Results 31 to 40 of about 1,144,970 (369)

Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells [PDF]

Neuroscience Letters, 2008
Alpha-synuclein (alpha-syn) is implicated in the pathogenesis of Parkinson's disease (PD). Mutations in alpha-syn gene or alpha-syn locus (SNCA) triplication are associated with mitochondrial abnormalities and early onset of familial PD. The goals of the present study were to examine whether alpha-syn is localized in the mitochondria of alpha-syn ...
Manuchair Ebadi, James E. Porter, Shaik Shavali, Holly M. Brown-Borg   +3 more
openaire   +3 more sources

Preanalytical Stability of CSF Total and Oligomeric Alpha-Synuclein

Frontiers in Aging Neuroscience, 2021
Background: The role of cerebrospinal fluid (CSF) alpha-synuclein as a potential biomarker has been challenged mainly due to variable preanalytical measures between laboratories.
Ilham Y. Abdi, Nour K. Majbour, Eline A. J. Willemse, Wilma D. J. van de Berg, Brit Mollenhauer, Brit Mollenhauer, Charlotte E. Teunissen, Omar M. El-Agnaf   +7 more
doaj   +1 more source

Alpha-Synuclein: Mechanisms of Release and Pathology Progression in Synucleinopathies

Cells, 2021
The accumulation of misfolded alpha-synuclein (aSyn) throughout the brain, as Lewy pathology, is a phenomenon central to Parkinson’s disease (PD) pathogenesis.
I. C. Brás, T. Outeiro
semanticscholar   +1 more source

Gastrointestinal Immunity and Alpha-Synuclein [PDF]

Journal of Parkinson’s Disease, 2019
The gastrointestinal (GI) tract is equipped with robust immune defenses which protect the organism from infection. Enteric nerves are front and center in this defensive network, even in the most primitive organisms. Neuropeptides exhibit potent antimicrobial activity in the vicinity of the nerve and attract the innate and adaptive immune systems to ...
Michael Zasloff, Ethan D. Stolzenberg, Denise Barbut   +2 more
openaire   +2 more sources

Formation of toxic oligomeric alpha-synuclein species in living cells. [PDF]

PLoS ONE, 2008
Misfolding, oligomerization, and fibrillization of alpha-synuclein are thought to be central events in the onset and progression of Parkinson's disease (PD) and related disorders.
Tiago Fleming Outeiro, Preeti Putcha, Julie E Tetzlaff, Robert Spoelgen, Mirjam Koker, Filipe Carvalho, Bradley T Hyman, Pamela J McLean   +7 more
doaj   +1 more source

Alpha-synuclein seeds in olfactory mucosa of patients with isolated REM sleep behaviour disorder.

Brain : a journal of neurology, 2021
Isolated REM sleep behaviour disorder (RBD) is an early-stage α-synucleinopathy in most, if not all, affected subjects. Detection of pathological α-synuclein in peripheral tissues of patients with isolated RBD may identify those progressing to Parkinson ...
A. Stefani, Á. Iranzo, E. Holzknecht, D. Perra, M. Bongianni, C. Gaig, B. Heim, M. Serradell, Luca Sacchetto, Alicia Garrido, S. Capaldi, A. Sánchez-Gómez, M. P. Cecchini, S. Mariotto, S. Ferrari, M. Fiorini, J. Schmutzhard, P. Cocchiara, I. Vilaseca, Lorenzo Brozzetti, S. Monaco, M. José Martí, K. Seppi, E. Tolosa, J. Santamaria, B. Högl, W. Poewe, G. Zanusso   +27 more
semanticscholar   +1 more source

Nitrated alpha-synuclein induces the loss of dopaminergic neurons in the substantia nigra of rats. [PDF]

PLoS ONE, 2010
BACKGROUND: The pathology of Parkinson's disease (PD) is characterized by the degeneration of the nigrostriatal dopaminergic pathway, as well as the formation of intraneuronal inclusions known as Lewy bodies and Lewy neurites in the substantia nigra ...
Zhongwang Yu, Xiaohui Xu, Zhenghua Xiang, Jianfeng Zhou, Zhaohuan Zhang, Chun Hu, Cheng He   +6 more
doaj   +1 more source

Alpha‐Synuclein Oligomers and Neurofilament Light Chain Predict Phenoconversion of Pure Autonomic Failure

Annals of Neurology, 2021
To explore the role of alpha‐synuclein (αSyn) oligomers and neurofilament light chain (NfL) in cerebrospinal fluid (CSF) of patients with pure autonomic failure (PAF) as markers of future phenoconversion to multiple system atrophy (MSA).
W. Singer, A. Schmeichel, M. Shahnawaz, J. Schmelzer, D. Sletten, T. Gehrking, Jade A. Gehrking, A. D. Olson, Mariana D. Suarez, Pinaki Misra, C. Soto, P. Low   +11 more
semanticscholar   +1 more source

Alpha-synuclein aggregates are phosphatase resistant

Acta Neuropathologica Communications, 2023
AbstractAlpha-synuclein (αsyn) is an intrinsically disordered protein that aggregates in the brain in several neurodegenerative diseases collectively called synucleinopathies. Phosphorylation of αsyn at serine 129 (PSER129) was considered rare in the healthy human brain but is enriched in pathological αsyn aggregates and is used as a specific marker ...
SG Choi, T. Tittle, D. Garcia-Prada, JH Kordower, R Melki, BA Killinger   +5 more
openaire   +5 more sources

Alpha-Synuclein and Lipids: The Elephant in the Room? [PDF]

Cells, 2021
Since the initial identification of alpha-synuclein (α-syn) at the synapse, numerous studies demonstrated that α-syn is a key player in the etiology of Parkinson’s disease (PD) and other synucleinopathies. Recent advances underline interactions between α-syn and lipids that also participate in α-syn misfolding and aggregation.
Alessia Sarchione, Antoine Marchand, Jean-Marc Taymans, Marie-Christine Chartier-Harlin   +3 more
openaire   +4 more sources