Results 151 to 160 of about 27,057 (295)
Journal of Diabetes, Volume 18, Issue 5, May 2026.Diabetic neuropathy prevalence declined from 23.4% to 21.5% between 2012 and 2017. About half received treatment, mainly α‐lipoic acid monotherapy; patients were older with comorbidities, leading to more hospitalizations. ABSTRACT Background Diabetic neuropathy (DN) is the most common chronic complication of Type 2 diabetes mellitus (T2DM), with ...
Su Jin Jeong +2 more
wiley +1 more source
Emerging drugs for sickle cell anemia. [PDF]
, 2015 INTRODUCTION: The search for effective therapeutic interventions for sickle cell disease (SCD) has been an ongoing endeavor for over 50 years. During this period, only hydroxyurea (HU), which received US FDA approval in February 1998, was identified as ...
Ballas, Samir K., Singh, Priya C
core +1 more source
OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension
Cell Proliferation, Volume 59, Issue 5, May 2026.This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang +12 more
wiley +1 more source
Antioxidants and Regulation of Antioxidant Enzymes by Cellular Redox Status [PDF]
, 2010 It has been well known that free radicals have numerous detrimental effects in both in vitro and in vivo in biological systems because of their unavoidable and tremendous reactivity against biological macromolecules especially proteins, carbohydrates and
Sadi, Gökhan, Sadi, Özlem
core
The influence of alpha-lipoic acid on ovarian follicle growth in induced aging mice [PDF]
, 2023 Isam B. Sharum +2 more
openalex +1 more source
Journal of Cosmetic Dermatology, Volume 25, Issue 5, May 2026.ABSTRACT Objectives To assess the effectiveness and tolerability of a serum comprised of plant‐based adaptogens (MYS‐REV) for visible improvements in skin changes caused by hormonal fluctuations associated with perimenopause and postmenopause in women. Study Designs A 16‐week open‐label multicenter study evaluated the efficacy and tolerability of twice‐
Zoe D. Draelos +2 more
wiley +1 more source
Mitigative Effects of Alpha-lipoic Acid on the Toxicity of Dimethoate in Male Rats
, 2019 Hani M Abdelsalam
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Skin Glycomics: Unmasking the Role of Glycation End Products in Cutaneous Aging and Dermatology
Journal of Cosmetic Dermatology, Volume 25, Issue 5, May 2026.ABSTRACT Background Skin aging is a multifactorial process influenced by intrinsic and extrinsic factors. Beyond photoaging and oxidative stress, glycation and advanced glycation end products (AGEs) are increasingly recognized as key drivers of cutaneous senescence.
Diala Haykal
wiley +1 more source
Identification and Validation of DLD as a Cuproptosis‐Associated Biomarker in Preeclampsia
The FASEB Journal, Volume 40, Issue 8, 30 April 2026.DLD is identified as a preeclampsia‐associated cuproptosis hub gene by bioinformatics. DLD overexpression inhibits trophoblast proliferation, invasion, and migration, disrupts TCA cycle metabolism, and alters mitochondrial ultrastructure. These findings reveal that DLD may contribute to preeclampsia pathogenesis through cuproptosis.
Shuisen Zheng +4 more
wiley +1 more source