Results 41 to 50 of about 1,144,970 (369)

Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy. [PDF]

PLoS ONE, 2009
In synucleinopathies, including Parkinson's disease, partially ubiquitylated alpha-synuclein species phosphorylated on serine 129 (P(S129)-alpha-synuclein) accumulate abnormally.
Margot Fournier, Jérémie Vitte, Jérôme Garrigue, Dominique Langui, Jean-Philippe Dullin, Françoise Saurini, Naïma Hanoun, Fernando Perez-Diaz, Fabien Cornilleau, Chantal Joubert, Héctor Ardila-Osorio, Sabine Traver, René Duchateau, Cécile Goujet-Zalc, Katerina Paleologou, Hilal A Lashuel, Christian Haass, Charles Duyckaerts, Charles Cohen-Salmon, Philipp J Kahle, Michel Hamon, Alexis Brice, Olga Corti   +22 more
doaj   +1 more source

Diagnostic value of cerebrospinal fluid alpha-synuclein seed quantification in synucleinopathies

Brain : a journal of neurology, 2021
Several studies have confirmed the α-synuclein real-time quaking-induced conversion (RT-QuIC) assay to have high sensitivity and specificity for Parkinson’s disease.
I. Poggiolini, Vandana Gupta, M. Lawton, S. Lee, A. El-Turabi, Agustín Querejeta-Coma, C. Trenkwalder, F. Sixel-Döring, A. Foubert-Samier, A. Pavy-Le Traon, G. Plazzi, F. Biscarini, J. Montplaisir, J. Gagnon, R. Postuma, E. Antelmi, W. Meissner, B. Mollenhauer, Y. Ben-Shlomo, M. Hu, L. Parkkinen   +20 more
semanticscholar   +1 more source

Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease

npj Parkinson's Disease, 2021
With the advent of the genetic era in Parkinson’s disease (PD) research in 1997, α-synuclein was identified as an important player in a complex neurodegenerative disease that affects >10 million people worldwide. PD has been estimated to have an economic
L. M. Oliveira, T. Gasser, R. Edwards, M. Zweckstetter, R. Melki, L. Stefanis, H. Lashuel, D. Sulzer, K. Vekrellis, G. Halliday, J. Tomlinson, M. Schlossmacher, P. Jensen, Julia M. Schulze-Hentrich, O. Riess, W. Hirst, O. El‐Agnaf, B. Mollenhauer, Peter Lansbury, T. Outeiro   +19 more
semanticscholar   +1 more source

Alpha-synuclein spreading in Parkinson’s disease [PDF]

Frontiers in Neuroanatomy, 2014
Formation and accumulation of misfolded protein aggregates are a central hallmark of several neurodegenerative diseases. In Parkinson's disease (PD), the aggregation-prone protein alpha-synuclein (α-syn) is the culprit. In the past few years, another piece of the puzzle has been added with data suggesting that α-syn may self-propagate, thereby ...
Recasens, Ariadna, Dehay, Benjamin
openaire   +4 more sources

Anti-α-synuclein c-terminal antibodies block PFF uptake and accumulation of phospho-synuclein in preclinical models of Parkinson's disease

Neurobiology of Disease, 2023
Parkinson's disease (PD), a neurodegenerative disease affecting dopaminergic (DA) neurons, is characterized by decline of motor function and cognition. Dopaminergic cell loss is associated with accumulation of toxic alpha synuclein aggregates.
Robert Brendza, Xiaoying Gao, Kimberly L. Stark, Han Lin, Seung-Hye Lee, Changyun Hu, Hao Cai, Danielle DiCara, Yi-Chun Hsiao, Hai Ngu, Oded Foreman, Miriam Baca, Monika Dohse, Jean-Phillipe Fortin, Racquel Corpuz, Dhaya Seshasayee, Amy Easton, Gai Ayalon, Isidro Hötzel, Ben Chih   +19 more
doaj   +1 more source

Modeling Parkinson’s Disease With the Alpha-Synuclein Protein

Frontiers in Pharmacology, 2020
Alpha-synuclein (α-Syn) is a key protein involved in Parkinson's disease (PD) pathology. PD is characterized by the loss of dopaminergic neuronal cells in the substantia nigra pars compacta and the abnormal accumulation and aggregation of α-Syn in the ...
Mónica Gómez-Benito, N. Granado, Patricia García-Sanz, A. Michel, M. Dumoulin, R. Moratalla   +5 more
semanticscholar   +1 more source

Transcriptional regulation of the beta-synuclein 5'-promoter metal response element by metal transcription factor-1. [PDF]

PLoS ONE, 2011
The progression of many human neurodegenerative disorders is associated with an accumulation of alpha-synuclein. Alpha-synuclein belongs to the homologous synuclein family, which includes beta-synuclein.
Patrick C McHugh, Josephine A Wright, David R Brown   +2 more
doaj   +1 more source

Alpha-Synuclein as a Biomarker of Parkinson’s Disease: Good, but Not Good Enough

Frontiers in Aging Neuroscience, 2021
Parkinson’s disease (PD) is the second most common neurodegenerative disorder of the elderly, presenting primarily with symptoms of motor impairment.
Upasana Ganguly, Sukh Singh, Soumya Pal, Suvarna Prasad, B. Agrawal, R. Saini, S. Chakrabarti   +6 more
semanticscholar   +1 more source

Targeted Extracellular Vesicle Gene Therapy for Modulating Alpha-Synuclein Expression in Gut and Spinal Cord

Pharmaceutics, 2023
The development of effective disease-modifying therapies to halt Parkinson’s disease (PD) progression is required. In a subtype of PD patients, alpha-synuclein pathology may start in the enteric nervous system (ENS) or autonomic peripheral nervous system.
Maria Izco, Martin Schleef, Marco Schmeer, Estefania Carlos, Guglielmo Verona, Lydia Alvarez-Erviti   +5 more
doaj   +1 more source

p27Kip1 regulates alpha-synuclein expression [PDF]

Oncotarget, 2018
Alpha-synuclein (α-SYN) is the main component of anomalous protein aggregates (Lewy bodies) that play a crucial role in several neurodegenerative diseases (synucleinopathies) like Parkinson's disease and multiple system atrophy. However, the mechanisms involved in its transcriptional regulation are poorly understood.
Gallastegui Calvache, Edurne, 1982-, Domuro, Carla, Serratosa i Serdà, Joan, Larrieux, Alejandra, Sin, Laura, Martínez, Jonatan, Besson, Arnaud, Morante Redolat, José Manuel, Orlando, Serena, Aligué i Alemany, Rosa Maria, Fariñas, Isabel, Pujol Sobrevía, María Jesús, Bachs Valldeneu, Oriol   +12 more
openaire   +5 more sources