Results 11 to 20 of about 909,137 (164)

Alpha-defensin binding expands human adenovirus tropism. [PDF]

PLoS Pathogens
Mammalian α-defensins are a family of abundant effector peptides of the mucosal innate immune system. Although primarily considered to be antimicrobial, α-defensins can increase rather than block infection by certain prominent bacterial and viral ...
Cheng Zhao, Jessica M Porter, Phillip C Burke, Niklas Arnberg, Jason G Smith   +4 more
doaj   +6 more sources

Human platelets and megakaryocytes express defensin alpha 1

Platelets, 2020
Platelets are anucleate cells that have a role in several innate immune functions, including the secretion of proteins with antimicrobial activity.
Xareni Valle-Jiménez, Adriana Ramírez-Cosmes, Alba Soledad Aquino-Domínguez, Francisco Sánchez-Peña, José Bustos-Arriaga, María De Los Ángeles Romero-Tlalolini, Honorio Torres-Aguilar, Jeanet Serafín-López, Sergio Roberto Aguilar Ruíz   +8 more
doaj   +4 more sources

Alpha-defensin-dependent enhancement of enteric viral infection. [PDF]

PLoS Pathogens, 2017
The small intestinal epithelium produces numerous antimicrobial peptides and proteins, including abundant enteric α-defensins. Although they most commonly function as potent antivirals in cell culture, enteric α-defensins have also been shown to enhance ...
Sarah S Wilson, Beth A Bromme, Mayumi K Holly, Mayim E Wiens, Anshu P Gounder, Youngmee Sul, Jason G Smith   +6 more
doaj   +4 more sources

Alpha defensin immunoassay is more effective for ruling out rather than diagnosing periprosthetic joint infection (PJI): a prospective cohort study [PDF]

Arthroplasty
Background Accurate and timely diagnosis of periprosthetic joint infection (PJI) is of utmost importance. Although synovial alpha-defensin has shown potential as a biomarker, recent studies have questioned its additional benefit over traditional synovial
Mohammad Kamal Abdelnasser, Ayat Bakhet, Amal Hosni, Dalia Tarik Kamal, Osama Bakr Osman, Mohammed Anter Abdelhameed, Mohamed MA Moustafa   +6 more
doaj   +2 more sources

Contribution of alpha- and beta-defensins to lung function decline and infection in smokers: an association study [PDF]

Respiratory Research, 2006
Background Alpha-defensins, which are major constituents of neutrophil azurophilic granules, and beta-defensins, which are expressed in airway epithelial cells, could contribute to the pathogenesis of chronic obstructive pulmonary disease by amplifying ...
Anthonisen Nicholas R, Connett John E, Ruan Jian, Burkett Kelly M, He Jian-Qing, Wallace Alison M, Paré Peter D, Sandford Andrew J   +7 more
doaj   +3 more sources

Characterization of metabolic alterations in the lean metabolically unhealthy alpha defensin transgenic mice [PDF]

iScience
Summary: Inflammation is consistently linked to dysmetabolism. In transgenic mice (Def+/+) model the neutrophilic peptide, alpha defensin, proved atherogenic. This phenotype occurred despite favorable cholesterol and glucose levels, and lower body weight
Abd Al-Roof Higazi, Emad Maraga, Saja Baraghithy, Shiran Udi, Shahar Azar, Ann Saada, Benjamin Glaser, Dana Avrahami, Suhair Abdeen, Zenab Hamdan, Joseph Tam, Rami Abu Fanne   +11 more
doaj   +2 more sources

Mechanisms of AAV neutralization by human alpha-defensins.

PLoS Pathogens
Antiviral immunity compromises the efficacy of adeno-associated virus (AAV) vectors used for gene therapy. This is well understood for the adaptive immune response.
Jessica M Porter, Kaitlin R Hulce, Mackenzi S Oswald, Kevin Busuttil, Shanan N Emmanuel, Antonette Bennett, Robert McKenna, Jason G Smith   +7 more
doaj   +4 more sources

Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome [PDF]

BMC Genomics, 2009
Background Host defense peptides are a critical component of the innate immune system. Human alpha- and beta-defensin genes are subject to copy number variation (CNV) and historically the organization of mouse alpha-defensin genes has been poorly defined.
Dougan Gordon, Gilbert James GR, Brown Kelly L, Rehaume Linda M, Amid Clara, Hancock Robert EW, Harrow Jennifer L   +6 more
doaj   +2 more sources

Defensin-driven viral evolution.

PLoS Pathogens, 2020
Enteric alpha-defensins are potent effectors of innate immunity that are abundantly expressed in the small intestine. Certain enteric bacteria and viruses are resistant to defensins and even appropriate them to enhance infection despite neutralization of
Karina Diaz, Ciara T Hu, Youngmee Sul, Beth A Bromme, Nicolle D Myers, Ksenia V Skorohodova, Anshu P Gounder, Jason G Smith   +7 more
doaj   +2 more sources

A comparative study of intraoperative frozen section and alpha defensin lateral flow test in the diagnosis of periprosthetic joint infection [PDF]

Acta Orthopaedica, 2019
Background and purpose — For decision-making (aseptic vs. septic), surgeons rely on intraoperatively available tests when a periprosthetic joint infection (PJI) cannot be confirmed or excluded preoperatively.
Irene K Sigmund, Johannes Holinka, Susanna Lang, Sandra Stenicka, Kevin Staats, Gerhard Hobusch, Bernd Kubista, Reinhard Windhager   +7 more
doaj   +2 more sources