Results 81 to 90 of about 5,528 (200)
Comprehensive view of macrophage autophagy and its application in cardiovascular diseases
Cell Proliferation, Volume 57, Issue 1, January 2024.This review systematically describes the role of autophagy in macrophage functions, highlighting the existing evidence in the regulation of inflammation, cell death, metabolism, phagocytosis, and so forth. Meanwhile, we summarize the latest progress of therapeutics targeting macrophage autophagy in cardiovascular diseases, hoping to provide novel ...
Wanqian Pan +10 more
wiley +1 more source
Calcineurin Suppression of Alpha7 nAChR Currents in Xenopus Oocytes [PDF]
Biophysical Journal, 2010 As part of our study of mechanisms underlying upregulation of neuronal nicotinic acetylcholine receptors (nAChRs) in brain, due to chronic nicotine exposure, we are characterizing signaling pathways that influence the magnitude of α7 nAChR currents in Xenopus oocytes. In previous studies of Kv1.1 channels in oocytes, we found that calcineurin (CaN) and
Farley, Joseph +6 more
openaire +1 more source
The role of alpha-7 nicotinic receptors in food intake behaviors
Frontiers in Psychology, 2014 Nicotine alters appetite and energy expenditure, leading to changes in body weight. While the exact mechanisms underlying these effects are not fully established, both central and peripheral involvement of the alpha-7 nicotinic acetylcholine receptor ...
Kristina L. McFadden +3 more
doaj +1 more source
Voltage- and temperature-dependent allosteric modulation of alpha7 nicotinic receptors by PNU120596
Frontiers in Pharmacology, 2011 Alpha7 nicotinic receptors (a7nAChR) are widely distributed throughout the central nervous system (CNS) and are found at particularly high levels in the hippocampus and cortex.
Fabrio eSitzia +3 more
doaj +1 more source
Novel Insights for Systemic Inflammation in Sepsis and Hemorrhage
Mediators of Inflammation, 2010 The inflammatory responses in sepsis and hemorrhage remain a major cause of death. Clinically, it is generally accepted that shock in sepsis or hemorrhage differs in its mechanisms.
Bolin Cai, Edwin A. Deitch, Luis Ulloa
doaj +1 more source
Identification of 5 beta-cholestane-3 alpha,7 alpha,12 alpha,24,25,26-hexol in human urine
Journal of Lipid Research, 1987 A new bile alcohol, 5 beta-cholestanehexol, was identified in the urine of healthy humans as the glucuronide. The bile alcohol glucuronide fraction was isolated by an ion exchange chromatography on piperidinohydroxypropyl Sephadex LH-20.
T Hiraoka +4 more
doaj +1 more source
European Journal of Histochemistry, 2020 Adipose-derived stem cells (ASCs) are an attractive source for regenerative medicine as they can be easily isolated, rapidly expandable in culture and show excellent in vitro differentiation potential.
Marta Pernarella +8 more
doaj +1 more source
Stoichiometry for activation of neuronal alpha7 nicotinic receptors
, 2013 Neuronal α7 nicotinic receptors elicit rapid cation influx in response to acetylcholine (ACh) or its hydrolysis product choline. They contribute to cognition, synaptic plasticity, and neuroprotection and have been implicated in neurodegenerative and neuropsychiatric disorders. α7, however, often localizes distal to sites of nerve-released ACh and binds
Andersen, Natalia Denise +3 more
openaire +2 more sources
Downregulation of alpha7 nicotinic acetylcholine receptor in two-kidney one-clip hypertensive rats
BMC Cardiovascular Disorders, 2012 Background Inflammation processes are important participants in the pathophysiology of hypertension and cardiovascular diseases. The role of the alpha7 nicotinic acetylcholine receptor (α7nAChR) in inflammation has recently been identified.
Chen Ji-Kuai +5 more
doaj +1 more source
Neuronal and Glial α7 Nicotinic Acetylcholine Receptors: Role in Alzheimer’s Disease Pathophysiology
LifeCholinergic projections from the basal forebrain to the cortex and hippocampus play a critical role in cognitive functions, many of which rely on signaling through the alpha7 nicotinic acetylcholine receptor (α7nAChR).
Kerry Rennie
doaj +1 more source