Results 51 to 60 of about 1,144,970 (369)

Alpha-synuclein levels in blood plasma decline with healthy aging. [PDF]

PLoS ONE, 2015
There is unequivocal evidence that alpha-synuclein plays a pivotal pathophysiological role in neurodegenerative diseases, and in particular in synucleinopathies.
Niklas K U Koehler, Elke Stransky, Mirjam Meyer, Susanne Gaertner, Mona Shing, Martina Schnaidt, Maria S Celej, Thomas M Jovin, Thomas Leyhe, Christoph Laske, Anil Batra, Gerhard Buchkremer, Andreas J Fallgatter, Dorothee Wernet, Elke Richartz-Salzburger   +14 more
doaj   +1 more source

Polymorphism of Alpha-Synuclein Amyloid Fibrils Depends on Ionic Strength and Protein Concentration

International Journal of Molecular Sciences, 2021
Protein aggregate formation is linked with multiple amyloidoses, including Alzheimer‘s and Parkinson‘s diseases. Currently, the understanding of such fibrillar structure formation and propagation is still not sufficient, the outcome of which is a lack of
Mantas Žiaunys, A. Sakalauskas, Kamile Mikalauskaite, V. Smirnovas   +3 more
semanticscholar   +1 more source

Direct detection of alpha synuclein oligomers in vivo [PDF]

, 2014
Background: Rat models of Parkinson’s disease are widely used to elucidate the mechanisms underlying disease etiology or to investigate therapeutic approaches.
Dimant, Hemi, Ebrahimi-Fakhari, Darius, Fan, Zhanyun, Hyman, Bradley T, Kalia, Lorraine V, Kalia, Suneil K, Kibuuka, Laura, McFarland, Nikolaus R, McLean, Pamela J, Zhu, Liya N   +9 more
core   +1 more source

Alpha-Synuclein Interactions with Membranes [PDF]

, 2011
Synucleinopathies are a group of neurodegenerative disorders that share common pathological intracellular deposits that contain aggregates of the protein ┙-synuclein. Substantial evidence suggests that fibril formation by ┙-synuclein is a critical step in the development of Parkinson's disease (PD).
Pirc, Katja, Poklar Ulrih, Nataša
openaire   +4 more sources

Differentially targeted seeding reveals unique pathological alpha-synuclein propagation patterns

Brain : a journal of neurology, 2021
Parkinson’s disease is a progressive neurodegenerative disorder characterized by the intracellular accumulation of insoluble alpha-synuclein aggregates into Lewy bodies and neurites.
S. Rahayel, B. Mišić, Ying-Qiu Zheng, Zhen-Qi Liu, A. Abdelgawad, N. Abbasi, Anna Caputo, Bin Zhang, Angela Lo, Victoria M. Kehm, Michael Kozak, Han Soo Yoo, A. Dagher, Kelvin C. Luk   +13 more
semanticscholar   +1 more source

Lipid peroxidation is essential for α-synuclein-induced cell death. [PDF]

, 2015
Parkinson's disease is the second most common neurodegenerative disease and its pathogenesis is closely associated with oxidative stress. Deposition of aggregated α-synuclein (α-Syn) occurs in familial and sporadic forms of Parkinson's disease.
Abramov, AY, Angelova, PR, Gandhi, S, Horrocks, MH, Klenerman, D, Shchepinov, MS   +5 more
core   +2 more sources

The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen [PDF]

, 2011
Increased brain α-synuclein (SNCA) protein expression resulting from gene duplication and triplication can cause a familial form of Parkinson's disease (PD).
Bandyopadhyay, Sanghamitra, Cahill, Catherine M., Castelvetri, Ippolita Cantuti, Greig, Nigel H., Huang, Xudong, Lahiri, Debomoy K., Maccecchini, Maria L., Mikkilineni, Sohan, Rogers, Jack T., Smith, Deborah H.   +9 more
core   +1 more source

High-Affinity Detection of Alpha-Synuclein by Aptamer-Gold Conjugates on an Amine-Modified Dielectric Surface

Journal of Analytical Methods in Chemistry, 2019
Parkinson’s disease (PD) is a progressive health issue and influences an increasingly larger number of people, especially at older ages, affecting the central nervous system (CNS).
Xuemei You, Subash C. B. Gopinath, Thangavel Lakshmipriya, Dingan Li   +3 more
doaj   +1 more source

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

Neurobiology of Disease, 2011
Alpha-synuclein aggregation plays a central role in Parkinson's disease pathology. Direct transmission of alpha-synuclein from pathologically affected to healthy unaffected neurons may be important in the anatomical spread of the disease through the ...
Lydia Alvarez-Erviti, Yiqi Seow, Anthony H. Schapira, Chris Gardiner, Ian L. Sargent, Matthew J.A. Wood, J. Mark Cooper   +6 more
doaj   +1 more source

Intercellular transmission of alpha-synuclein. [PDF]

Front Mol Neurosci
An emerging theme in Parkinson’s disease (PD) is the propagation of α-synuclein pathology as the disease progresses. Research involving the injection of preformed α-synuclein fibrils (PFFs) in animal models has recapitulated the pathological spread observed in PD patients.
Wu S, Schekman RW.
europepmc   +6 more sources