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Antiplatelet Activity of α-Lipoic Acid
Journal of Agricultural and Food Chemistry, 2010Alpha-lipoic acid (ALA) is often used as a dietary supplement to prevent and treat chronic diseases associated with excessive oxidative stress. The aim of this study was to investigate the mechanisms of the antiplatelet activity of ALA. ALA significantly inhibited collagen-induced platelet aggregation, thromboxane B(2) (TXB(2)) formation, Ca(2 ...
Yuan-Shu, Lai +3 more
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Alpha-lipoic acid attenuates lipopolysaccharide-induced kidney injury
Clinical and Experimental Nephrology, 2014Kidney is one of the major target organs in sepsis, while effective prevention of septic acute kidney injury has not yet been established. α-Lipoic acid (LA) has been known to exert beneficial effects against lipopolysaccharide (LPS)-induced damages in various organs such as heart, lung, and liver.
Sang Heon, Suh +10 more
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Alpha-Lipoic Acid May Improve Symptomatic Diabetic Polyneuropathy
The Neurologist, 2007In patients with symptomatic diabetic polyneuropathy, is oral alpha-lipoic acid (ALA) effective in improving neuropathic symptoms compared with placebo?The question was addressed with a structured evidence-based clinical neurologic practice review via videoconferencing between 3 academic institutions.
Junger, Tang +4 more
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Alpha-Lipoic Acid Reduces Ethanol Self-Administration in Rats
Alcoholism: Clinical and Experimental Research, 2013The main system of central ethanol (EtOH) oxidation is mediated by the enzyme catalase. By reacting with H2 O2 , brain catalase forms compound I (the catalase-H2 O2 system), which is able to oxidize EtOH to acetaldehyde (ACD) in the brain. We have previously shown that ACD regulates EtOH motivational properties and possesses reinforcing effects by ...
PEANA, Alessandra Tiziana +3 more
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Biochemistry and molecular biology international, 1997
Due to its strained five-membered ring, alpha-lipoic acid (LA) has an absorption band around 330 nm, which is used to quantify its concentration. In order to obtain information for the homolytic rupture of the S-S bond and the formation of dihydrolipoic acid (DHLA), the photochemical reaction of lipoic acid was examined in the presence or absence of ...
S, Matsugo +3 more
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Due to its strained five-membered ring, alpha-lipoic acid (LA) has an absorption band around 330 nm, which is used to quantify its concentration. In order to obtain information for the homolytic rupture of the S-S bond and the formation of dihydrolipoic acid (DHLA), the photochemical reaction of lipoic acid was examined in the presence or absence of ...
S, Matsugo +3 more
openaire +1 more source
Alpha lipoic acid: a novel treatment for depression
Medical Hypotheses, 2000Insulin resistance has been associated with people diagnosed with depression. Conversely, it has also been documented that diabetics have an increased risk of depression. Evidence suggests that insulin activity plays a role in serotonergic activity by increasing the influx of tryptophan into the brain. This increased influx of tryptophan has been shown
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Alpha Lipoic Acid for Schizophrenia
Journal of Clinical Psychopharmacology, 2023Taro Kishi +6 more
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Oxidation of .alpha.-lipoic acid
The Journal of Organic Chemistry, 1975F E, Stary, S J, Jindal, R W, Murray
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Alpha-lipoic acid supplementation and diabetes.
Nutrition reviews, 2009Diabetes is a common metabolic disorder that is usually accompanied by increased production of reactive oxygen species or by impaired antioxidant defenses. Importantly, oxidative stress is particularly relevant to the risk of cardiovascular disease.
Uma, Singh, Ishwarlal, Jialal
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