Results 51 to 60 of about 59,298 (179)
Frontiers in Aging Neuroscience, 2020 Parkinson’s disease (PD) is a debilitating neurodegenerative disorder defined by a loss of dopamine-producing neurons in the substantia nigra in the brain. It is associated with cytosolic inclusions known as Lewy bodies.
Sarah M. Hernandez +2 more
doaj +1 more source
Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type. [PDF]
, 2017 Amyloid aggregates found in the brain of patients with neurodegenerative diseases, including Alzheimer's and Parkinson's disease, are thought to spread to increasingly larger areas of the brain through a prion-like seeding mechanism.
Esko, Jeffrey D +5 more
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Select polyphenols protect mitochondria against amyloid aggregates in Alzheimer and Parkinson diseases [PDF]
, 2014 Alzheimer and Parkinson diseases are age-related neurodegenerative disorders in which formation of amyloid aggregates by amyloid-beta (Abeta) and α-synuclein (αS) proteins, respectively, are recognised critical events that occur early in the disease ...
Caruana, Mario, Vassallo, Neville
core +1 more source
Frontiers in Neuroscience, 2019 Accumulation and aggregation of misfolded alpha-synuclein is believed to be a cause of Parkinson’s disease (PD). Phosphorylation of alpha-synuclein at S129 is known to be associated with the pathological misfolding process, but efforts to investigate the
Cristina Cariulo +15 more
doaj +1 more source
Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson\xe2\x80\x99s disease [PDF]
, 2018 The involvement of DNA damage and repair in aging processes is well established. Aging is an unequivocal risk factor for chronic neurodegenerative diseases, underscoring the relevance of investigations into the role that DNA alterations may have in the ...
Blandini, F. (Fabio) +9 more
core +3 more sources
Characterization of a Split-Nluc Assay for Monitoring Changes in Alpha-Synuclein Solubility in Living Cells [PDF]
, 2020 Alpha-synuclein is the primary constituent of Lewy Bodies, protein aggregates associated with Parkinson’s Disease, Dementia with Lewy Bodies, and Multiple Systems Dystrophy. Given the terminal nature of these synucleinopathies, the need for an assay that
Truong, BaoLong
core +1 more source
Deletion of alpha-synuclein decreases impulsivity in mice [PDF]
, 2012 The presynaptic protein alpha-synuclein, associated with Parkinson's Disease (PD), plays a role in dopaminergic neurotransmission and is implicated in impulse control disorders (ICDs) such as drug addiction.
Buchman, V L +7 more
core +2 more sources
F1000Research, 2014 The accumulation of misfolded a-synuclein is mechanistically linked to neurodegeneration in Parkinson’s disease (PD) and other alpha-synucleinopathies. However, how alpha-synuclein causes neurodegeneration is unresolved.
Yan Liu +5 more
doaj +1 more source
Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission
Neurobiology of Disease, 2011 Alpha-synuclein aggregation plays a central role in Parkinson's disease pathology. Direct transmission of alpha-synuclein from pathologically affected to healthy unaffected neurons may be important in the anatomical spread of the disease through the ...
Lydia Alvarez-Erviti +6 more
doaj
Contribution of syndecans to cellular uptake and fibrillation of alpha-synuclein and tau [PDF]
, 2019 Scientific evidence suggests that alpha-synuclein and tau have prion-like properties and that prionlike spreading and seeding of misfolded protein aggregates constitutes a central mechanism for neurodegeneration.
Domonkos, Ildikó +6 more
core +1 more source