Results 81 to 90 of about 2,375 (163)

Migration of gastric cancer is suppressed by recombinant Newcastle disease virus (rL-RVG) via regulating α7-nicotinic acetylcholine receptors/ERK- EMT

BMC Cancer, 2019
Background Nicotinic acetylcholine receptors (nAChRs) have been reported to be overexpressed in malignancies in humans and is associated with tumorigenesis and cell migration. In previous studies of gastric cancer, alpha7 nicotinic acetylcholine receptor
Xuefeng Bu, Anwei Zhang, Zhengwei Chen, Xuanfeng Zhang, Riting Zhang, Chaoyun Yin, Jie Zhang, Yao Zhang, Yulan Yan   +8 more
doaj   +1 more source

Opportunities in precision psychiatry using PET neuroimaging in psychosis

Neurobiology of Disease, 2019
With the movement toward precision medicine in healthcare, recent studies of individuals with psychosis have begun to explore positron emission tomography (PET) as a tool to test for biochemical signatures that may distinguish subtypes of psychosis that ...
Jennifer M. Coughlin, Andrew G. Horti, Martin G. Pomper   +2 more
doaj   +1 more source

α7 Nicotinic acetylcholine receptor-mediated anti-inflammatory effect in a chronic migraine rat model via the attenuation of glial cell activation

Journal of Pain Research, 2018
Qing Liu,1 Chaoyang Liu,1 Li Jiang,1 Maolin Li,1 Ting Long,1 Wei He,1 Guangcheng Qin,2 Lixue Chen,2 Jiying Zhou1 1Department of Neurology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China; 2Laboratory Research Center, The ...
Liu Q, Liu C, Jiang L, Li M, Long T, He W, Qin G, Chen L, Zhou J   +8 more
doaj  

A Potential Role of Alpha-7 Nicotinic Acetylcholine Receptor in Cardiac Angiogenesis in a Pressure-Overload Rat Model

Journal of Pharmacological Sciences, 2010
.: This work investigated the expression of alpha-7 nicotinic acetylcholine receptor (α7nAChR) in the left ventricle and its putative role in cardiac angiogenesis in a pressure overload rat model induced by abdominal aorta coarctation. Blood pressure and
Min Ni, Zhong-Wei Yang, Dong-Jie Li, Quan Li, Shu-Hui Zhang, Ding-Feng Su, He-Hui Xie, Fu-Ming Shen   +7 more
doaj   +1 more source

Retinal ganglion cell neuroprotection induced by activation of alpha7 nicotinic acetylcholine receptors

Neural Regeneration Research, 2016
Glaucoma is a group of degenerative retinal diseases that damage the eye's optic nerve and can result in vision loss and blindness. It is characterized by optic neuropathy, cupping of the optic disk, and progressive loss of retinal ganglion cells (RGCs) and axons in the optic nerve.
openaire   +3 more sources

Neuroimmune Interactions in Schizophrenia: Focus on Vagus Nerve Stimulation and Activation of the Alpha-7 Nicotinic Acetylcholine Receptor

Frontiers in Immunology, 2017
Schizophrenia is one of the most debilitating mental disorders and is aggravated by the lack of efficacious treatment. Although its etiology is unclear, epidemiological studies indicate that infection and inflammation during development induces ...
Fabiana Maria das Graças Corsi-Zuelli, Fernanda Brognara, Gustavo Fernando da Silva Quirino, Carlos Hiroji Hiroki, Rafael Sobrano Fais, Cristina Marta Del-Ben, Luis Ulloa, Helio Cesar Salgado, Alexandre Kanashiro, Camila Marcelino Loureiro   +9 more
doaj   +1 more source

Stimulation of nicotinic acetylcholine alpha7 receptors rescue schizophrenia-like cognitive impairments in rats

Journal of Psychopharmacology, 2016
Alpha7 nicotinic acetylcholine receptor (α7 nAChR) dysfunction plays an important role in schizophrenia. Positive allosteric modulators of α7 nAChR have emerged as a promising therapeutic approach to manage cognitive deficits that are inadequately treated in schizophrenic patients.
Potasiewicz, Agnieszka, Nikiforuk, Agnieszka, Hołuj, Małgorzata, Popik, Piotr   +3 more
openaire   +3 more sources

α-Conotoxin ImI-modified polymeric micelles as potential nanocarriers for targeted docetaxel delivery to α7-nAChR overexpressed non-small cell lung cancer

Drug Delivery, 2018
A micelle system modified with α-Conotoxin ImI (ImI), a potently antagonist for alpha7 nicotinic acetylcholine receptor (α7-nAChR) previously utilized for targeting breast cancer, was constructed.
Dong Mei, Libo Zhao, Binlong Chen, Xiaoyan Zhang, Xiaoling Wang, Zhiying Yu, Xin Ni, Qiang Zhang   +7 more
doaj   +1 more source

Unprecedented effect of vitamin D3 on T-cell receptor beta subunit and alpha7 nicotinic acetylcholine receptor expression in a 3-nitropropionic acid induced mouse model of Huntington's disease. [PDF]

IBRO Neurosci Rep, 2023
Manjari S, Abraham SM, Poornima R, Chaturvedi RK, Maity S, Komal P.   +5 more
europepmc   +1 more source

Alpha7 Nicotinic Acetylcholine Receptor Antagonists Prevent Meningitic Escherichia coli-Induced Blood-Brain Barrier Disruptions by Targeting the CISH/JAK2/STAT5b Axis. [PDF]

Biomedicines, 2022
Gong Z, Gao X, Li Y, Zou J, Lun J, Chen J, Zhou C, He X, Cao H.   +8 more
europepmc   +1 more source