Results 31 to 40 of about 566,712 (212)

Serum Levels of MicroRNA-210 as a Pathogenic Factor in Patients with Diabetes and Diabetic Nephropathy: A Cross-sectional Study

Journal of Clinical and Diagnostic Research
Introduction: Diabetes Mellitus (DM) is a foremost global health challenge, causing disability and premature death. It leads to severe micro and macrovascular complications, including Diabetic Nephropathy (DN), which affects 20% of patients worldwide. Up
Divya Singh, Ivvala Anand Shaker, Ashishkumar Agravatt   +2 more
doaj   +1 more source

Individual knock out of glycine receptor alpha subunits identifies a specific requirement of glra1 for motor function in zebrafish.

PLoS ONE, 2019
Glycine receptors (GlyRs) are ligand-gated chloride channels mediating inhibitory neurotransmission in the brain stem and spinal cord. They function as pentamers composed of alpha and beta subunits for which 5 genes have been identified in human (GLRA1 ...
Eric Samarut, Domitille Chalopin, Raphaëlle Riché, Marc Allard, Meijiang Liao, Pierre Drapeau   +5 more
doaj   +1 more source

GABA-A Alpha 2/3 but Not Alpha 1 Receptor Subunit Ligand Inhibits Harmaline and Pimozide-Induced Tremor in Rats

Biomolecules, 2023
Treatment of tremors, such as in essential tremor (ET) and Parkinson’s disease (PD) is mostly ineffective. Exact tremor pathomechanisms are unknown and relevant animal models are missing.
Barbara Kosmowska, Martyna Paleczna, Dominika Biała, Justyna Kadłuczka, Jadwiga Wardas, Jeffrey M. Witkin, James M. Cook, Dishary Sharmin, Monika Marcinkowska, Katarzyna Z. Kuter   +9 more
doaj   +1 more source

Architecture of coatomer: Molecular characterization of delta-COP and protein interactions within the complex [PDF]

, 1996
Copyright © 2011 by The Rockefeller University Press.Coatomer is a cytosolic protein complex that forms the coat of COP I-coated transport vesicles.
Auerbach, S, Faulstich, D, Harter, C, Lottspeich, F, Orci, L, Ravazzola, M, Stenbeck, G, Tschochner, H, Wegchingel, S, Wieland, FT   +9 more
core   +1 more source

Digoxin attenuates LPS-induced acute lung injury in mice via NF-κB and HIF-1α inhibition

Biomolecules & Biomedicine
Acute lung injury (ALI), which can progress to the highly lethal acute respiratory distress syndrome (ARDS), remains a condition with limited pharmacological interventions, highlighting the urgent need for mechanism-informed repurposing strategies ...
Abdulaziz M. Alzahrani, Mai A. Alim A. Sattar Ahmad, Wafaa S. Ramadan, Huda M. Alkreathy   +3 more
doaj   +1 more source

Evaluation of the Phosphoproteome of Mouse Alpha 4/Beta 2-Containing Nicotinic Acetylcholine Receptors In Vitro and In Vivo

Proteomes, 2018
Activation of nicotinic acetylcholine receptors containing α4 and β2 subunits (α4/β2* nAChRs) in the mammalian brain is necessary for nicotine reinforcement and addiction. We previously identified interactions between α4/β
Megan B. Miller, Rashaun S. Wilson, TuKiet T. Lam, Angus C. Nairn, Marina R. Picciotto   +4 more
doaj   +1 more source

Immunoaffinity purification of GABAA receptor alpha-subunit iso-oligomers. Demonstration of receptor populations containing alpha 1 alpha 2, alpha 1 alpha 3, and alpha 2 alpha 3 subunit pairs.

Journal of Biological Chemistry, 1991
Novel methods for the isolation of gamma-aminobutyric acidA (GABAA) receptor alpha subunit iso-oligomers have been developed. Thus, populations of GABAA receptors containing the GABAA receptor alpha 1 subunit, the alpha 2 subunit, and the alpha 3 subunit have been purified from sodium deoxycholate extracts of bovine cerebral cortex with the retention ...
M J, Duggan, S, Pollard, F A, Stephenson
openaire   +2 more sources

Distinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions. [PDF]

, 1993
Integrin-mediated cell adhesion often results in cell spreading and the formation of focal adhesions. We exploited the capacity of recombinant human alpha IIb beta 3 integrin to endow heterologous cells with the ability to adhere and spread on fibrinogen
Chen, Y, Ginsberg, MH, Loftus, JC, O'Toole, TE, Takada, Y, Ylänne, J   +5 more
core  

Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus [PDF]

, 2005
Persistent activation of GABAA receptors by extracellular GABA (tonic inhibition) plays a critical role in signal processing and network excitability in the brain.
Kullmann, D.M., Scimemi, A., Semyanov, A., Sperk, G., Walker, M.C.   +4 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source