Results 121 to 130 of about 2,375 (163)

Functional deletion of α7 nicotinic acetylcholine receptor impairs Ca²⁺-dependent glutamatergic synaptic transmission by affecting both presynaptic and postsynaptic protein expression and function. [PDF]

Front Physiol
Cannata B, Sposito L, Albini M, Aceto G, Puliatti G, Lazzarino G, Ripoli C, Tropea MR, Puzzo D, Piacentini R, Grassi C.   +10 more
europepmc   +1 more source

Effects of Swapping 5HT3 and α7 Residues in Chimeric Receptor Proteins on RIC3 and NACHO Chaperone Actions. [PDF]

Molecules
Yan Z, Oruganti S, Iyer SK, Agarwal K, Gupta M, Adhikari K, Vijayan N, Doda J, Jain V, Lokhande AN, Nair AP, Nallanichakravarthula VSK, Weltzin MM, Loring RH.   +13 more
europepmc   +1 more source

Assessment of [¹²⁵I]a-Bungarotoxin Binding to a7 Nicotinic Acetylcholinergic Receptors in Hippocampus-Subiculum of Postmortem Human Parkinson's Disease Brain. [PDF]

Biomolecules
Karim F, Ngo A, Tucker TE, Coronel ADL, Mukherjee J.   +4 more
europepmc   +1 more source

Computational model of alpha 7 nicotinic acetylcholine receptor in thalamic reticular nucleus neurons and their involvement in network states. [PDF]

PLoS One
Ullah A, Therrien K, Cressman JR, Kabbani N.   +3 more
europepmc   +1 more source

Nicotine affects tight junction barriers via alpha7 nicotine-like acetylcholine receptor in keratinocytes.

Nicotine affects tight junction barriers via alpha7 nicotine-like acetylcholine receptor in keratinocytes.
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Targeting the nicotinic alpha7 acetylcholine receptor to enhance cognition in disease

Biochemical Pharmacology, 2011
A promising drug target currently under investigation to improve cognitive deficits in neuropsychiatric and neurological disorders is the neuronal nicotinic alpha7 acetylcholine receptor (α7nAChR). Improving cognitive impairments in diseases such as Alzheimer's (AD) and schizophrenia remains a large unmet medical need, and the α7nAChR has many ...
Tanya L, Wallace, Richard H P, Porter
openaire   +4 more sources

Characterization of compounds on nicotinic acetylcholine receptor alpha7 channels using higher throughput electrophysiology

Journal of Neuroscience Methods, 2009
Alpha7 nicotinic acetylcholine receptor channels are important ligand-gated ion channels that are fast desensitizing, cation selective and have been implicated in the pathophysiology of schizophrenia and Alzheimer's disease. We report here high quality alpha7 parallel patch clamp recordings using the QPatch automated patch clamp system.
S, Friis, C, Mathes, M, Sunesen, M R, Bowlby, J, Dunlop   +4 more
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Alpha7 nicotinic acetylcholine receptor expression in Sorafenib-resistant Hepatocellular carcinoma cells

Medical Oncology, 2022
Hepatocellular carcinoma (HCC), the most prevalent kind of liver cancer, remains one of the world's main causes of death. The alpha7 nicotinic acetylcholine receptor (α7nAchR) has been recognized to be overexpressed in malignancies and chemoresistance.
Mina Afrashteh Nour, Fatemeh Kheradmand, Yousef Rasmi, Behzad Baradaran   +3 more
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Aryloxyethylamines: Binding at α7 nicotinic acetylcholine receptors

Bioorganic & Medicinal Chemistry Letters, 2006
Structure-affinity relationships for the binding of 3-[2-(N,N,N-trimethylammonium)ethoxy]pyridine (AXPQ) at alpha7 nACh receptors were investigated due to its close structural similarity to a known alpha7 antagonist.
Hanan M, Ragab, Jin Sung, Kim, Małgorzata, Dukat, Hernán, Navarro, Richard A, Glennon   +4 more
openaire   +2 more sources

The α7 nicotinic acetylcholine receptor in neuronal plasticity

Molecular Neurobiology, 1999
A growing body of evidence indicates that neuronal nicotinic acetylcholine receptors (nAChRs), in addition to promoting fast cholinergic transmission, may modulate other neuronal activities within the central nervous system (CNS). In particular, the alpha7 nAChR is highly permeable to Ca2+ and may serve a distinct role in regulating neuronal plasticity.
R S, Broide, F M, Leslie
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