Beta secretase activity in peripheral nerve regeneration [PDF]
Neural Regeneration Research, 2017 While the peripheral nervous system has the capacity to regenerate following a nerve injury, it is often at a slow rate and results in unsatisfactory recovery, leaving patients with reduced function.
Carolyn Tallon, Mohamed H Farah
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Adenosine triphosphate binding cassette subfamily C member 1 (ABCC1) overexpression reduces APP processing and increases alpha- versus beta-secretase activity, in vitro [PDF]
Biology Open, 2021 The organic anion transporter Adenosine triphosphate binding cassette subfamily C member 1 (ABCC1), also known as MRP1, has been demonstrated in murine models of Alzheimer's disease (AD) to export amyloid beta (Abeta) from the endothelial cells of the ...
Wayne M. Jepsen +7 more
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Beta-Secretase 1 Underlies Reactive Astrocytes and Endothelial Disruption in Neurodegeneration. [PDF]
Front Cell Neurosci, 2021 Dysfunction in the neurovascular unit (NVU) is a key component in the progressive deterioration of Alzheimer’s disease (AD) and is critical in vascular dementia. Recent studies have shown that inflammation plays early and perhaps causal roles in the pathogenesis of AD related to NVU damage, possibly in part by overactivating the aspartic acid protease ...
Chacón-Quintero MV +4 more
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Repression of Alzheimer's beta-secretase. [PDF]
Aging (Albany NY), 2013 Alzheimer's disease (AD) is one of the most devastating neuro-degenerative disorders characterized by the two pathological hallmarks of amyloid plaques and neurofibrillary tangles. Multiple environmental factors, such as diet and life style, along with genetic factors are all significant contributors.
Liao FF, Wang R, Park EA.
europepmc +3 more sources
Results of Beta Secretase-Inhibitor Clinical Trials Support Amyloid Precursor Protein-Independent Generation of Beta Amyloid in Sporadic Alzheimer’s Disease [PDF]
Medical Sciences, 2018 The present review analyzes the results of recent clinical trials of β secretase inhibition in sporadic Alzheimer’s disease (SAD), considers the striking dichotomy between successes in tests of β-site Amyloid Precursor Protein-Cleaving ...
Vladimir Volloch, Sophia Rits
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Increased Serum Beta-Secretase 1 Activity is an Early Marker of Alzheimer's Disease. [PDF]
J Alzheimers Dis, 2022 Background: Beta-site APP cleaving enzyme 1 (BACE1) is the rate-limiting enzyme in amyloid-β (Aβ) plaques formation. BACE1 activity is increased in brains of patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI) and plasma levels of BACE1 appears to reflect those in the brains.
Nicsanu R +14 more
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The Alzheimer's disease β-secretase enzyme, BACE1 [PDF]
Molecular Neurodegeneration, 2007 The pathogenesis of Alzheimer's disease is highly complex. While several pathologies characterize this disease, amyloid plaques, composed of the β-amyloid peptide are hallmark neuropathological lesions in Alzheimer's disease brain.
Sarah L Cole, Robert Vassar
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BACE1, the Alzheimer’s beta-secretase enzyme, in health and disease [PDF]
Molecular Neurodegeneration, 2012 The beta-amyloid (Abeta) peptide is the major constituent of amyloid plaques in Alzheimer’s disease (AD) brain and is likely to play a central role in the pathogenesis of this devastating neurodegenerative disorder. The beta-secretase, beta-site amyloid precursor protein cleaving enzyme 1 (BACE1; also called Asp2, memapsin 2), is the enzyme responsible
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The beta secretase BACE1 regulates the expression of insulin receptor in the liver [PDF]
Nature Communications, 2018 A soluble form of insulin receptor in human plasma has been previously reported. Here the authors demonstrate that insulin receptor is cleaved by BACE1 that can regulate biological active insulin receptor levels in a glucose concentration-dependent ...
Paul J. Meakin +11 more
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The therapeutic potential of beta-carotene against neuroinflammation and amyloid beta in SH-SY5Y cells [PDF]
Scientific ReportsNeurodegenerative diseases, particularly Alzheimer’s disease (AD), represent a significant public health challenge due to their increasing prevalence and the lack of effective treatments.
Muhammad Imran Khan +5 more
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