Results 21 to 30 of about 2,375 (163)

Upregulation of alpha7 Nicotinic Receptors by Acetylcholinesterase C-Terminal Peptides. [PDF]

PLoS ONE, 2009
BACKGROUND: The alpha-7 nicotinic acetylcholine receptor (alpha7-nAChR) is well known as a potent calcium ionophore that, in the brain, has been implicated in excitotoxicity and hence in the underlying mechanisms of neurodegenerative disorders such as ...
Cherie E Bond, Martina Zimmermann, Susan A Greenfield   +2 more
doaj   +1 more source

[11C]CHIBA-1001 as a novel PET ligand for alpha7 nicotinic receptors in the brain: a PET study in conscious monkeys. [PDF]

PLoS ONE, 2008
BackgroundThe alpha7 nicotinic acetylcholine receptors (nAChRs) play an important role in the pathophysiology of neuropsychiatric diseases such as schizophrenia and Alzheimer's disease.
Kenji Hashimoto, Shingo Nishiyama, Hiroyuki Ohba, Masaaki Matsuo, Tatsuhiko Kobashi, Makoto Takahagi, Masaomi Iyo, Takeru Kitashoji, Hideo Tsukada   +8 more
doaj   +1 more source

Targeted molecular dynamics study of C-loop closure and channel gating in nicotinic receptors. [PDF]

PLoS Computational Biology, 2006
The initial coupling between ligand binding and channel gating in the human alpha7 nicotinic acetylcholine receptor (nAChR) has been investigated with targeted molecular dynamics (TMD) simulation. During the simulation, eight residues at the tip of the C-
Xiaolin Cheng, Hailong Wang, Barry Grant, Steven M Sine, J Andrew McCammon   +4 more
doaj   +1 more source

Alpha7 nicotinic acetylcholine receptor: A link between inflammation and neurodegeneration [PDF]

Neuroscience & Biobehavioral Reviews, 2008
Alzheimer's disease (AD) is the leading cause of dementia affecting over 25 million people worldwide. Classical studies focused on the description and characterization of the pathological hallmarks found in AD patients including the neurofibrillary tangles and the amyloid plaques.
Concepcion, Conejero-Goldberg, Peter, Davies, Luis, Ulloa   +2 more
openaire   +2 more sources

Age-Associated Tooth Loss and Oral Microbial Dysbiosis in a Mouse Genetic Model of Chronic Nicotine Exposure

Frontiers in Immunology, 2020
Nicotine acts as a potent modulator of normal cellular responses through the nicotinic acetylcholine receptor subtype alpha7. In a mouse genetic model of alpha7 receptor dysfunction, alpha7E260A:G, 85 percent of 18 month-old mice exhibit an age ...
Scott W. Rogers, Scott W. Rogers, Elizabeth J. Myers, Lorise C. Gahring, Lorise C. Gahring   +4 more
doaj   +1 more source

Cholinergic pairing with visual activation results in long-term enhancement of visual evoked potentials. [PDF]

PLoS ONE, 2009
Acetylcholine (ACh) contributes to learning processes by modulating cortical plasticity in terms of intensity of neuronal activity and selectivity properties of cortical neurons.
Jun Il Kang, Elvire Vaucher
doaj   +1 more source

Research update: Alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease [PDF]

Biochemical Pharmacology, 2011
Aberrant amyloid-β peptide (Aβ) accumulation along with altered expression and function of nicotinic acetylcholine receptors (nAChRs) stand prominently in the etiology of Alzheimer's disease (AD). Since the discovery that Aβ is bound to α7 nAChRs under many experimental settings, including post-mortem AD brain, much effort has been expended to ...
Parri, H. Rheinallt, Hernandez, Caterina M., Dineley, Kelly T.   +2 more
openaire   +2 more sources

Nicotine acts on growth plate chondrocytes to delay skeletal growth through the alpha7 neuronal nicotinic acetylcholine receptor. [PDF]

PLoS ONE, 2008
BACKGROUND: Cigarette smoking adversely affects endochondral ossification during the course of skeletal growth. Among a plethora of cigarette chemicals, nicotine is one of the primary candidate compounds responsible for the cause of smoking-induced ...
Atsuo Kawakita, Kazuki Sato, Hatsune Makino, Hiroyasu Ikegami, Shinichiro Takayama, Yoshiaki Toyama, Akihiro Umezawa   +6 more
doaj   +1 more source

Intraspecific difference of Latilactobacillus sakei in inflammatory bowel diseases: Insights into potential mechanisms through comparative genomics and metabolomics analyses

iMeta, Volume 2, Issue 4, November 2023., 2023
We obtained 72 strains of Latilactobacillus sakei from 120 fermentation and fecal samples across China. In total, 16 strains from different sources were initially screened in an in vitro Caco‐2 model. Subsequently, six strains (four exhibiting effectiveness and two exhibiting ineffectiveness) were selected for further validation in an in vivo colitis ...
Yaru Liu, Hui Duan, Ying Chen, Chengcheng Zhang, Jianxin Zhao, Arjan Narbad, Fengwei Tian, Qixiao Zhai, Leilei Yu, Wei Chen   +9 more
wiley   +1 more source

Two residues determine nicotinic acetylcholine receptor requirement for RIC‐3

Protein Science, Volume 32, Issue 9, September 2023., 2023
Abstract Nicotinic acetylcholine receptors (N‐AChRs) mediate fast synaptic signaling and are members of the pentameric ligand‐gated ion channel (pLGIC) family. They rely on a network of accessory proteins in vivo for correct formation and transport to the cell surface.
Jennifer D. Noonan, Robin N. Beech
wiley   +1 more source