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Nitrogen recycling by the gut microbiome in sarcopenia [PDF]
Frontiers in MicrobiologyIntroductionSarcopenia, which is defined as loss of skeletal muscle mass and strength, affects up to 70% of patients with liver cirrhosis. Since hibernating animals maintain muscle mass through microbial nitrogen recycling, urease-producing bacteria may ...
Rosa Haller +14 more
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Genetic epilepsy with febrile seizures plus – an overview [PDF]
Romanian Journal of Neurology, 2021 Genetic epilepsy with febrile seizures plus (GEFS+) is characterized by a group of genetic epilepsies associated predominately with an autosomal dominant pattern, but also with de novo and autosomal-recessive inheritance, these last two found in a small ...
Madalina Radu +3 more
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Inherited/Genetically-Associated Pheochromocytoma/ Paraganglioma Syndromes and COVID-19
Medicina, 2021 In some subjects with inherited pheochromocytoma/paraganglioma (PPG) syndromes, hypoxia-inducible factor 1 alpha (HIF1α) stabilization/activation could lead to an increase in angiotensin converting enzymes (ACE).
Ioannis Ilias +3 more
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PLoS ONE, 2021 BackgroundThe IgE-mediated activation of mast cells and basophils results in the secretion of many substances, including the release of FceRI-alpha subunit.
Donald MacGlashan
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A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization. [PDF]
PLoS ONE, 2016 The heteromeric membrane protein Organic Solute Transporter alpha/beta is the major bile acid efflux transporter in the intestine. Physical association of its alpha and beta subunits is essential for their polarized basolateral membrane localization and ...
Shuhua Xu +6 more
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Transcriptional regulation of PP2A-A alpha is mediated by multiple factors including AP-2alpha, CREB, ETS-1, and SP-1. [PDF]
PLoS ONE, 2009 Protein phosphatases-2A (PP-2A) is a major serine/threonine phosphatase and accounts for more than 50% serine/threonine phosphatase activity in eukaryotes.
He-Ge Chen +11 more
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Transcriptome sequencing identifies genes associated with invasion of ovarian cancer
Journal of International Medical Research, 2020 Objective To identify key genes in ovarian cancer using transcriptome sequencing in two cell lines: MCV152 (benign ovarian epithelial tumour) and SKOV-3 (ovarian serous carcinoma).
Xiandong Peng, Min Yu, Jiazhou Chen
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Scientific Reports, 2021 Pseudomonas aeruginosa DN1 can efficiently utilize fluoranthene as its sole carbon source, and the initial reaction in the biodegradation process is catalyzed by a ring-hydroxylating dioxygenase (RHD).
Shu-Wen Xue +4 more
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Brazilian Journal of Infectious Diseases, 2021 Since the first described human infection with SARS-CoV-2 in December of 2019 many subunit protein vaccines have been proposed for use in humans. Subunit vaccines use one or more antigens suitable for eliciting a robust immune response.
Mehrdad Mohammadi +2 more
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G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits. [PDF]
Proceedings of the National Academy of Sciences, 1991 Heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) are central to the signaling processes of multicellular organisms. We have explored the diversity of the G protein subunits in mammals and found evidence for a large family of genes that encode the alpha subunits.
M P, Strathmann, M I, Simon
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