Results 11 to 20 of about 27,905 (224)

Beta-Secretase: Structure, Function, and Evolution [PDF]

CNS & Neurological Disorders - Drug Targets, 2008
The most popular current hypothesis is that Alzheimer's disease (AD) is caused by aggregates of the amyloid peptide (Abeta), which is generated by cleavage of the Abeta protein precursor (APP) by beta-secretase (BACE-1) followed by gamma-secretase. BACE-1 cleavage is limiting for the production of Abeta, making it a particularly good drug target for ...
Chitra, Venugopal, Christina M, Demos, K S Jagannatha, Rao, Miguel A, Pappolla, Kumar, Sambamurti   +4 more
openaire   +2 more sources

BACE1 activity impairs neuronal glucose oxidation:rescue by beta-hydroxybutyrate and lipoic acid [PDF]

, 2015
Glucose hypometabolism and impaired mitochondrial function in neurons have been suggested to play early and perhaps causative roles in Alzheimer's disease (AD) pathogenesis. Activity of the aspartic acid protease, beta-site amyloid precursor protein (APP)
Arsenian, Bateman, Beal, Bielarczyk, Blass, Bogaert, Bosetti, Bouzier-Sore, Bubber, Butterworth, Casley, Casley, Caspersen, Coleman, Costantini, Danial, David L. Hamilton, DeKosky, DeKosky, Devi, Du, Fang, Forero, Fukumoto, Geula, Gibson, Giménez-Cassina, Guglielmotto, Gómez-Isla, Hager, Hamilton, Harada, Henderson, Henderson, Hirai, Holsinger, Huang, Hussain, Itoh, Jack, Jack, Jack, Jha, John A. Findlay, Johnson, Kankotia, Kawaja, Kim, Knopman, Ko, Korolainen, Lei, Li, Lustbader, Magistretti, Manczak, Martiskainen, Masdeu, Mastrogiacoma, Maurer, McKenna, Meakin, Michael L. J. Ashford, Mirshamsi, Mosconi, Mosconi, Mowrer, Mucke, Mullen, Nelson, Nilsen, Nunomura, O'Connor, Packer, Parker, Patel, Pereira, Perry, Phypers, Puglielli, Reger, Reiman, Sancheti, Shankar, Shearman, Sinha, Small, Sokoloff, Sorbi, Sowell, Swerdlow, Tyler, Vaishnavi, Vassar, Vassar, Velliquette, Vlassenko, von Kienlin, Wilkins, Wischmeyer, Wise, Xun, Yang, Yao, Yao, Zaidan, Zhang, Zhang, Zhao   +108 more
core   +9 more sources

Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements. [PDF]

PLoS Biology, 2008
The presenilin/gamma-secretase complex, an unusual intramembrane aspartyl protease, plays an essential role in cellular signaling and membrane protein turnover.
Matthew L Hemming, Joshua E Elias, Steven P Gygi, Dennis J Selkoe   +3 more
doaj   +1 more source

Gamma-secretase-dependent and -independent effects of presenilin1 on beta-catenin.Tcf-4 transcriptional activity. [PDF]

PLoS ONE, 2008
Presenilin1 (PS1) is a component of the gamma-secretase complex mutated in cases of Familial Alzheimer's disease (FAD). PS1 is synthesized as a 50 kDa peptide subsequently processed to two 29 and 20 kDa subunits that remain associated.
Imma Raurell, Montserrat Codina, David Casagolda, Beatriz Del Valle, Josep Baulida, Antonio García de Herreros, Mireia Duñach   +6 more
doaj   +1 more source

Decreased Deposition of Beta-Amyloid 1-38 and Increased Deposition of Beta-Amyloid 1-42 in Brain Tissue of Presenilin-1 E280A Familial Alzheimer’s Disease Patients

Frontiers in Aging Neuroscience, 2020
Familial Alzheimer’s Disease (FAD) caused by Presenilin-1 (PS1) mutations is characterized by early onset, cognitive impairment, and dementia. Impaired gamma secretase function favors production of longer beta-amyloid species in PS1 FAD.
Felix Dinkel, Diana Trujillo-Rodriguez, Andres Villegas, Johannes Streffer, Marc Mercken, Francisco Lopera, Markus Glatzel, Diego Sepulveda-Falla   +7 more
doaj   +1 more source

Identification of beta-secretase (BACE1) substrates using quantitative proteomics. [PDF]

PLoS ONE, 2009
Beta-site APP cleaving enzyme 1 (BACE1) is a transmembrane aspartyl protease with a lumenal active site that sheds the ectodomains of membrane proteins through juxtamembrane proteolysis.
Matthew L Hemming, Joshua E Elias, Steven P Gygi, Dennis J Selkoe   +3 more
doaj   +1 more source

Synaptic and endosomal localization of active gamma-secretase in rat brain. [PDF]

PLoS ONE, 2010
A key player in the development of Alzheimer's disease (AD) is the gamma-secretase complex consisting of at least four components: presenilin, nicastrin, Aph-1 and Pen-2.
Susanne Frykman, Ji-Yeun Hur, Jenny Frånberg, Mikio Aoki, Bengt Winblad, Jarmila Nahalkova, Homira Behbahani, Lars O Tjernberg   +7 more
doaj   +1 more source

Ectodomain shedding of the amyloid precursor protein: Cellular control mechanisms and novel modifiers [PDF]

, 2006
Proteolytic cleavage in the ectodomain of the amyloid precursor protein (APP) is a key regulatory step in the generation of the Alzheimer's disease amyloid-beta (A beta) pepticle and occurs through two different protease activities termed alpha- and beta-
Lichtenthaler, Stefan F.
core   +1 more source

Cholinesterase inhibitors influence APP metabolism in Alzheimer disease patients

Neurobiology of Disease, 2005
Platelets mirror pathogenic alterations in the central nervous system of Alzheimer disease (AD) patients: an alteration of the Amyloid Precursor Protein (APP) forms pattern and decreased alpha-secretase activity – the non-amyloidogenic APP processing ...
Martina Zimmermann, Barbara Borroni, Flaminio Cattabeni, Alessandro Padovani, Monica Di Luca   +4 more
doaj   +1 more source

Turning the tide on Alzheimer’s disease: modulation of γ-secretase

Cell & Bioscience, 2022
Alzheimer’s disease (AD) is the most common type of neurodegenerative disorder. Amyloid-beta (Aβ) plaques are integral to the “amyloid hypothesis,” which states that the accumulation of Aβ peptides triggers a cascade of pathological events leading to ...
Joanna E. Luo, Yue-Ming Li
doaj   +1 more source