Results 21 to 30 of about 27,905 (224)

The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease [PDF]

, 2015
Alzheimer's disease (AD) is the most common form of dementia in the elderly and its prevalence is set to increase rapidly in coming decades. However, there are as yet no available drugs that can halt or even stabilize disease progression. One of the main
Baillie, George S., Cameron, Ryan T., Hillert, Ellin-Kristina, MacLeod, Ruth   +3 more
core   +1 more source

The role of the Amyloid Precursor Protein mutations and PERK-dependent signaling pathways in the pathogenesis of Alzheimer’s disease [PDF]

, 2016
Alzheimer’s disease (AD) is a highly complex, progressive, age-related neurodegenerative human disease entity. The genetic basis of AD is strictly connected with occurrence of mutations in Amyloid Precursor (APP) gene on chromosome 21.
Diehl, J. Alan, Lewko, Dawid, Majsterek, Ireneusz, Nowak, Alicja, Pytel, Dariusz, Rozpędek, Wioletta   +5 more
core   +2 more sources

Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism

Neurobiology of Disease, 2005
In Alzheimer's disease, the complex catabolism of amyloid precursor protein (APP) leads to the production of amyloid-beta (Abeta) peptide, the major component of amyloid deposits.
Valérie Vingtdeux, Malika Hamdane, Marie Gompel, Séverine Bégard, Hervé Drobecq, Antoine Ghestem, Marie-Eve Grosjean, Vesna Kostanjevecki, Pierre Grognet, Eugeen Vanmechelen, Luc Buée, André Delacourte, Nicolas Sergeant   +12 more
doaj   +1 more source

Knock-in of Human BACE1 Cleaves Murine APP and Reiterates Alzheimer-like PhenoTypes [PDF]

, 2014
Footnotes We thank Roemex and the College for Life Science and Medicine at the University of Aberdeen for their generous support.
Crouch, Barry, Koss, David, Platt, Bettina, Plucinska, Kaja, Riedel, Gernot, Robinson, Lianne   +5 more
core   +1 more source

Presenilin/γ-secretase and inflammation

Frontiers in Aging Neuroscience, 2010
Presenilins (PS) are the catalytic components of γ-secretase, an aspartyl protease that regulates through proteolytic processing the function of multiple signaling proteins.
Carlos A Saura
doaj   +1 more source

Mechanisms of amyloid-β34 generation indicate a pivotal role for BACE1 in amyloid homeostasis

Scientific Reports, 2023
The beta‑site amyloid precursor protein (APP) cleaving enzyme (BACE1) was discovered due to its “amyloidogenic” activity which contributes to the production of amyloid-beta (Aβ) peptides. However, BACE1 also possesses an “amyloidolytic” activity, whereby
Irem Ulku, Filip Liebsch, S. Can Akerman, Jana F. Schulz, Luka Kulic, Christoph Hock, Claus Pietrzik, Alessandro Di Spiezio, Gopal Thinakaran, Paul Saftig, Gerhard Multhaup   +10 more
doaj   +1 more source

Contrasting effects of acute and long-term corticosterone treatment on amyloid-β, beta-secretase 1 expression, and nuclear factor kappa B nuclear translocation

Journal of Integrative Neuroscience, 2019
Regulation of neuroinflammation is critical to control the detrimental impact of chronic stress in the central nervous system. Neuroinflammation occurs in response to chronic stress, leading to enhanced neuronal damage in the brain.
Yangyang Hou, Shaolei Luo, Yaping Zhang, Yue Jia, Haoran Li, Chunjie Xiao, Hongkun Bao, Jing Du   +7 more
doaj   +1 more source

Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine release. [PDF]

PLoS ONE, 2010
Presenilin 1 (PS1) and Presenilin 2 (PS2) are the enzymatic component of the γ-secretase complex that cleaves amyloid precursor protein (APP) to release amyloid beta (Aβ) peptide.
Suman Jayadev, Amanda Case, Alison J Eastman, Huy Nguyen, Julia Pollak, Jesse C Wiley, Thomas Möller, Richard S Morrison, Gwenn A Garden   +8 more
doaj   +1 more source

Pro-domain removal in ASP-2 and the cleavage of the amyloid precursor are influenced by pH [PDF]

, 2002
BACKGROUND: One of the signatures of Alzheimer's disease is the accumulation of aggregated amyloid protein, Abeta, in the brain. Abeta arises from cleavage of the Amyloid Precursor protein by beta and gamma secretases, which present attractive candidates
Brian Austen, Chibuu Liu, Christina Sidera   +2 more
core   +2 more sources

Complex Regulation of gamma-Secretase: from Obligatory to Modulatory Subunits

Frontiers in Aging Neuroscience, 2015
gamma-Secretase is a four subunit, 19-pass transmembrane enzyme that cleaves amyloid precursor protein, catalyzing the formation of amyloid beta peptides that form amyloid plaques, which contribute to Alzheimer’s disease pathogenesis.
Natalya eGertsik, Danica eChiu, Yueming eLI   +2 more
doaj   +1 more source