Results 11 to 20 of about 27,826 (225)
Neurobiology of Disease, 2004 Clinical trials report that Ginkgo biloba extracts (e.g., EGb761) reduce cognitive symptoms in age-associated memory impairment and dementia, including Alzheimer disease (AD).
Francesca Colciaghi +8 more
doaj +6 more sources
Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer's Disease Treatment. [PDF]
Pharmaceuticals (Basel), 2018 ADAM (a disintegrin and metalloproteinase) is a family of widely expressed, transmembrane and secreted proteins of approximately 750 amino acids in length with functions in cell adhesion and proteolytic processing of the ectodomains of diverse cell-surface receptors and signaling molecules.
Peron R +4 more
europepmc +5 more sources
Presenilin/γ-secretase and α-secretase-like peptidases cleave human MHC Class I proteins [PDF]
Biochemical Journal, 2006 HLA (human leucocyte antigen)-A2 is an MHC Class I protein with primary functions in T-cell development and initi-ation of immune cell responses. MHC I proteins also play roles in intercellular adhesion, apoptosis, cell proliferation and neuronal plasticity.
Bryce W, Carey +2 more
openaire +2 more sources
The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease [PDF]
, 2015 Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main
Baillie, George S. +3 more
core +1 more source
Cleavage of p75 Neurotrophin Receptor by α-Secretase and γ-Secretase Requires Specific Receptor Domains [PDF]
Journal of Biological Chemistry, 2005 The p75 neurotrophin receptor (p75(NTR)), a member of the tumor necrosis factor superfamily of receptors, undergoes multiple proteolytic cleavage events. These events are initiated by an alpha-secretase-mediated release of the extracellular domain followed by a gamma-secretase-mediated intramembrane cleavage.
Niccolò, Zampieri +3 more
openaire +2 more sources
PLoS ONE, 2022 BackgroundAlzheimer's disease is the most common cause of dementia in the elderly population. It is characterized by the accumulation of amyloid β and intraneuronal neurofibrillary tangles in the brain.
Shatw Khalid Ali, Rojgar H Ali
doaj +1 more source
The role of the Amyloid Precursor Protein mutations and PERK-dependent signaling pathways in the pathogenesis of Alzheimer’s disease [PDF]
, 2016 Alzheimer’s disease (AD) is a highly complex, progressive, age-related neurodegenerative human disease entity. The genetic basis of AD is strictly connected with occurrence of mutations in Amyloid Precursor (APP) gene on chromosome 21.
Diehl, J. Alan +5 more
core +2 more sources
Neurobiology of Disease, 2005 In Alzheimer's disease, the complex catabolism of amyloid precursor protein (APP) leads to the production of amyloid-beta (Abeta) peptide, the major component of amyloid deposits.
Valérie Vingtdeux +12 more
doaj +1 more source
BACE1 activity impairs neuronal glucose oxidation:rescue by beta-hydroxybutyrate and lipoic acid [PDF]
, 2015 Glucose hypometabolism and impaired mitochondrial function in neurons have been suggested to play early and perhaps causative roles in Alzheimer's disease (AD) pathogenesis. Activity of the aspartic acid protease, beta-site amyloid precursor protein (APP)
Arsenian +108 more
core +6 more sources
Alpha beta-and gamma-secretases in alzheimer s disease
Frontiers in Bioscience, 2012 Generation of Amyloid peptide (Abeta) is at the beginning of a cascade that leads to Alzheimer's disease. Currenty, the mechanisms of Abeta generation and Abeta prevention are subject of intensive research. Amyloid precursor protein (APP), as well as beta- and gamma-secretases are the principal players involved in Abeta production, while alpha ...
R. Epis +3 more
openaire +3 more sources