A point mutation of integrin beta 1 subunit blocks binding of alpha 5 beta 1 to fibronectin and invasin but not recruitment to adhesion plaques. [PDF]
, 1992 A point mutation in a highly conserved region of the beta 1 subunit, Asp130 to Ala (D130A) substitution, abrogates the Arg-Gly-Asp (RGD)-dependent binding of alpha 5 beta 1 to fibronectin (FN) without disrupting gross structure or heterodimer assembly ...
Ginsberg, MH +4 more
core +2 more sources
Analysis of Maxi-K alpha subunit splice variants in human myometrium
Reproductive Biology and Endocrinology, 2004 Background Large-conductance, calcium-activated potassium (Maxi-K) channels are implicated in the modulation of human uterine contractions and myometrial Ca2+ homeostasis.
Morrison John J +2 more
doaj +1 more source
Phycocyanin alpha-subunit phycocyanobilin lyase. [PDF]
Proceedings of the National Academy of Sciences, 1992 Phycobiliproteins, unlike other light-harvesting proteins involved in photosynthesis, bear covalently attached chromophores. The bilin chromophores are attached through thioether bonds to cysteine residues. The cyanobacterium Synechococcus sp. PCC 7002 has eight distinct bilin attachment sites on seven polypeptides, all of which carry the same ...
C D, Fairchild +5 more
openaire +2 more sources
KCNE regulation of K+ channel trafficking – a Sisyphean task?
Frontiers in Physiology, 2012 Voltage-gated potassium (Kv) channels shape the action potentials of excitable cells and regulate membrane potential and ion homeostasis in excitable and nonexcitable cells.
Vikram Anmol Kanda +2 more
doaj +1 more source
Phylogenomic analyses reveal the evolutionary origin of the inhibin alpha-subunit, a unique TGFbeta superfamily antagonist. [PDF]
PLoS ONE, 2010 Transforming growth factor-beta (TGFbeta) homologues form a diverse superfamily that arose early in animal evolution and control cellular function through membrane-spanning, conserved serine-threonine kinases (RII and RI receptors).
Jie Zhu +10 more
doaj +1 more source
Nitrile hydratase genes are present in multiple eukaryotic supergroups. [PDF]
PLoS ONE, 2012 Nitrile hydratases are enzymes involved in the conversion of nitrile-containing compounds into ammonia and organic acids. Although they are widespread in prokaryotes, nitrile hydratases have only been reported in two eukaryotes: the choanoflagellate ...
Alan O Marron +2 more
doaj +1 more source
Molecular dissection of I(A) in cortical pyramidal neurons reveals three distinct components encoded by Kv4.2, Kv4.3, and Kv1.4 alpha-subunits [PDF]
, 2010 The rapidly activating and inactivating voltage-gated K(+) (Kv) current, I(A), is broadly expressed in neurons and is a key regulator of action potential repolarization, repetitive firing, backpropagation (into dendrites) of action potentials, and ...
Nerbonne, Jeanne M, Norris, Aaron J
core +2 more sources
Characterisation of the tryptophan synthase alpha subunit in maize
BMC Plant Biology, 2008 Background In bacteria, such as Salmonella typhimurium, tryptophan is synthesized from indole-3-glycerole phosphate (IGP) by a tryptophan synthase αββα heterotetramer.
Gierl Alfons +6 more
doaj +1 more source
MedicinaBackground and Objectives: Cardiovascular disease remains a leading cause of mortality in Diabetes mellitus (DM), where chronic hyperglycemia induces oxidative stress, mitochondrial dysfunction, and hypoxia in cardiomyocytes.
Sinem Durmus +7 more
doaj +1 more source
Insects, 2023 The Na+/K+ ATPase (NKA) is present in the cellular membrane of most eukaryotic cells. It utilizes energy released by ATP hydrolysis to pump sodium ions out of the cell and potassium ions into the cell, which establishes and controls ion gradients ...
Nathan P. Martinez +3 more
doaj +1 more source