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A Meta-Analysis of Synovial Biomarkers in Periprosthetic Joint Infection: Synovasure™ Is Less Effective Than the ELISA-Based Alpha-Defensin Test [PDF]
Knee Surgery, Sports Traumatology, Arthroscopy, 2018 PURPOSE (1) To determine the overall accuracy of synovial alpha-defensin, synovial C-reactive protein (sCRP), interleukin-6 (sIL-6), and leukocyte esterase (sLE) as diagnostic markers for periprosthetic joint infection (PJI) and (2) to independantly ...
Sufian Ahmad +2 more
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The Routine Use of Synovial Alpha-Defensin Is Not Necessary
Bone and Joint Journal, 2020Aims To establish the utility of adding the laboratory-based synovial alpha-defensin immunoassay to the traditional diagnostic work-up of a prosthetic joint infection (PJI). Methods A group of four physicians evaluated 158 consecutive patients who were worked up for PJI, of which 94 underwent revision arthroplasty.
Robin Z Cheng +2 more
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A profile on the Synovasure alpha defensin test for the detection of periprosthetic infections
Expert Review of Molecular Diagnostics, 2020Clinicians have waited a long time for a 'universal' marker that may help them distinguish infected from non-infected total joint arthroplasties when doubts persist after using classical clinical and biological signs of infection. In recent years, synovial fluid biomarkers including leukocyte esterase, alpha-defensins, and CRP have shown promising ...
Senneville, Eric +5 more
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Expression of alpha‐defensin‐1 in chronic hyperplastic candidosis
Journal of Oral Pathology & Medicine, 2005Background: Chronic hyperplastic candidosis (CHC) represents a chronic opportunistic candida infection. We clarified the presence, localization and participation of α‐defensin‐1 in host response against chronic candidal stimulus.Methods: Immunohistochemically stained CHC biopsies (n = 10) were compared to candida negative idiopathic leukoplakia (n ...
Ali, Ahmed +5 more
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Discovery of α-defensins in basal mammals
Developmental & Comparative Immunology, 2007Alpha-defensins are essential molecules of the innate immune system that have broad spectrum antimicrobial activity against a range of bacteria and viruses. To date, alpha-defensins have only been identified in the Euarchontoglires branch of the mammals.
David J, Lynn, Daniel G, Bradley
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Expression and Purification of Recombinant α-Defensins and α-Defensin Precursors in Escherichia coli
2009Recombinant expression of alpha-defensins can be obtained at efficient levels in Escherichia coli. Amplified alpha-defensin or pro-alpha-defensin coding cDNA sequences are cloned directionally between EcoRI and SalI sites of the pET-28a expression vector and expressed in E. coli BL21 RIS cells. Cells growing exponentially in nutrient-rich liquid medium
Sharel, Figueredo +3 more
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α-Defensins in the gastrointestinal tract
Molecular Immunology, 2003The human intestinal tract is constantly exposed to an enormous indigenous bacterial flora. It has recently been recognised that antimicrobial peptides of the defensin family likely play a role in protection against microbial invasion at a variety of mucosal epithelial surfaces, including that of the intestinal tract.
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Human α Defensin in HIV-Exposed But Uninfected Individuals
JAIDS Journal of Acquired Immune Deficiency Syndromes, 2004Human alpha defensins 1, 2, and 3 are produced by CD8 T cells of HIV-infected long-term nonprogressors and have an antiviral activity. alpha Defensins were examined in peripheral blood mononuclear cells (PBMCs), cervical-vaginal mononuclear cells (CVMCs), and cervical biopsies of 9 HIV-1-exposed but uninfected women (ESNs), 10 HIV-infected patients ...
D. Trabattoni +11 more
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Current protein & peptide science, 2005
The first cyclic peptide discovered in animals is an antimicrobial octadecapeptide that is expressed in leukocytes of rhesus monkeys. The peptide, termed rhesus Theta-defensin 1 (RTD-1) is the prototype of a new family of antimicrobial peptides, which like the previously characterized alpha- and beta-defensin families, possesses broad spectrum ...
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The first cyclic peptide discovered in animals is an antimicrobial octadecapeptide that is expressed in leukocytes of rhesus monkeys. The peptide, termed rhesus Theta-defensin 1 (RTD-1) is the prototype of a new family of antimicrobial peptides, which like the previously characterized alpha- and beta-defensin families, possesses broad spectrum ...
openaire +2 more sources
α-Defensin: Link between inflammation and atherosclerosis
Atherosclerosis, 2007Several markers of inflammation predict the risk of thrombotic cardiovascular events in patients with atherosclerosis. However, the mechanism by which vascular inflammation promotes atherothrombotic disease is incompletely understood. Human neutrophil peptides 1-3, also known as alpha-defensins, are found in human atherosclerotic arteries, inhibit LDL ...
Hisham, Nassar +7 more
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