elegans [PDF]
, 2013 Thesis (M.A.)--Boston UniversityMutations in alpha-synuclein and leucine-rich repeat kinase 2 (LRRK2) have been implicated in the cause of Parkinson’s disease (PD).
Nguyen, Andrew Huy
core +1 more source
Electrical Stimulation: A Potential Neuroprotective Factor for Parkinson’s Disease in Primary Cortical Neurons [PDF]
Evidence indicates that alpha-synuclein is one pathological hallmark of Parkinson’s Disease. In this thesis, we used the endogenous application of wild-type and A53T alpha-synuclein pre-formed fibrils to induce synucleopathy.
Bechkos, Sophie
core +2 more sources
Evaluation of Stp2p-dependent alpha-Synuclein Toxicity in Yeast: Role of GAPDH? [PDF]
Impulse: The Premier Undergraduate Neuroscience Journal, 2006 Parkinson's disease (PD) is linked to alpha-synuclein misfolding and aggregation in the substantia nigra par compacta cells of the brain. Discovering and characterizing factors that regulate alpha-synuclein misfolding and toxicity have high therapeutic ...
Arun George Paul
doaj