Results 41 to 50 of about 59,298 (179)

Aggregated Alpha-Synuclein Transfer Efficiently between Cultured Human Neuron-Like Cells and Localize to Lysosomes. [PDF]

PLoS ONE, 2016
Parkinson's disease and other alpha-synucleinopathies are progressive neurodegenerative diseases characterized by aggregates of misfolded alpha-synuclein spreading throughout the brain. Recent evidence suggests that the pathological progression is likely
Jakob Domert, Christopher Sackmann, Emelie Severinsson, Lotta Agholme, Joakim Bergström, Martin Ingelsson, Martin Hallbeck   +6 more
doaj   +1 more source

Small Molecule Fisetin Modulates Alpha–Synuclein Aggregation

Molecules, 2021
Phenolic compounds are thought to be important to prevent neurodegenerative diseases (ND). Parkinson’s Disease (PD) is a neurodegenerative disorder known for its typical motor features, the deposition of α-synuclein (αsyn)-positive inclusions in the ...
Rita Rosado-Ramos, Joana Godinho-Pereira, Daniela Marques, Inês Figueira, Tiago Fleming Outeiro, Regina Menezes, Cláudia Nunes dos Santos   +6 more
doaj   +1 more source

The potential role of dietary polyphenols in Parkinson’s disease [PDF]

, 2011
Cumulative evidence now suggests that the abnormal aggregation of the neuronal protein alpha-synuclein is critically involved in the pathogenesis of synucleinopathies, of which Parkinson’s disease (PD) is the most prevalent. Development of neuropathology
Caruana, Mario, Vassallo, Neville
core  

Glial activation precedes alpha-synuclein pathology in a mouse model of Parkinson's disease [PDF]

, 2021
Neuroinflammation is increasingly recognized as an important feature in the pathogenesis of Parkinson's disease (PD). However, it remains unclear whether neuroinflammation contributes to nigral degeneration in PD or is merely a secondary marker of ...
Alvarez-Erviti, L, Blesa, J, Cooper, JM, Izco, M, Verona, G   +4 more
core  

Phosphorylation does not prompt, nor prevent, the formation of α-synuclein toxic species in a rat model of Parkinson's disease [PDF]

, 2017
Phosphorylation is involved in numerous neurodegenerative diseases. In particular, alpha-synuclein is extensively phosphorylated in aggregates in patients suffering from synucleinopathies.
Abbas-Terki, Toufik, Aebischer, Patrick, Azeredo da Silveira, Samareh, Cifuentes-Diaz, Carmen, Iwatsubo, Takeshi, Sage, Daniel, Schneider, Bernard L., Unser, Michaël   +7 more
core  

Direct detection of alpha synuclein oligomers in vivo [PDF]

, 2013
Background Rat models of Parkinson’s disease are widely used to elucidate the mechanisms underlying disease etiology or to investigate therapeutic approaches.
Bradley T Hyman, Darius Ebrahimi-Fakhari, Hemi Dimant, Laura Kibuuka, Liya N Zhu, Lorraine V Kalia, Nikolaus R McFarland, Pamela J McLean, Suneil K Kalia, Zhanyun Fan   +9 more
core   +1 more source

Rational design of structure‐based vaccines targeting misfolded alpha‐synuclein conformers of Parkinson's disease and related disorders

Bioengineering & Translational Medicine
Synucleinopathies, including Parkinson's disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DLB), are neurodegenerative disorders caused by the accumulation of misfolded alpha‐synuclein protein.
Jose Miguel Flores‐Fernandez, Verena Pesch, Aishwarya Sriraman, Enrique Chimal‐Juarez, Sara Amidian, Xiongyao Wang, Caleb Duckering, Andrew Fang, Sara Reithofer, Liang Ma, Leonardo M. Cortez, Valerie L. Sim, Gültekin Tamgüney, Holger Wille   +13 more
doaj   +1 more source

Anti-α-synuclein c-terminal antibodies block PFF uptake and accumulation of phospho-synuclein in preclinical models of Parkinson's disease

Neurobiology of Disease, 2023
Parkinson's disease (PD), a neurodegenerative disease affecting dopaminergic (DA) neurons, is characterized by decline of motor function and cognition. Dopaminergic cell loss is associated with accumulation of toxic alpha synuclein aggregates.
Robert Brendza, Xiaoying Gao, Kimberly L. Stark, Han Lin, Seung-Hye Lee, Changyun Hu, Hao Cai, Danielle DiCara, Yi-Chun Hsiao, Hai Ngu, Oded Foreman, Miriam Baca, Monika Dohse, Jean-Phillipe Fortin, Racquel Corpuz, Dhaya Seshasayee, Amy Easton, Gai Ayalon, Isidro Hötzel, Ben Chih   +19 more
doaj  

Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human alpha-synuclein in transgenic mouse brain. [PDF]

, 2009
Alpha-synuclein (SNCA) gene has been implicated in the development of rare forms of familial Parkinson disease (PD). Recently, it was shown that an increase in SNCA copy numbers leads to elevated levels of wild-type SNCA-mRNA and protein and is ...
Bernard, David J, Chiba-Falek, Ornit, Cronin, Kenneth D, El-Agnaf, Omar MA, Ge, Dongliang, Linnertz, Colton, Manninger, Paul, Nussbaum, Robert L, Orrison, Bonnie M, Rossoshek, Anna, Schlossmacher, Michael G   +10 more
core   +2 more sources

A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice [PDF]

, 2010
BACKGROUND: Parkinson's disease (PD), the second most frequent neurodegenerative disorder at old age, can be caused by elevated expression or the A53T missense mutation of the presynaptic protein alpha-synuclein (SNCA). PD is characterized pathologically
Auburger, Georg, Bockhart, Vanessa, Bonin, Michael, Calabresi, Paolo, Double, Kay L., Fernández-Ruiz, Javier, García-Arencibia, Moisés, Gerlach, Manfred, Gispert, Suzana, Kurz, Alexander, Lastres-Becker, Isabel, Liss, Birgit, Lüddens, Hartmut, Nuber, Silke, Schlaudraff, Falk, Tantucci, Michela, Tozzi, Alessandro, Wüllner, Ullrich   +17 more
core   +1 more source